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Impaired recovery from inflammation linked to Alzheimer's
Date:2/14/2014

p>"Our hypothesis is that stimulation of resolution of inflammation in Alzheimer's disease may result in reduced neuronal death in the brain, and in turn have a beneficial effect in disease progression and cognition. This is an entirely new approach and provides the opportunity to develop new treatment principles for Alzheimer's disease," says Professor Marianne Schultzberg, who led the study at the Department of Neurobiology, Care Sciences and Society.

In ongoing studies, the researchers are now investigating how the pro-resolving molecules affect neuronal death in cell cultures, and whether treatment in animal experiments with these substances can prevent neurodegeneration and improve memory functions. The pro-resolving molecules identified so far are derivatives of omega-3 fatty acids, which constitute a popular food supple-ment that has been ascribed several health benefits, and have received attention for beneficial effects also on factors related to Alzheimer's disease, in line with the new results described above. In previous studies, the researchers behind these new findings have shown that omega-3 also stimulates cells to take up amyloid-beta, a protein that kills neurons and occurs in the brain in the form of plaques in Alzheimer's disease.


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