Navigation Links
Improved characterization of nanoparticle clusters for EHS and biosensors research
Date:10/26/2011

The tendency of nanoparticles to clump together in solution"agglomeration"is of great interest because the size of the clusters plays an important role in the behavior of the materials. Toxicity, the persistence of the nanomaterials in the environment, their efficacy as biosensors and, for that matter, the accuracy of experiments to measure these factors, are all known to be affected by agglomeration and cluster size. Recent work* at the National Institute of Standards and Technology (NIST) offers a way to measure accurately both the distribution of cluster sizes in a sample and the characteristic light absorption for each size. The latter is important for the application of nanoparticles in biosensors.

A good example of the potential application of the work, says NIST biomedical engineer Justin Zook, is in the development of nanoparticle biosensors for ultrasensitive pregnancy tests. Gold nanoparticles can be coated with antibodies to a hormone** produced by an embryo shortly after conception. Multiple gold nanoparticles can bind to each hormone, forming clusters that have a different color from unclustered gold nanoparticles. But only certain size clusters are optimal for this measurement, so knowing how light absorbance changes with cluster size makes it easier to design the biosensors to result in just the right sized clusters.

The NIST team first prepared samples of gold nanoparticlesa nanomaterial widely used in biologyin a standard cell culture solution, using their previously developed technique for creating samples with a controlled distribution of sizes***. The particles are allowed to agglomerate in gradually growing clusters and the clumping process is "turned off" after varying lengths of time by adding a stabilizing agent that prevents further agglomeration.

They then used a technique called analytical ultracentrifugation (AUC) to simultaneously sort the clusters by size and measure their light absorption. The centri
'/>"/>

Contact: Michael E. Newman
michael.newman@nist.gov
301-975-3025
National Institute of Standards and Technology (NIST)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Improved living environments can reduce health problems for women and children
2. Breeding soybeans for improved feed
3. First proof in patients of an improved magic bullet for cancer detection and radio-therapy
4. Improved method for capturing proteins holds promise for biomedical research
5. U of M researchers use improved imaging technique; discover a better approach to diagnosing epilepsy
6. Trastuzumab and chemotherapy improved survival in HER2-postive breast and brain cancer patients
7. New genetic map of potato may lead to improved crops
8. Nanowire-based sensors offer improved detection of volatile organic compounds
9. China needs improved administrative system for nuclear power safety
10. IOF calls for improved strategies to close the treatment gap and reduce future burden of fractures
11. NPL helps Senceive to offer improved monitoring of structural assets across the UK
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Improved characterization of nanoparticle clusters for EHS and biosensors research
(Date:9/30/2014)... on Earth, but when the climate changes and temperatures ... The amount of time needed to adjust to new ... in the future, reveals a new study from researchers ... journal Proceedings of the Royal Society B . ... of greenhouse gases in the atmosphere. The greenhouse effect ...
(Date:9/30/2014)... you want your doctor to know what goes wrong with ... good idea to know what "normal" actually is. That,s where ... of the FASEB Journal comes in. ... transcriptomea key set of molecules that can help scientists "see" ... time. What,s more, they found never-before-detected gene activity and that ...
(Date:9/30/2014)... 2014) People who suffer from asthma may think ... their asthma besides properly taking medications and avoiding allergic ... the Annals of Allergy, Asthma and Immunology , ... Asthma and Immunology (ACAAI), asthma sufferers can learn lessons ... woman described in the Annals article improved her asthma ...
Breaking Biology News(10 mins):Shape up quickly -- applies to fish, too! 2Scientists identify which genes are active in muscles of men and women 2Asthma symptoms kicking up? Check your exposure to air pollution 2
... penguins in Antarctica than was previously thought, according to ... of researchers using high-resolution satellite mapping technology. This first-ever ... important benchmark for monitoring the impact of environmental change ... from the University of Minnesota Polar Geospatial Center co-authored ...
... press release is available in German . , ... beings in their own right. This changed about one billion years ... cells. Since then, they have lost much of their autonomy. As ... into the cell nucleus; today, chloroplasts would no longer be able ...
... Calif.All animals seem to have ways of exchanging informationmonkeys ... and fireflies light up their bellies to attract mates. ... among the most abundant animals on the planet, little ... led by California Institute of Technology (Caltech) biologists has ...
Cached Biology News:Scientists complete first-ever emperor penguin count from space 2Direct transfer of plant genes from chloroplasts into the cell nucleus 2Decoding worm lingo 2Decoding worm lingo 3
(Date:9/30/2014)... Hungary , September 30, 2014 ... and intuitive browsing of chemistry in documents ... chemistry software solutions and consulting services for life ... chemical information and generate Markush structures from documents. ... an organizations intellectual property, however generating and understanding ...
(Date:9/30/2014)... Calif. , Sept. 30, 2014 FemCap ... women,s health announces its receipt of a patent No: ... menstrual cup has also received FDA clearance in the ... and the CE in Europe. This patent is related to ... with this issuance, the company is releasing FemmyCycle Teen, ...
(Date:9/30/2014)... Boston, MA (PRWEB) September 30, 2014 ... communications (UC) and collaboration company is dedicated to ... data connectivity needs. Julie Power, a ... team to ensure collaboration solutions stays connected and ... response to the increased movement of businesses to ...
(Date:9/30/2014)... September 30, 2014 Back in the 1970’s, ... square feet. per employee, which included space for circulation and ... says Jeff Howell, partner at Nidea Corporate Real Estate ... Toronto. “By the year 2000, however, 250 square feet ... that number come down to 175 to 225 square feet, ...
Breaking Biology Technology:ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2The FemmyCycle 2SoundConnect Expands Carrier Services Division 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3
... Olive Branch Fund: A Thisbe and Noah Scott Legacy, ... today announced its first funding award to Kevin Eggan, ... at Harvard University.  The award will support Dr. Eggan,s ... that affect it.  Dr. Eggan is a leading researcher ...
... PRINCETON, N.J., June 29, 2011 PharmaNet Development Group, Inc. ... its cash tender offer and consent solicitation (the "Offer") for ... Notes due 2017 (the "Notes"), it has elected to extend ... York City time, on July 6, 2011, unless extended or ...
... Associates® - San Francisco, a specialized executive search firm ... arena, welcomes Eduard Alberts, Ph.D. as Vice President and ... of experience and success in the life sciences industry, ... companies and a wide array of cultures. His prior ...
Cached Biology Technology:The Olive Branch Fund Announces Funding Award to Harvard Researcher 2PharmaNet Extends Expiration Time in its Tender Offer and Consent Solicitation 2PharmaNet Extends Expiration Time in its Tender Offer and Consent Solicitation 3Eduard Alberts, Ph.D. Joins Sanford Rose Associates - San Francisco 2
Anti-Dynamin Monoclonal Antibody Description: 100 g Research Focus: neuroscience Storage: -20C Shipping Temperature: 4C...
Carrier-Free Recombinant Human Flt-3/Flk-2 Ligand (Flt3/Flk2 Ligand, Flt3L, Flt3-L, Flk2L, Flk2-L) 100 ug...
Anti-CD74 Monoclonal Antibody Description: 200 l Research Focus: cell surface antigens Storage: 4C Shipping Temperature: 4C...
POU domain, class 2, transcription factor 2,...
Biology Products: