Navigation Links
Improved Pharma Publishes Review Article in AAPS PharmSciTech
Date:6/11/2019

Improved Pharma LLC announces the publication of “Predictive and Accelerated Formulation Design Using Synchrotron Methods” in the July 2019 issue of AAPS PharmSciTech. The article was published online on April 29th, 2019. The authors are Stephen R. Byrn and Pamela A. Smith of Improved Pharma, along with Xiaoming Sean Chen of Purdue University.

The article is the most recent addition to a theme dedicated to “Team Science and Education for Pharmaceuticals: the NIPTE Model”. NIPTE, or The National Institute for Pharmaceutical Technology & Education, is a collaboration of academia and industry. The mission is to improve the way medicines are designed, developed and manufactured to meet the needs of patients in the 21st century.

Improved Pharma’s review article presents a predictive/accelerated formulation strategy that is ideally suited for poorly soluble solid oral drugs. The first step is to understand and leverage key material properties such as solubility, BCS classification, and the solid-state landscape. Next, amorphous forms and/or complexes are formed, which present a valuable way to ensure high exposure in preclinical studies. To fully characterize important structural information about these complexes, synchrotron-based pair distribution function (PDF) analysis is used. This powerful technique aids in anticipating/predicting stability. Over-reaching all activities is a Quality by Design approach focused on Learning before Doing, which emphasizes doing it right the first time to mitigate risks and reduce time to market.

Commented Improved Pharma’s COO, Dr. Pamela Smith, “It’s an exciting time to be working in this field. Combining synchrotron PDF analysis with formulation design has allowed us to do more than just understand the structure of the complexes. It has given us the ability to predict the relative stability of one formulation over another.”
Adds Improved Pharma’s CSO, Professor Stephen Byrn, “By using these new technologies, we are moving into a new golden age of pharmaceuticals where we can attack many of the most difficult and troublesome diseases.”

The publication is available online at: https://link.springer.com/article/10.1208/s12249-019-1375-2.

About Improved Pharma
Improved Pharma is a research and information company dedicated to improving pharmaceutical methods, formulations, and processes. Dr. Stephen Byrn and Sarah Byrn founded the company in 2006 after the successful acquisition of their first company, SSCI. Dr. Pamela Smith joined the company in 2018 after an 18-year tenure with SSCI. Improved Pharma offers services such as analytical testing, synchrotron-based formulation design, and expert consulting aiding the development and defense of intellectual property matters.

For more information about the techniques discussed in this article or about Improved Pharma’s services, please contact us at 1-765-463-9951 or info(at)improvedpharma(dot)com.

Read the full story at https://www.prweb.com/releases/improved_pharma_publishes_review_article_in_aaps_pharmscitech/prweb16352435.htm.


'/>"/>
Source: PRWeb
Copyright©2019 Vocus, Inc.
All rights reserved


Related biology news :

1. Abcam Collaborates with Visikol to Develop New Tools for Improved Tissue Clearing and 3D Imaging
2. Improved mouse model will accelerate research on potential Ebola vaccines, treatments
3. Improved electricity access has little impact on climate change
4. S-equol supplements associated with improved measures of reproductive health in postmenopausal women
5. Federal food program puts food on the table, but dietary quality could be improved
6. Plant variants point the way to improved biofuel production
7. Samtools CRAMS in support for improved compression formats
8. Developing an improved liposuction technique that melts fat
9. University of Toronto biologists pave the way for improved epilepsy treatments
10. New meta-analysis builds on the power of whey protein for improved body composition
11. Improved access to integrated biodiversity data for science, practice, and policy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/9/2019)... ... ... With a demand in healthcare to lower unneeded emergency room visits and provide ... in the coming years, according to a new report on the industry by market ... is a detailed look at the current state of these healthcare outlets, including the ...
(Date:8/6/2019)... (PRWEB) , ... August 05, 2019 , ... Keck Graduate ... KGI School of Pharmacy and Health Sciences (SPHS). , “Dean Zdanowicz is highly regarded ... of Trustees Chairman Jim Widergren. “He is a great choice to build on the ...
(Date:8/4/2019)... ... , ... Stay on top of current hot topics through free webinars presented ... webinars is free, so be sure to register today to save your place! Participate ... to see our upcoming webinars: , CLINICAL OPERATIONS , August 27 – Friend or ...
Breaking Biology News(10 mins):
(Date:7/2/2019)... ... ... Leading Regenerative Veterinary Medicine company, VetStem Biopharma , was recently featured in ... on regenerative veterinary medicine as a means of improving the quality of life for ... Brentwood and Pacific Palisades International Film Festival in Los Angeles, California where it received ...
(Date:6/12/2019)... ... June 12, 2019 , ... ... testing instruments for the Pharmaceutical, Biotechnology, Medical Device and Food Packaging Industries, is ... signed. The agreement will grant exclusive rights for Zillion to represent LDA in ...
(Date:6/11/2019)... and ROANOKE, Va. (PRWEB) , ... June 11, ... ... optimized for microlearning engagement, and Carilion Clinic, a national leader in opioid treatment, ... latest in virtual care. , Mytonomy recently deployed its virtual care ...
(Date:5/31/2019)... TORONTO (PRWEB) , ... May 29, 2019 , ... For ... but the toughest forms of cancer demand breakthrough therapies. Advances in immuno-oncology have led ... a patient’s own T cells with engineered T cell receptors known as “CARs”. The ...
Breaking Biology Technology: