Navigation Links
Implanting embryonic cardiac cells prevents arrhythmias
Date:12/5/2007

When researchers at Cornell, the University of Bonn and the University of Pittsburgh transplanted living embryonic heart cells into cardiac tissue of mice that had suffered heart attacks, the mice became resistant to cardiac arrhythmias, thereby avoiding one of the most dangerous and fatal consequences of heart attacks.

The discovery, reported in this week's issue of Nature, has profound implications for using cell-transplant therapies to restore damaged heart tissue.

The researchers, including Michael Kotlikoff, the Austin O. Hooey Dean of Cornell's College of Veterinary Medicine, one of the paper's senior authors, discovered that a protein called connexin43, expressed by the transplanted embryonic heart cells, improved electrical connections to other heart cells. The researchers showed that the improved connections helped activate the transplanted cells deep within the damaged section of the heart tissue. The technique reversed the risk of developing ventricular arrhythmias after a heart attack, the number one cause of sudden death in the Western world.

In the past, scientists have transplanted a variety of cell types into failing hearts with modest improvement of function, although transplanting skeletal muscle cells made things worse and led to more arrhythmias. Surprisingly, when co-author Bernd Fleischmann at the University of Bonn and colleagues transplanted embryonic cardiac cells, the hearts' electrical stability and function returned to normal.

Scientists recognize the untapped potential of using cell-based therapies to counter many debilitating diseases, but they have not had tools to assess the function of the cells once transferred. In Kotlikoff's laboratory, the researchers determined that the transplanted embryonic cells were making electrical connections with normal heart cells. Using genetically modified heart cells that express a fluorescent sensor, they established that transplanted heart cells were activated during norm
'/>"/>

Contact: Sabina Lee
SSL37@cornell.edu
607-255-3024
Cornell University Communications  
Source:Eurekalert

Page: 1 2

Related biology news :

1. Scientists identify embryonic stem cells by appearance alone
2. Embryonic stem cell strategy advanced with UCSF finding
3. Human embryonic stem cells remain embryonic because of epigenetic factors
4. From GM farm animals to embryonic stem cell research
5. Researchers discover important tool in understanding differentiation in human embryonic stem cells
6. Simple recipe turns human skin cells into embryonic stem cell-like cells
7. Oosight microscope enables embryonic stem cell breakthrough
8. Human embryonic stem cell -- derived bone tissue closes massive skull injury
9. University of Pittsburgh cardiologists identify new cardiac arrest gene
10. Pennsylvania Hospital surgeon receives grant to develop molecular cardiac surgery
11. ESF EURYI award winner aims to stop cancer cells reading their own DNA
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Implanting embryonic cardiac cells prevents arrhythmias
(Date:11/10/2014)... appearing on U.S. store shelves in early 2010, and ... The small packets can be tossed into a washing ... or powder. The convenience, though, has come with risks ... at Nationwide Children,s Hospital found that from 2012 through ... children younger than 6 years of age swallowing, inhaling, ...
(Date:11/7/2014)... November 6, 2014 Leading Biometric companies ... mobile security revolutionizing online transactions.  Companies in focus today are: ... (NYSE: BABA ), Google Inc. (NASDAQ: ... Inc. (NASDAQ: EBAY ) and MasterCard Inc. (NYSE: ... and NXTDW), a biometric authentication company focused on the growing ...
(Date:11/6/2014)... asset for a predator. Except when that predator runs so ... relative to its size, is the fastest creature on Earth. ... per second (at about five miles per hour). The fastest ... sprinting gold from the tiger beetle, a person would have ... beetle has a problem. At peak speeds, everything becomes a ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6The tiger beetle: Too fast to see 2
... emission by living organisms, bioluminescence, is quite common, especially ... generated by chemical reactions in which oxygen molecules play ... reactions take place in special luminescent cells called photocytes. ... the intensity of light is regulated by nerve impulses, ...
... created an algorithm that meshes existing data to ... cells respond to stimuli. Using this new method, ... have analyzed alpha-synuclein toxicity to identify genes and ... of the alpha-synuclein protein in brain cells are ...
... February 22, 2009--Researchers at the Dana-Farber Cancer Institute ... the Centers for Disease Control and Prevention (CDC) ... (mAb) that neutralize an unprecedented range of influenza ... previous pandemic influenza viruses, and some seasonal influenza ...
Cached Biology News:New light shed on marine luminescence 2Calculating gene and protein connections in a Parkinson's disease model 2Calculating gene and protein connections in a Parkinson's disease model 3Calculating gene and protein connections in a Parkinson's disease model 4Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses 2Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses 3
(Date:11/21/2014)... November 20, 2014 The November 2014 ... as an open access journal featuring the following articles:, ... proteins to preserve photoresponsiveness in the retina , ... in situ hybridization using chromogenic substrates in zebrafish , ... RNA, and protein electrophoresis , Nuclear LC3-positive ...
(Date:11/21/2014)... 2014 2014 Deep Research Report ... a professional and in-depth research report on the ... information, like its definition, classification, application, and industry ... report covers the international market analysis, including China’s ... the US, Europe, Asia, China, Japan etc. regions) ...
(Date:11/21/2014)... VANCOUVER , Nov. 20, 2014 /CNW/ - ... pleased to announce that it has closed a ... special warrants for approximately C$3.7 million.  Cormark Securities ... agents in the Brokered Offering for a syndicate ... and PI Financial Corp. (collectively the "Agents"). Concurrently ...
(Date:11/18/2014)... , Nov. 18, 2014 Cord Blood ... sponsor of the 10th Annual World Stem Cell Summit, the ... stakeholders. The 2014 World Stem Cell Summit will be held ... Antonio, Texas . The World ... development of lifesaving cures and therapies, convening the most prominent ...
Breaking Biology Technology:BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Aequus Pharmaceuticals closes $4.2 million private placement financing 2Aequus Pharmaceuticals closes $4.2 million private placement financing 3Cord Blood Registry Sponsors 2014 World Stem Cell Summit 2Cord Blood Registry Sponsors 2014 World Stem Cell Summit 3
... BEACH, Va., Oct. 7, 2011 Amerigroup Corporation ... launch of an innovative pilot program in Texas designed to ... is teaming up with Warm Health® to provide automated statewide ... and enhance the current high-risk maternity program in the Dallas ...
... NEW YORK, Oct. 6, 2011 A new invention ... αScreen is a portable, rapid pathogen screener that ... produced in processing plants, before it is delivered to ... low as a single bacteria, and is approximately 50 ...
... 2011 ProteinSimple today announced the launch of ... monitoring of protein-based therapeutics. The iCE3 platform will ... October 9-13, 2011, at Amelia Island, FL. ... purity closely. Imaged capillary electrophoresis (iCE) systems detect ...
Cached Biology Technology:Amerigroup Enhances Maternal Outreach Efforts 2Amerigroup Enhances Maternal Outreach Efforts 3Breakthrough in Preventing Food-borne Illnesses Wins $20,000 Grand Prize in Global Design Contest 2Breakthrough in Preventing Food-borne Illnesses Wins $20,000 Grand Prize in Global Design Contest 3Breakthrough in Preventing Food-borne Illnesses Wins $20,000 Grand Prize in Global Design Contest 4ProteinSimple Launches New System for Protein Biologics 2
... Rack inserts fit into the ... allow you to greatly increase ... deepwell format plates at an ... from the shaker at once ...
...
Mixing speed from 750-3200RPM, small vortexing orbit of1.0mm...
Request Info...
Biology Products: