Navigation Links
Impaired brain connections traced to schizophrenia mutation
Date:3/31/2010

terial, called a microdeletion, has repeatedly turned up in genetic studies of schizophrenia and is an indisputable risk factor for the illness.

Still, the mutation's link to the disturbed connectivity and working memory deficit eluded detection until now.

To explore the mutation's effects on brain circuitry, Gogos, Karayiorgou and colleagues engineered a line of mice expressing the same missing segment of genetic material as the patients. Strikingly, like their human counterparts with schizophrenia, these animals turned out to have difficulty with working memory tasks holding information in mind from moment to moment.

Successful performance of such tasks depends on good connections in a circuit linking the prefrontal cortex and the hippocampus. To measure such functional connections, Gordon and colleagues monitored signals emitted by single neurons implanted in the two distant brain structures while mice performed a working memory task in a T-maze (see below).

The more in-sync the neurons from the two areas fired, the better the functional connections between the two structures and the better the mice performed the task. Moreover, the better the synchrony to start with, the quicker the animals learned the task. The more synchrony improved, the better they performed.

As suspected, the mice with the chromosome 22 mutation faltered on all counts -- showing much worse synchrony, learning and performance levels than control mice.

"Our results extend beyond those in patients by showing how an undeniable genetic risk factor for schizophrenia can disrupt connectivity at the level of single neurons," explained Gordon.

The researchers plan to follow up with studies into how the mutation affects brain anatomical and molecular connections and the workings of affected genes.


'/>"/>

Contact: Jules Asher
NIMHpress@nih.gov
301-443-4536
NIH/National Institute of Mental Health
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Impaired transport in neurons triggers prion disease
2. Lack of happiness hormone serotonin in the brain causes impaired maternal behavior in mice
3. After a few drinks, older adults more impaired than they think
4. Impaired energy metabolism linked with initiation of plaques in Alzheimers brain
5. Scientists identify cell changes leading to impaired artificial kidney function
6. Telescope embedded in glasses lens promises to make driving easier for visually impaired
7. New brain nerve cells key to stress resilience, UT Southwestern researchers find
8. Insulin-like signal needed to keep stem cells alive in adult brain
9. New understanding of proteins role in brain
10. New period of brain plasticity created with transplanted embryonic cells
11. Sex on the brain: Doublesex gene key to determining fruit fly gender
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Impaired brain connections traced to schizophrenia mutation
(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
(Date:12/4/2014)... Fla. , Dec. 3, 2014  Crossmatch™, ... today announced that its DigitalPersona ® Pro ... readers have been deployed throughout First Bank branch ... South Carolina and Virginia. First ... Southern Pines, North Carolina , ...
(Date:12/3/2014)... , Dec. 2, 2014 As part ... readers, Inception Technologies is pleased to announce the release ... for customers to collect the workforce data that they ... that have been left by existing readers. Many such ... interface, connectivity and modern technology. Older models force users ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3Inception Technologies to Release New Biometric Reader 2
... turned off or left on in healthy ... common cancers and maybe help avoid them, Medical College ... alterations, called DNA methylation, in the body,s basic building ... and their cancerous counterpart to find telltale patterns that ...
... A new study finds that most older long-term cancer survivors ... health habits. The study also reveals that those survivors ... health and quality of life. Published in the September 1, ... the American Cancer Society, the research indicates that greater efforts ...
... The results of a national assessment of indoor location ... announced at Worcester Polytechnic Institute (WPI) during the 2009 ... Emergency Responders, which runs from Aug. 3 to 4. ... with funding from the Department of Homeland Security and ...
Cached Biology News:Cancer's distinctive pattern of gene expression could aid early screening and prevention 2Cancer's distinctive pattern of gene expression could aid early screening and prevention 3Cancer's distinctive pattern of gene expression could aid early screening and prevention 4Most older long-term cancer survivors have poor health habits 2Results of national assessment of first responder location systems to be announced Aug. 3 2Results of national assessment of first responder location systems to be announced Aug. 3 3Results of national assessment of first responder location systems to be announced Aug. 3 4
(Date:12/24/2014)... SoundConnect’s 2015 ... introduce cutting edge communication technology, provide continued ... platform upgrades. This webinar series demonstrates online ... their quest to leverage web conferencing’s most ... SoundConnect’s Marketing Manager, Seanna Baumgartner, “Our webinars ...
(Date:12/24/2014)... report expects global cell isolation and expansion market to ... carefully analyzed data about the vital drivers, restraints, trends, ... Copy of Report @ http://bit.ly/1yUxy0T , According ... will keep witnessing growth at an impressive CAGR during ... by rapid technological advancements, government funding and investments, and ...
(Date:12/24/2014)... LOUIS , Dec. 23, 2014 ... today that the waiting period under the Hart-Scott-Rodino ... the acquisition expired on December 22, 2014, thereby ... review requirement for the acquisition of the Company ... U.S. antitrust clearance satisfies another condition to closing ...
(Date:12/22/2014)... RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), a ... of autologous cell therapies, announced today the publication of ... conjunction with co-authors from Kyoto University and the University ... clinical research using dermal sheath cup (DSC) cells to ... paper entitled " Hair Follicle Dermal Stem Cells Regenerate ...
Breaking Biology Technology:SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 2The Cell Expansion Market is Expected to Reach $14.8 billion by 2019 - New Research Report by MarketsandMarkets 3Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5
... Calif., May 12 An audit of the,state ... flaws,in Proposition 71 that created the agency, Consumer ... State Controller John Chiang found that with a,relatively ... complies with the requirements of Proposition 71, the,initiative ...
... May 12 Idenix,Pharmaceuticals, Inc. (Nasdaq: IDIX ) ... at the Rodman & Renshaw 5th Annual Global,Healthcare Conference ... at Le,Meridien Beach Plaza Hotel in Monte Carlo, Monaco., ... presentation can be,accessed under "Calendar of Events" in the ...
... FREEPORT, N.Y., May 12 "What,s the difference ... repair my DNA?" Hundreds of,women are trying to ... will give me beautiful, healthy skin?, Bio-scientist ... care expertise -- more than 20 years of ...
Cached Biology Technology:Controller's Stem Cell Agency Audit Ignores California Agency's Built-in Flaws 2Controller's Stem Cell Agency Audit Ignores California Agency's Built-in Flaws 3A Scientist Dechipers the Code to Beautiful, Healthy Skin in 'The New Science of Perfect Skin' 2
RABBIT ANTI WARFARIN...
For the quantitative determination of canine Interferon gamma,(IFN-γ) concentrations in cell culture supernates, serum and,plasma....
For the development of an immunoprecipitation assay to measure Chk1 kinase activity in cell lysates....
Bovine Serum Albumin Peroxidase Stabilizer Solution, 1 L...
Biology Products: