Navigation Links
Immunosuppressant further linked to birth defects
Date:2/6/2008

born Research Unit at the Hospital Universitario Materno-Infantil La Fe, in Valencia, Spain, the study describes a 25-year-old Spanish woman who had undergone two kidney transplants. Following the second transplant she took the immunosuppressant drugs tacrolimus and MMF. Two years later she became pregnant and MMF was discontinued at 10 weeks gestation, while tacrolimus, one of the drugs that has been studied in pregnant women, was maintained. She delivered a female infant who had cleft lip and palate, as well as defects of the jaw, eyes and ears, including no external ear canals. At nine months her child was developing normally, although she needed hearing aids.

The pattern of defects seen in this infant is very similar to previous reports of birth defects in infants who were exposed to MMF in utero. The study describes these infants, noting that the pattern of cleft lip/palate and ear malformations was seen in every case but one. Although defects of the eye had not been seen in humans before, studies in rats and rabbits have shown ocular malformations following exposure to MMF. The authors suggest that the pattern of defects seen with MMF establishes a possible link between use of this drug during pregnancy and a specific malformation pattern in structures derived from the frontal-nasal prominence (which develops into the forehead, nose, upper lip and palate) and the first pharyngeal arch (which develops into the jaw and ear).

It should be noted, however, that if a transplant recipient is of fertile age, she can give birth to a healthy baby. The patient needs to be adequately counseled, and withdraw from immunosuppressants that may be deleterious to the baby within sufficient of becoming pregnant to avoid any interference during the first 12 weeks of gestation, says Dr. Maximo Vento, co-author of the study.


'/>"/>

Contact: Sean Wagner
swagner@bos.blackwellpublishing.com
781-388-8550
Blackwell Publishing Ltd.
Source:Eurekalert

Page: 1 2

Related biology news :

1. Further development of Water Framework Directive necessary
2. Further breakthroughs for breast cancer patients
3. Worlds largest investor coalition seeks further disclosure on climate change and shareholder value
4. Risk of common vaginal infection linked to preterm birth appears higher for blacks
5. Scientists show that mitochondrial DNA variants are linked to risk factors for type 2 diabetes
6. Protein chatter linked to cancer activation
7. Western diet linked to increased risk of colon cancer recurrence
8. Sugary drinks, not fruit juice, may be linked to insulin
9. Brains timing linked with timescales of the natural visual world
10. Low vitamin D during pregnancy linked to pre-eclampsia
11. Genetic variant linked to odor perception
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... TURKU , Finnland, October 1, 2014 ... der Durchbruch im Bereich der Biowissenschaften   ... Jahren ein Kommen und Gehen zahlreicher Detektionstechnologien. ... sich zum goldenen Standard. Die Photonen-Upconversion ist ... den letzten Jahren mit Begeisterung aufgenommen wurde. ...
(Date:9/30/2014)... effects of moorland burning is published today in the ... aim of relieving tensions on both sides of the ... of Moorland Burning on the Ecohydrology of River basins) ... is practised predominantly to support red grouse populations for ... peat chemistry and physical properties, river water chemistry and ...
(Date:9/30/2014)... seedless watermelon, salmon, and strawberries all have in common? ... sets of chromosomes and are diploid, these organisms are ... of chromosomesseedless watermelon and salmon have 3 and 4 ... While this might seem surprising, in fact most plant ... discovered over a century ago, but only recently, with ...
Breaking Biology News(10 mins):Innovative Verwendungslösung für die Photonen-Upconversion 2Innovative Verwendungslösung für die Photonen-Upconversion 3Grouse moor burning causes widespread environmental changes 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4
... that has wiped out more than 100 species, scientists at ... species in Panama: Pristimantis educatoris , from Omar Torrijos ... near the Colombian border. , In 1989 researchers realized that ... cause: a fungal disease called chytridiomycosis. In 2004 Karen Lips, ...
... than two million miles of the nation,s ... nearing the end of its useful life, ... not attract much attention because of this ... professor of civil and environmental engineering (CEE). ...
... at Oregon State University have made an important fundamental advance ... not only can walk and run effectively, but use little ... with robotic mechanisms, studies are moving closer to robots that ... limbs for humans that work much better, or even help ...
Cached Biology News:2 new frog species discovered in Panama's fungal war zone 2Efforts underway at Virginia Tech to address deterioration of nation's water pipes 2Advances made in walking, running robots 2Advances made in walking, running robots 3
(Date:10/1/2014)... Francisco, California (PRWEB) October 01, 2014 ... from the National Science Foundation to expand their bioCAD/CAM ... to build and modify DNA. The Small Business Innovation ... commercialize the “j5” technology under exclusive license from the ... Joint BioEnergy Institute , an LBNL laboratory that ...
(Date:10/1/2014)... , October 1, 2014 ... software invited to engage around the theme, ,Commercial Opportunities ...   Elsevier , a ... and services, will host a gathering of some of ... and trends impacting healthcare today and in the future. ...
(Date:9/30/2014)... news release is available in German . ... the Technische Universitt Mnchen (TUM) have demonstrated a new ... experiments show that future computer chips could be based ... As the main enabling technology of the semiconductor industry ... limits, the TUM researchers and collaborators at the University ...
(Date:9/30/2014)... , Sept. 30, 2014 Report Details ... with highest potential revenues Do you want to ... gives you revenue predictions for those biological drugs ... therapies you find financial data, R&D trends, opportunities ... get sales forecasts to 2024 at overall world ...
Breaking Biology Technology:TeselaGen Receives $750k NSF SBIR Phase II Award 2TeselaGen Receives $750k NSF SBIR Phase II Award 3Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5
... skills needed for the Information Age. Their administrations, as well ... way beyond the Industrial Age. , ,For the most ... not talking about reading, writing and `rithmetic; I am talking ... to regimentation, which is what was needed to assimilate people ...
... receive $1.5 million from the U.S. Department of Energy ... ethanol at paper mills by extracting the sugars from wood ... Akhtar, president of CleanTech Partners and principal investigator on the ... Other participants included the United States Department of Agriculture ...
... - The origins of Madison's technology industry can be ... isolated when he opened DNASTAR, Inc . that year. , ... - and a few more, the producer of DNA analysis ... era where it was considered bad form - even a social ...
Cached Biology Technology:Rote education fails the Information Age 2Rote education fails the Information Age 3Rote education fails the Information Age 4DNASTAR catches second wave of sequencing 2DNASTAR catches second wave of sequencing 3DNASTAR catches second wave of sequencing 4
...
... Dr. P Set from different Cynomolgus ... More organs maybe available upon request. ... items from the whole set, and ... price. All Dr. P Set ...
...
Immunogen: Recombinant full length protein, corresponding to amino acids 1-435 of Human AP2M1. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: