Navigation Links
Immunosignaturing: An accurate, affordable and stable diagnostic
Date:4/23/2012

Identifying diseases at an early, presymptomatic stage may offer the best chance for establishing proper treatment and improving patient outcomes. A new technique known as immunosignaturing harnesses the human immune system as an early warning sentryone acutely sensitive to changes in the body that may be harbingers of illness.

Now, Brian Andrew Chase and Barten Legutki, under the guidance of Stephen Albert Johnston, director of the Center for Innovations in Medicine at Arizona State University's Biodesign Institute have shown that these immunosignatures are not only strong indicators of pre-symptomatic illness, but that samples from serum, plasma, saliva and dried blood can yield reliable and highly stable diagnostic results under a variety of conditions.

As Johnston explains, the new data advance the prospects for applying immunosignaturing as a sensitive, low-cost, universal system for assessing health status. "Our ultimate goal is to monitor the health of healthy people, so it is crucial we have a technique that is cheap, simple and, as we demonstrate here, robust."

The group's results recently appeared in the journal Clinical and Vaccine Immunology.

Immunosignaturing uses random sequence arrays of peptides to trawl for antibodies to disease. Previous work has demonstrated that a glass slide containing an array of some 10,000 such random sequences, each composed of 20 amino acids, can be used to screen the body's full complement of antibodies, when a single drop of blood is spread over its surface.

When the antibodies present in a sample of blood are splayed over the peptide array, they selectively bind to these peptides with varying degrees of affinity. Once the blood is washed away, a machine-readable image of immune activity is left behindthe immunosignaturepotentially providing pre-symptomatic diagnosis for a broad range of ailments, from infectious diseases to chronic afflictions to varied fo
'/>"/>

Contact: richard.harth@asu.edu
richard.harth@asu.edu
Arizona State University
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis
2. Faster, more accurate, more sensitive
3. Ingenuity Systems iReport Now Available: Fast, Accurate, Interactive Report for Gene Expression Data
4. Purple Pokeberries hold secret to affordable solar power worldwide
5. Would convenient access to affordable fresh produce improve eating habits?
6. Reinventing the toilet for safe and affordable sanitation
7. On the road to creating an affordable master instrument
8. Affordable solar?
9. Trading energy for safety, bees extend legs to stay stable in wind
10. Evolution still scientifically stable
11. Stable climate and plant domestication linked
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immunosignaturing: An accurate, affordable and stable diagnostic
(Date:9/2/2014)... in Taiyuan, China, have substantially improved the health of ... reduction in costs associated with loss of life and ... the Columbia Center for Children,s Environmental Health (CCCEH) at ... University, the Center of Diseases Control and Prevention of ... Health. , The study is the first to document ...
(Date:9/2/2014)... of lithographic limestone is well known as a ... that area (for example, Archaeopteryx). Now, for the ... the French equivalent of these outcrops - discoveries ... known water treader. , Despite the abundance of ... have been obtained from the Late Kimmeridgian equivalents ...
(Date:9/2/2014)... done in by it. New research at Rockefeller University ... gap in mice with very similar genetic backgrounds ... the development of psychiatric disorders such as anxiety and ... as it goes through its life. And we suspect ... genes, and as a result, affect an animal,s susceptibility ...
Breaking Biology News(10 mins):Clean air halves health costs in Chinese city 2Exceptionally well preserved insect fossils from the Rhône Valley 2Discovery hints at why stress is more devastating for some 2Discovery hints at why stress is more devastating for some 3
... Cheryl Hayashi, a biologist at UC Riverside and a national ... a $500,000 MacArthur Fellowship, one of the most prestigious awards ... MacArthur Fellows for 2007 named by the John D. and ... award, the MacArthur Fellowship is a no strings attached grant ...
... help policy makers to estimate the consequences of various ... much toll must be charged for the desired policy ... all travellers or maximising the toll incomes (revenues). Based ... the impacts on road congestion and the total toll ...
... antimicrobials bind and thereby get inactivated in the mucus ... may have found a way to help cystic fibrosis ... this work has potential as a therapeutic strategy against ... professor of materials science and engineering, of physics, and ...
Cached Biology News:UC Riverside biologist receives prestigious MacArthur Fellowship 2UC Riverside biologist receives prestigious MacArthur Fellowship 3Cystic fibrosis patients may breathe easier, thanks to bioengineered antimicrobials 2
(Date:8/31/2014)... 31, 2014 2014 Market ... a professional and in-depth research report on ... Polyacrylamide information, including Polyacrylamide definition, classification, application, ... industry overview. This research covers the international ... as global industry analysis covering macroeconomic environment ...
(Date:8/30/2014)... The Global and China Electrical ... study on the current state of the Electrical ... The report provides a basic overview of the ... Global market analysis and Chinese domestic market analysis ... trends and competitive landscape of the market. A ...
(Date:8/29/2014)... based on electrons, but one of the most promising ... circuits based on light (photons) instead of electrons. First, ... stream of single photons and control their direction. Researchers ... to achieve this control, but now scientists at the ... stream of photons emitted one at a time and ...
(Date:8/29/2014)... According to a new market report published by Transparency ... valued at USD 3,754.6 million in 2012 and is estimated ... CAGR of 5.9% from 2013 to 2019. , Nearly half ... by bone and joint disorders, and this number is expected ... will continue to increase the demand for orthobiologics. Other factors ...
Breaking Biology Technology:International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 2Electrical Insulating Varnish Market World, China Regional Analysis & 2020 Forecasts Available at DeepResearchReports.com 3Breakthrough in light sources for new quantum technology 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 2Global Orthobiologics Market to Reach $5,519.9 Million by 2019: Transparency Market Research 3
... of Multi-Use Clearance for Axxent(R), System ... Radiation Therapy, SUNNYVALE, Calif., May 21 ... from the U.S. Food & Drug Administration,(FDA) for ... System for the treatment of endometrial cancer. Previously,cleared ...
... Co., Ltd. announced today,that it has entered into an ... a German biotechnology company focusing on research into,antibodies for ... 100 percent of the stock and make a,one-time payment ... Closure of the transaction is subject to clearance under ...
... world converge on Regenesis, SCOTTSDALE, Ariz., May ... that markets the Provant(R) Wound Therapy,System, announced today ... purpose is to guide advanced scientific investigations into ... and further,application of Regenesis, platform technology to clinical ...
Cached Biology Technology:FDA Clears New Applicators for Endometrial Cancer Treatment With Xoft's Axxent(R) Electronic Brachytherapy System 2FDA Clears New Applicators for Endometrial Cancer Treatment With Xoft's Axxent(R) Electronic Brachytherapy System 3FDA Clears New Applicators for Endometrial Cancer Treatment With Xoft's Axxent(R) Electronic Brachytherapy System 4Daiichi Sankyo Co., Ltd. Announces Acquisition of Biotech Firm U3 Pharma AG 2Daiichi Sankyo Co., Ltd. Announces Acquisition of Biotech Firm U3 Pharma AG 3Regenesis Biomedical Appoints Scientific Advisory Board Composed of Life Science and Electronics Experts 2Regenesis Biomedical Appoints Scientific Advisory Board Composed of Life Science and Electronics Experts 3
...
... Ferrofluid products perform optimally when ... Systems MagCellect Magnet. To accommodate ... iron boron permanent magnet holds ... mm test tubes or two ...
S. O'Hare & C.K. Atterwill • In vitro toxicity techniques for regular lab use. Ex vivo techniques are also covered with the aim of reducing and refining the use of animals in the future....
Agarase cleaves agarose to neoagaro-oligosaccharides, and is used for,quantitative, gentle recovery of DNA from low melting point agarose....
Biology Products: