Navigation Links
Impaired transport in neurons triggers prion disease
Date:8/21/2009

A new study shows that nervous system integrity and axonal properties may play a key role in prion diseases. The findings, from researchers at the Rudolf Virchow Center and the Institute of Virology of the University of Wrzburg, expand our understanding of the development of prion disease and suggest novel targets for therapeutic and diagnostic approaches in its early stages. Details are published August 21 in the open-access journal PLoS Pathogens.

Despite growing awareness of prion diseases, such as bovine spongiform encephalopathy (BSE) and the human variant, Creutzfeldt-Jakob disease, the molecular mechanisms responsible for their development are still not completely understood. These diseases are associated with neuropathological symptoms that include dementia, motor system defects and amnesia, although previous observations identified molecular hallmarks in the absence of these neuropathological symptoms, creating a paradox. The recent work of Vladimir Ermolayev and colleagues helps resolve this paradox, bringing new insights into the key factors triggering the onset of the clinical disease.

Impaired axonal transport is known to be involved in the development of neurodegenerative disorders like Alzheimer's or Parkinson's diseases. Previously, prion infections were shown to cause spongiform vacuolations, axonal swellings and accumulation of amyloid protein fibrils. Impaired axonal transport had not been observed so far. To monitor the axonal transport, Ermolayev and co-authors injected special dyes into mouse motor neurons, using a combination of confocal and novel ultramicroscopy techniques to monitor the dye delivery to the neurons and characterize the functional properties of axonal transport.

After prion injection into the brain and motor neuron system, Ermolayev and colleagues observed the described clinical symptoms. When clinical symptoms occurred, the researchers found a clearly reduced axonal transport in the neurons of two brain centers, the red nucleus and the motor cortex. Axonal transport impairments were seen in 45 per cent of neurons in the red nucleus and up to 94 per cent of motor cortex neurons.

"These results will help us to find better ways for diagnosis and treatment of prion diseases," says Dr. Vladimir Ermolayev.


'/>"/>

Contact: Sonja Juelich-Abbas
sonja.juelich@virchow.uni-wuerzburg.de
49-093-120-148-714
Public Library of Science
Source:Eurekalert

Related biology news :

1. Lack of happiness hormone serotonin in the brain causes impaired maternal behavior in mice
2. After a few drinks, older adults more impaired than they think
3. Impaired energy metabolism linked with initiation of plaques in Alzheimers brain
4. Scientists identify cell changes leading to impaired artificial kidney function
5. Telescope embedded in glasses lens promises to make driving easier for visually impaired
6. University of Houston diesel testing center teams with state transportation agency to cut emissions
7. Simulating pharmaceutical and personal care product transport
8. Transport behavior of E. coli varies depending on manure source
9. Transportation fuels of the future: Nottingham leads the way
10. Root system architecture arises from coupling cell shape to auxin transport
11. Root system architecture arises from coupling cell shape to auxin transport
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/3/2016)... -- --> --> Fourth quarter 2015: ... 1,187% compared with fourth quarter of 2014. Gross margin was ... 30.0). Earnings per share increased to SEK 6.39 (loss: 0.49). ... 74.7). , --> --> ... M (233.6), up 1,142% compared with 2014. Gross margin was ...
(Date:2/3/2016)... 2016 http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ... "Emotion Detection and Recognition Market by ... Software Tools (Facial Expression, Voice Recognition and ... - Global forecast to 2020" report ... http://www.researchandmarkets.com/research/d8zjcd/emotion_detection ) has announced the addition of ...
(Date:2/2/2016)... Feb. 2, 2016 Checkpoint Inhibitors for ... Market Are you interested in the future ... for checkpoint inhibitors. Visiongain,s report gives those predictions ... and national level. Avoid falling behind in ... opportunities and revenues those emerging cancer therapies can ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... ... February 10, 2016 , ... ... registry built on the secure online PatientCrossroads platform, has exceeded both its one-year ... have joined the PROMPT study, which seeks to advance understanding of the hereditary ...
(Date:2/10/2016)... CA (PRWEB) , ... February 10, 2016 , ... Cenna ... agents for the treatment of Alzheimer’s disease, announced today it has been selected to ... 18th at the Breakers in Palm Beach, Florida. The purpose of the Forum ...
(Date:2/9/2016)... , Feb. 9, 2016  Regenicin, Inc. (OTC ... specializing in the development and commercialization of regenerative ... tissues and organs, recently reported the Company,s operating ... quarter of 2016. Lonza America , ... 2015 fiscal year in the process of consummating ...
(Date:2/9/2016)... , ... February 09, 2016 , ... ... latest innovations on its free and validated Electronic Data Capture (EDC) system ClinCaptureand ... Outsourcing in Clinical Trials West Coast 2016 Conference in San Mateo, California on ...
Breaking Biology Technology: