Navigation Links
Immunotherapy in high-risk pediatric sarcomas shows promising response
Date:7/31/2008

immunologic approach to exploit this window of opportunity," she said.

Both ESFT and AR develop due to chromosomal translocations, which fuse a gene from one chromosome to a different chromosome. The dendritic vaccine included peptides derived from each patient's individual cancer in a way that was designed to alert a patient's immune system to the unique genetic alteration on the cancer cells.

In this clinical trial of 52 patients, researchers attempted to use immunotherapy as "consolidation" therapy that is, after standard therapy provided a remission. Patients underwent aphaeresis to harvest blood lymphocytes that were then frozen. From this, dendritic cells were later extracted. These are cells that present an antigen to T cells and other immune system fighters in order to elicit a response.

All patients then had chemotherapy, radiation or surgery, as appropriate, and in some cases a stem cell transplant to induce remission. The 30 patients who initiated immunotherapy received a common flu vaccine, as well as their own lymphocytes and their own dendritic cells, which had been infused with tumor antigens. Some of these patients also received interleukin-2, which stimulates activity of T cell lymphocytes.

"The good news was the surprisingly nice T cell response patients had to the flu vaccination, even relatively soon after completing chemotherapy," Mackall said. "That shows that the general idea of using immunotherapy following chemotherapy to prevent recurrence is not a flawed one. Chemotherapy depleted the immune system, but we could restore it."

The bad news, she added, is that the dendritic vaccine "was not very immunogenic. We have a long way to go to optimizing this vaccine." Current studies are underway to test a new version of the vaccine, which utilizes more mature dendritic cells and tumor lysate in lieu of the translocation peptides. Ultimately, effective immunotherapy requires that one is capable of repr
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Cancer immunotherapy shows long-term promise in lung cancer
2. Leading pediatrician addresses the future of childrens health
3. Pediatricians alerted to the developmental nature of underage drinking in special journal supplement
4. Research shows skeleton to be endocrine organ
5. Clones on task serve greater good, evolutionary study shows
6. Study shows link between alcohol consumption and hiv disease progression
7. Novel 3-D cell culture model shows selective tumor uptake of nanoparticles
8. New study shows greenback cutthroat trout involved in recovery effort misidentified
9. DNA analysis shows true dispersal of protozoa
10. New genetic research into nicotine addiction shows promise for personalized treatment
11. International team shows mercury concentrations in fish respond quickly to increased deposition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... SALEM, N.C. , Dec. 10, 2014  That blood pressure ... quite a while. Hypertension – the medical term for high ... the early 1800s, and the inflatable cuff that,s used in ... doesn,t, however, mean there,s nothing new about hypertension, its triggers ...
(Date:12/10/2014)... here before: you desperately need to sign into your online banking ... to your secret question. What,s your dog,s birthday? Who was your ... a digital infrastructure security company, launches the app that ... usernames, passwords and PINs – 1U TM . 1U ...
(Date:12/10/2014)... , Dec. 9, 2014  Wake Forest Baptist Medical Center today ... School of Medicine. Funding for this $50 million capital project ... publicly launched next summer. The medical education ... Reynolds Tobacco Company complex, adjacent to 525@vine in Wake Forest ...
Breaking Biology News(10 mins):Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4
... This press release is available in German . ... the most fascinating species of the Galapagos archipelago, treks ... the Max Planck Institute for Ornithology in Radolfzell, together ... and modern 3D acceleration measurements to find out that ...
... becoming cannier about turning down the thermostat to save our ... when we get to work? A new 1.3m project, ... to look at people,s attitudes to energy consumption in the ... reducing their organisation,s carbon footprint. Drawing on technical expertise ...
... Elsevier, a world-leading provider of scientific, technical and medical ... new, international, open access journal, Case Studies in ... in Engineering Failure Analysis provides a forum for ... in Engineering Failure Analysis and will form an ...
Cached Biology News:Galapagos tortoises are a migrating species 2Galapagos tortoises are a migrating species 3An energy conscious workforce: New research looks at how to encourage staff to go green 2Elsevier launches new open access journal -- 'Case Studies in Engineering Failure Analysis' 2
(Date:1/22/2015)... Calif. , Jan. 22. 2015  Varian Medical Systems (NYSE: ... software, has been honored for its commitment to sustainability with ... companies. Varian is the highest ranked healthcare equipment company among ... today during the World Economic Forum at Davos, ...
(Date:12/25/2014)... The report “Service Quality Management and ... Provider Type - Global Advancements, Worldwide Forecasts & Analysis ... analysis and forecasting of revenues. , Browse 152 ... and in-depth TOC on “Service Quality Management (SQM) and ...
(Date:12/24/2014)... 2014  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical ... that the Company closed its previously announced private ... Jack W. Schuler , Birchview Fund LLC and ... before offering expenses.  The proceeds will be used ...
(Date:12/24/2014)... December 23, 2014 GMO corn cases filed ... are in the process of being consolidated in a Kansas ... Re: Syngenta AG MIR 162 Corn Litigation, MDL No. 2591 ... , Management of the Syngenta GMO corn multidistrict litigation (MDL) ...
Breaking Biology Technology:Varian Honored Among World's 100 Most Sustainable Corporations 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2
... ... first ever evidence of nuclear gene transfer from host to parasite plant species. The discovery, ... plant evolution. , ... UK) May 27, 2010 -- A research team at RIKEN, Japan’s flagship research organization, has ...
... , , ... /PRNewswire-FirstCall/ - Mr. Richard Gilbertson reports: , ... "Developed nations, especially urban areas, once enjoyed a significant communications and ... location, without connectivity to the rest of the world? With reasonably priced connectivity, ...
... BEIJING , May 27 /PRNewswire-Asia-FirstCall/ -- Concord Medical ... ), the,operator of the largest network of radiotherapy and diagnostic imaging ... the first,quarter ended March 31, 2010 (1). , , ... Total net revenues in the first quarter of 2010 were RMB76.2 ...
Cached Biology Technology:Parasite plants rob genes from their hosts 2IGEN engages investor relations firm and announces private placement 2IGEN engages investor relations firm and announces private placement 3Concord Medical Announces First Quarter 2010 Financial Results 2Concord Medical Announces First Quarter 2010 Financial Results 3Concord Medical Announces First Quarter 2010 Financial Results 4Concord Medical Announces First Quarter 2010 Financial Results 5Concord Medical Announces First Quarter 2010 Financial Results 6Concord Medical Announces First Quarter 2010 Financial Results 7Concord Medical Announces First Quarter 2010 Financial Results 8Concord Medical Announces First Quarter 2010 Financial Results 9Concord Medical Announces First Quarter 2010 Financial Results 10Concord Medical Announces First Quarter 2010 Financial Results 11Concord Medical Announces First Quarter 2010 Financial Results 12Concord Medical Announces First Quarter 2010 Financial Results 13Concord Medical Announces First Quarter 2010 Financial Results 14Concord Medical Announces First Quarter 2010 Financial Results 15
... intended for laboratory research use only. ... buffered formalin and embedded in paraffin. ... certified pathologists. Tissue cores were removed ... a new recipient paraffin block, in an ...
... the industry standard microarray image analysis software ... and analysis tools, visualizations, automation capabilities, performance ... included with every GenePix scanner, and it ... and all types of arrays. A wide ...
... applications not requiring confocal, the BD Pathway ... the Pathway 435. And, the Pathway 415 ... applications require it. High-performance, ... to use the laser autofocus, camera autofocus, ...
... in a single and twin head, features T ... the most compact, lightweight package in its performance ... air and gas applications., Available in single ... Delivers 1.5 and 2.0 liters per Watt @ ...
Biology Products: