Navigation Links
Immunological mechanisms of oncolytic adenoviral therapy
Date:1/26/2012

the therapeutic effects on cancer. Some studies have shown that suppressing the immune system could enhance the efficacy of oncolytic vectors. On the other hand, recent preclinical and clinical studies have suggested that the immune response plays an important role in mediating the antitumor efficacy. Therefore, the influence of immune responses on oncolytic therapy is complex. Because of the species specificity of adenoviral replication, it was widely assumed that adenoviral replication would not occur in mouse tumors. Consequently, oncolytic adenoviral vectors have been commonly evaluated in immunodeficient mouse-human tumor xenograft models, which do not accurately reflect what happens in humans treated with oncolytic adenovirus. A team led by Professor Yaohe Wang from the Center for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, previously screened a panel of mouse tumor cell lines and identified two cell linesCMT 93 (a murine rectal cancer cell line) and CMT64 (a murine non-small-cell lung cancer cell line) with significant permissibility for adenoviral gene expression, cytopathic effects, and/or replication.

In this work, the team lead by Professor Wang Shengdian evaluated the roles of immune components in oncolytic adenoviral therapy with a murine tumor by subcutaneously inoculating CMT 93 cells into syngeneic C57BL/6 mice. They found that CD8+ T cells, but not CD4+ T cells or natural killer cells, are critical mediators of the antitumor efficacy of oncolytic adenovirus by deletion of the corresponding cell subsets with specific antibodies. Intratumoral injection of adenovirus serotype 5 (Ad5) could induce intensive infiltration of CD8+ T cells into the tumor, and increase tumor-specific interferon-γ production and cytotoxic T lymphocyte activity. The anti-tumor T cell responses induced by Ad5 therapy produced long-term tumor-specific memory immune responses that protected the cured mice well from tumor rechallenge
'/>"/>

Contact: Wang Shengdian
sdwang@moon.ibp.ac.cn
0086-106-488-8493
Science in China Press
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Immunological defense mechanism leaves malaria patients vulnerable to deadly infection
2. Pitt/UPMC: Exceptional cognitive and physical health in old age leaves immunological fingerprint
3. Keystone Symposia to hold conference in Seattle on immunological mechanisms of vaccination
4. Research team discovers genes and disease mechanisms behind a common form of muscular dystrophy
5. Bone marrow-derived cells differentiate in the brain through mechanisms of plasticity
6. New leads on mechanisms that confer virulence to E.coli-type bacteria
7. Study identifies mechanisms cells use to remove bits of RNA from DNA strands
8. Milking the pigeon: extracting the mechanisms involved
9. Primary component in turmeric kicks off cancer-killing mechanisms in human saliva
10. New perspectives on sensory mechanisms
11. Novel analysis by Allen Institute sheds new light on the mechanisms of brain development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... acquire and creatively manipulate spoken language is unique to ... 6 million years of human evolution to make this ... candidate gene we now have," says Wolfgang Enard, Professor ... efforts to understand the molecular biological basis of language ... results of his latest study, undertaken in collaboration with ...
(Date:9/18/2014)... 18, 2014Many Americans across racial and ethnic groups ... impact on their day-to-day life, more so than ... and speech (57% of African-Americans, 49% of non-Hispanic ... When asked which disease or ailment is the ... first among African-Americans followed by AIDS/HIV. Hispanics ...
(Date:9/18/2014)... The global cycles of carbon and nitrogen comprise ... human and environmental systems have caused imbalances and ... greenhouse gases (GHGs). Increased GHGs result in climate ... terrestrial ecosystems, oceans and the atmosphere. Understanding these ... exciting branch of environmental science during the past ...
Breaking Biology News(10 mins):Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3Americans rate losing eyesight as having greatest impact on their lives 2Americans rate losing eyesight as having greatest impact on their lives 3Greenhouse gas research enters a new era 2
... attacks in the United States in 2001 the threat ... perhaps from smallpox, plague or tularemia -- became very ... and rapidly contain an attack is still being developed. ... Center for Quantum Devices have demonstrated solar-blind avalanche photodiodes ...
... than men despite the popular notion that the opposite is ... pain have found that not only do women report more ... it in more bodily areas, more often and for longer ... be differences in how men and women think and feel ...
... $52.7 million research program that will help reveal the ... and point the way to designing new medicines. Under ... Structural Genomics Consortium (NESG) will conduct the five-year undertaking. ... history, will reinforce our dynamic position in the biomedical ...
Cached Biology News:Tiny avalanche photodiodes target bioterrorism agents 2Women feel more pain than men, research shows 2Women feel more pain than men, research shows 3Rutgers to lead $52.7 million protein research program 2Rutgers to lead $52.7 million protein research program 3Rutgers to lead $52.7 million protein research program 4
(Date:9/18/2014)... 2014 Research and Markets ... N-acetylcysteine Industry Report 2014" report to their ... Report 2014 is a professional and in-depth study ... industry. The report provides a basic ... and industry chain structure. The N-acetylcysteine market analysis ...
(Date:9/18/2014)... Research and Markets has announced the addition ... In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to ... The global companion diagnostics market is expected to grow ... Factors such as rising need for personalized medicine in ... pharmaceutical industry, support from regulatory authorities, and emerging technologies ...
(Date:9/18/2014)... LOUIS , Sept. 18, 2014  U.S. biotech ... by signing an exclusive license for technology developed by ... control gene expression in plants, including for applications in ... The technology was developed under the ... officer at Kultevat and former president of the Danforth ...
(Date:9/18/2014)... , Sept. 18, 2014  Neogen Corporation (Nasdaq: ... entered into a strategic agreement with Merck Animal Health ... The Igenity Dairy Heifer Program consists ... information on the genetic potential of replacement dairy heifers. ... calf is born, and is an excellent tool in ...
Breaking Biology Technology:Global N-acetylcysteine Industry Report 2014 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 2Global Companion Diagnostics (Polymerase Chain Reaction, In-situ hybridization, Immunohistochemistry) Market - Trends & Forecasts to 2019 3Kultevat obtains license of gene switch technology 2Merck Animal Health to market Neogen's dairy genomic program 2
... Companies in Plant Biotechnology Industry, WILMINGTON, Del., Oct. ... one of the best employers in the biotechnology and,pharmaceutical ... This is the first DuPont appearance on the ... it ahead of other companies in the,plant biotechnology industry. ...
... 18 NPS,Pharmaceuticals, Inc. (Nasdaq: NPSP ) announced ... offer for any and all of its outstanding,3.0% Convertible ... New,York City time, on October 17, 2007. As ... million principal,amount of the notes, representing approximately 99.7% of ...
... -- Company Completes Enrollment in First Cohort --, ... Nventa,Biopharmaceuticals Corporation (TSX:NVN) today announced that the Company,has ... Phase 1 clinical trial,to assess the safety and ... neoplasia (CIN). The trial is expected to ...
Cached Biology Technology:DuPont Named Among Top Biotechnology Employers by Science Magazine 2NPS Pharmaceuticals Announces Results of Tender Offer 2NPS Pharmaceuticals Announces Results of Tender Offer 3Nventa updates progress of cervical dysplasia trial with new HspE7 2Nventa updates progress of cervical dysplasia trial with new HspE7 3Nventa updates progress of cervical dysplasia trial with new HspE7 4Nventa updates progress of cervical dysplasia trial with new HspE7 5
Mycoplasma and virus tested...
... MagicMark XP Western Protein Standards are ... protein molecular weight estimation directly on ... an IgG binding site, allowing direct ... used to detect your target protein ...
... Clone/PAD: 3F10B10. Immunogen: Synthetic ... region of JAB1 (Jun activation ... Specificity: Specific for the JAB1 ... controls: 293T Jurkat cell lysates). ...
...
Biology Products: