Navigation Links
Impaired brain connections traced to schizophrenia mutation
Date:3/31/2010

terial, called a microdeletion, has repeatedly turned up in genetic studies of schizophrenia and is an indisputable risk factor for the illness.

Still, the mutation's link to the disturbed connectivity and working memory deficit eluded detection until now.

To explore the mutation's effects on brain circuitry, Gogos, Karayiorgou and colleagues engineered a line of mice expressing the same missing segment of genetic material as the patients. Strikingly, like their human counterparts with schizophrenia, these animals turned out to have difficulty with working memory tasks holding information in mind from moment to moment.

Successful performance of such tasks depends on good connections in a circuit linking the prefrontal cortex and the hippocampus. To measure such functional connections, Gordon and colleagues monitored signals emitted by single neurons implanted in the two distant brain structures while mice performed a working memory task in a T-maze (see below).

The more in-sync the neurons from the two areas fired, the better the functional connections between the two structures and the better the mice performed the task. Moreover, the better the synchrony to start with, the quicker the animals learned the task. The more synchrony improved, the better they performed.

As suspected, the mice with the chromosome 22 mutation faltered on all counts -- showing much worse synchrony, learning and performance levels than control mice.

"Our results extend beyond those in patients by showing how an undeniable genetic risk factor for schizophrenia can disrupt connectivity at the level of single neurons," explained Gordon.

The researchers plan to follow up with studies into how the mutation affects brain anatomical and molecular connections and the workings of affected genes.


'/>"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Impaired transport in neurons triggers prion disease
2. Lack of happiness hormone serotonin in the brain causes impaired maternal behavior in mice
3. After a few drinks, older adults more impaired than they think
4. Impaired energy metabolism linked with initiation of plaques in Alzheimers brain
5. Scientists identify cell changes leading to impaired artificial kidney function
6. Telescope embedded in glasses lens promises to make driving easier for visually impaired
7. New brain nerve cells key to stress resilience, UT Southwestern researchers find
8. Insulin-like signal needed to keep stem cells alive in adult brain
9. New understanding of proteins role in brain
10. New period of brain plasticity created with transplanted embryonic cells
11. Sex on the brain: Doublesex gene key to determining fruit fly gender
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Impaired brain connections traced to schizophrenia mutation
(Date:11/18/2014)... -- The Parenteral Drug Association (PDA) today confirmed that seven ... at least seven more will participate in the upcoming 2014 ... in Washington D.C. , Dec. 2-4. ... from the regulatory agencies in the United States ... effort to help advance the use of metrics in the ...
(Date:11/15/2014)... we may still be a few years away from the ... gain instant access to all that ailed his patients, mobile ... for monitoring and measuring our health are cropping up in ... tad Orwellian to some, but a new survey suggests that ... into their healthcare regime. These are some of ...
(Date:11/11/2014)... 2014  Forensicon, Inc., a Chicago ... announce the promotion of Yaniv Schiff from ... In Schiff,s new role as Director, he will lead ... forensics examiners and provide leadership within the company,s digital ... http://photos.prnewswire.com/prnh/20141110/157719 Schiff joined Forensicon in ...
Breaking Biology News(10 mins):FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Americans May Be Ready for a Brave New World of Healthcare 2Americans May Be Ready for a Brave New World of Healthcare 3Americans May Be Ready for a Brave New World of Healthcare 4Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... SAN DIEGO, Aug. 7 Sony is making the ... DSC-T77 digital,cameras with "intelligent" shooting functions., The 10-megapixel ... 5/8,of an inch with a 3-inch, 16 x 9 ... technology, Smile Shutter(TM) and,face detection technologies with child and ...
... University of Florida College of Pharmacy researchers have discovered ... that inhibits cancer cell growth in laboratory tests, a ... drugs to better battle the disease. The UF-patented ... coral reefs. Researchers, who described results from early studies ...
... Aug. 7, 2008 Despite some improvements to lower ... to do a better job controlling overall blood lipid ... Program study. Researchers found that 37 percent of ... system had reached recommended levels of LDL-C (bad cholesterol), ...
Cached Biology News:Sony Cyber-shot Cameras Get Smarter 2Sony Cyber-shot Cameras Get Smarter 3Researchers find cancer-inhibiting compound under the sea 2Researchers find cancer-inhibiting compound under the sea 3People with heart disease still have trouble controlling blood lipid levels 2
(Date:11/26/2014)... YORK, NOVEMBER 21, 2014 (PRWEB) November 26, 2014 ... largest health-oriented communications network, today announced the organization has ... Annual Rx Club Awards. Digitas Health LifeBrands was honored ... while four other PHCG agencies received eight Awards of ... the creative aspects of pharmaceutical advertising and promotion. The ...
(Date:11/26/2014)... 2014 The North America Thermal ... market for detailed analysis of the growth trends ... reach $616.3 million by 2018, growing at a ... Browse through the TOC of the North America ... idea of the in-depth analysis and industry segmentation ...
(Date:11/26/2014)... PHILADELPHIA , Nov. 26, 2014 ... environments. Human exploration of space requires astronauts to maintain ... safety and success, and prevent potential errors and accidents. ... little is known about how cognition is affected by ... affected. Now, Penn Medicine researchers are poised ...
(Date:11/26/2014)... The ETC (Emerging Technology Centers) ... centers, announced today that applications for AccelerateBaltimore™ (AB) ... “Do you have a big idea?,” asked ETC’s ... know about it. AccelerateBaltimore helps you and your ... just 13 weeks.” Interested game changers with ...
Breaking Biology Technology:Publicis Healthcare Wins 20 Rx Club Awards 2Publicis Healthcare Wins 20 Rx Club Awards 3The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 2The North America Thermal Protective Clothing Market is estimated to grow up to $616.3 million by 2018 - Report by MicroMarket Monitor 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 2Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 3Penn Medicine Team Develops Cognitive Test Battery to Assess the Impact of Long Duration Spaceflights on Astronauts' Brain Function 4AccelerateBaltimore Applications to Close in 6 Days 2AccelerateBaltimore Applications to Close in 6 Days 3
... ... sales success need to understand Key Performance Indicators (KPIs) that gauge the potential for ... to generate more business and income in a new article at www.YouCanSell.com . ... Albuquerque, NM ...
... ... In the India, CJP is all set to hold ... 20-24, 2010. The JatrophaWorld Training Programme 2010-- the Most Authoritative platform ... R&D progress, and application technologies, including utilization of Jatropha Crude Oil ...
... can operate efficiently and last a long time is a ... to the assembly line. The precious metal platinum has been ... downsides: It is expensive, and it breaks down over time ... Brown University report a promising advance. They have created a ...
Cached Biology Technology:Use Key Performance Indicators to Generate Sales Success Says Expert Lenann McGookey Gardner 2JatrophaWorld Training Programme Slated for India September 20-24, 2010 2JatrophaWorld Training Programme Slated for India September 20-24, 2010 3JatrophaWorld Training Programme Slated for India September 20-24, 2010 4Brown chemists report promising advance in fuel-cell technology 2
...
...
... to Decorin ( Abpromise for ... Antigen: Synthetic peptide: IGPEVPDDRDFEPS conjugated ... 6-19 of Human Decorin (fragment 36-49 ... II). Entrez GeneID: ...
...
Biology Products: