Navigation Links
Improved estrogen reception may sharpen fuzzy memory
Date:7/29/2008

GAINESVILLE, Fla. Estrogen treatments may sharpen mental performance in women with certain medical conditions, but University of Florida researchers suggest that recharging a naturally occurring estrogen receptor in the brain may also clear cognitive cobwebs.

The discovery suggests that drugs can be developed to offset "senior moments" related to low estrogen levels, as well as to protect against neurological diseases, all while avoiding the problems associated with adding estrogen to the body.

Writing online in Molecular Therapy in July, scientists with UF's McKnight Brain Institute describe how they improved thought processes in female mice bred with the inability to produce estrogen receptor-alpha, a protein apparently necessary for healthy learning and memory.

"We were able to restore function in these animals, not by dosing them with estrogen, but by enabling them to use the estrogen that was naturally present in their bodies," said Tom Foster, Ph.D., the Evelyn F. McKnight chair for brain research in memory loss at the UF College of Medicine. "We discovered that you can affect the estrogen receptor directly in the hippocampus, right where it's needed to address memory and spatial learning."

Changes in the estrogen receptor have been associated with age-related memory deficits and an increased incidence of Alzheimer's disease among women. In addition, previous studies have shown estrogen replacement may improve cognition in postmenopausal women and younger women with low estrogen levels. Estrogen also appears to protect against Alzheimer's disease and dementia.

The downside is that estrogen is a powerful hormone that has far-reaching effects throughout the body. It has been associated with a slight increase in women's risk for breast cancer, heart disease in patients with existing cardiovascular problems, and stroke.

"Estrogen may act as a growth agent for cancer, but in the brain, it appears to
'/>"/>

Contact: John Pastor
jdpastor@ufl.edu
352-273-5815
University of Florida
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Mobilizing white blood cells to the lung: New discovery could lead to an improved influenza vaccine
2. UF researchers develop improved gene therapy agent
3. Lean and mean biomass-degrading fungus reveals capabilities for improved biofuel production
4. Brain study may lead to improved epilepsy treatments
5. Chesapeake Bay ecosystem health remains poor, but slightly improved in 2007
6. Improved foam for varicose veins found to be safe in preliminary results from phase II trial
7. Physician-scientist urges improved drug regulation to ensure heart safety of non-heart drugs
8. UCR researchers awarded nearly $1.7M to develop improved cowpea varieties
9. In-vitro fertilization improved with 3-D/4-D-guided embryo transfer and new placement target
10. Improved e-jet printing provides higher resolution and more versatility
11. Estrogen helps drive distinct, aggressive form of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... in German . ... they are a common sight on the roads of the ... the list of new vehicle registrations for the second time. ... where electric vehicles claim only a small portion of the ... Germany, only a mere 8000 are electric powered. The main ...
(Date:7/24/2014)... inside your gut that has gone undetected by scientists ... San Diego State University has found that more than ... described virus, named crAssphage, which infects one of the ... This phylum of bacteria is thought to be connected ... appears today in Nature Communications ., Robert A. ...
(Date:7/23/2014)... Protection Agency (EPA) today announced that environmental health ... Amherst School of Public Health and Health Sciences ... Achieve Results (STAR) grant to measure indoor air ... in subarctic North America to determine possible health ... culturally-relevant recommendations for mitigation. , Peltier, who will ...
Breaking Biology News(10 mins):Nano-supercapacitors for electric cars 2Nano-supercapacitors for electric cars 3Newly discovered gut virus lives in half the world's population 2Newly discovered gut virus lives in half the world's population 3Studying impacts of indoor air pollution on tribal communities 2Studying impacts of indoor air pollution on tribal communities 3
... the logic of inheritance in his monastery garden with no ... House. So why couldn,t Darwin have done it too? A ... influences and research focus gave him a viewpoint that prevented ... even in his own work. Darwin,s commitment to ...
... just off the east coast of Australia, picturesque North ... some of the inhabitants of the island,s creeks and ... territorial creatures, explains ecologist Robbie Wilson of the University ... one another, they size each other up in a ...
... HAVEN, FLFresh strawberries. Just the mention of this iconic ... of shortcake, fruity drinks and sweet desserts. Researchers interested ... that "sensory quality" of strawberries, a strong influence on ... of sweetness, aroma, texture, and appearance. The goals ...
Cached Biology News:Why didn't Darwin discover Mendel's laws? 2Crafty Australian crayfish cheat 2Analysis of fresh strawberries reveals consumer preferences 2
(Date:7/24/2014)... balances – 4 steps – One Recommendation: the web-based ... narrows down the mass of product choices to a ... , First, select the working environment, then enter the ... define the accuracy – it’s really that simple. Specifying ... to models that fit best with the customer’s industry ...
(Date:7/24/2014)... 2014 Draper University, a top ... to announce that for 6 weeks this summer, ... converge on the Draper University campus in the ... program focused on entrepreneurship, building real-world skills, and ... running its sixth cohort, continues to refresh its ...
(Date:7/24/2014)... 2014   Cypher Genomics, Inc., the ... Adam Simpson as president and chief ... comprehensive annotation and interpretation of individual human genomes ... "Cypher,s technology has the potential to play a ... accuracy, optimizing therapeutic approaches and reducing adverse drug ...
(Date:7/24/2014)... Diego, CA (PRWEB) July 24, 2014 ... the reporting of molecular diagnostic test results. It ... capabilities necessary for the validation and reporting of ... oncology. Molecular diagnostics is a rapidly growing area ... infectious disease, genetic predisposition, cancer, and companion diagnostics ...
Breaking Biology Technology:Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 2Summer Entrepreneurship Program Kicked Off by Draper University in Silicon Valley 3Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 2Cypher Genomics Announces the Appointment of Adam Simpson as President and COO to Advance Transformative Genome Interpretation Technology 3New DNA-barcode Patent Virtually Eliminates False Test Results and Sample Mix-up 2
... BRUNSWICK, N.J., Feb. 18 Senesco Technologies, Inc. ... financial results for the three months ended December 31, 2008. ... 2008 was $1,624,341, or $0.09 per share, compared with a ... three month period ended December 31, 2007. This increase ...
... a,biotechnology company focused on novel therapeutic and preventative,approaches ... of an EUR18M ($23M) Series B financing round ... operational and clinical level. Novartis Venture Fund,Fountain Healthcare ... all participated in the funding. , ...
... more light than heat. Engineers working in optical technologies ... with much greater speed than do electrical signals, says ... Bethlehem, Pa. If they are guided with sufficient precision ... can bring about applications in spectroscopy, sensing and medical ...
Cached Biology Technology:Senesco Technologies Reports Second Quarter Fiscal 2009 Financial Results 2Senesco Technologies Reports Second Quarter Fiscal 2009 Financial Results 3Senesco Technologies Reports Second Quarter Fiscal 2009 Financial Results 4Senesco Technologies Reports Second Quarter Fiscal 2009 Financial Results 5Senesco Technologies Reports Second Quarter Fiscal 2009 Financial Results 6Senesco Technologies Reports Second Quarter Fiscal 2009 Financial Results 7Opsona Therapeutics Closes EUR18M Funding 2Opsona Therapeutics Closes EUR18M Funding 3Opsona Therapeutics Closes EUR18M Funding 4Engineers tune a nanoscale grating structure to trap and release a variety of light waves 2Engineers tune a nanoscale grating structure to trap and release a variety of light waves 3
Standard 2" and 3" Fiberboard Boxes can be sold separately or with 16, 25, 36, 49, 64, 81 or 100 cell dividers. Fiberboard boxes can also be ordered with corresponding freezer racks...
Borosilicate Glass. Certified for use with the Beacon 2000 Systems, 1,000 tubes/case...
Whole blood is collected from mice (Swiss Webster, 8-10 weeks old,either sex) and processed within 45 minutes of collection. The complement is then filtered and pooled on ice, bottled and stored at -...
... technology incorporating the sophisticated DirectDrive architecture ... new Varian NMR System is undeniably ... ,The Varian NMR System features parallel ... channel, providing pulse sequence programming power ...
Biology Products: