Navigation Links
Immunohistochemistry effectively detects ALK rearrangement
Date:6/25/2013

DENVER ALK rearrangement has been demonstrated to be a potent oncogenic driver and a promising therapeutic target in non-small cell lung cancer (NSCLC). It defines a distinct molecular subset of NSCLC, in particular adenocarcinoma that can benefit by the treatment of ALK-inhibitors. Development of robust and reliable laboratory tests for predictive biomarkers is essential to select appropriate patients for targeted therapy.

Researchers from the Chinese University of Hong King evaluated the practical usefulness of immunohistochemistry to detect ALK expression as a reliable detection method of ALK rearrangement in lung adenocarcinoma.

A study published in the July issue of the Journal of Thoracic Oncology (JTO), concludes that immunohistochemistry can effectively detect ALK rearrangement in lung cancer. In fact, it might provide a reliable and cost-effective diagnostic approach in routine pathologic laboratories for the identification of suitable candidates for ALK-targeted therapy. Researchers tested 373 lung adenocarcinomas for ALK rearrangement by immunohistochemistry (IHC) and fluorescent in situ hybridization, known as FISH.

They conclude that, "IHC would be served as an effective and rapid detection method in routine pathologic laboratories for the identification of suitable candidates for ALK-targeted therapy." IHC is a less complex and less costly technology than FISH.

In addition, their research demonstrated that some ALK IHC positive but FISH-negative lung cancers did harbor the translocation events as confirmed by RT-PCR. Thus, this subgroup of patients should also benefit from ALK inhibitory therapy. Further clinical trials are required to address the predictive value of ALK IHC in these patients.


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1

Related biology news :

1. MARC Travel Awards announced for Immunohistochemistry and Microscopy (IHCM) Short Course 2013
2. Study shows immunohistochemistry is reliable screening tool for ALK rearrangement
3. Food industrys high-quality co-streams used effectively as raw material for new products
4. Ecosystems cope with stress more effectively the greater the biodiversity
5. New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed
6. Non-invasive first trimester blood test reliably detects Downs syndrome
7. NLST: CT detects twice as many lung cancers as X-ray at initial screening exam
8. Biosensor that detects antibiotic resistance brings us one step closer to fighting superbugs
9. Measuring mercury levels: Nano-velcro detects water-borne toxic metals
10. Lab-on-a-chip detects trace levels of toxic vapors in homes near Utah Air Force Base
11. Made-in-Singapore H5N1 diagnostic kit -- detects all known strains of H5N1 virus with a single test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... DUBLIN , Feb. 5, 2016 /PRNewswire/ ... the addition of the "Global Facial ... offering. --> http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has ... Facial Recognition Market 2016-2020" report to ... Markets ( http://www.researchandmarkets.com/research/5kvw8m/global_facial ) has announced the ...
(Date:2/3/2016)... , Feb. 3, 2016 Vigilant Solutions ... Police Department in Missouri solved ... plate reader (LPR) data from Vigilant Solutions. ... case in which the victim was walking out of a convenience store and ... space next to his vehicle, striking his vehicle and ...
(Date:2/2/2016)... , Feb. 2, 2016 Checkpoint ... that Rising Market Are you interested in ... forecasts revenues for checkpoint inhibitors. Visiongain,s report gives ... submarket, product and national level. Avoid falling ... what progress, opportunities and revenues those emerging cancer ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... SAN DIEGO, Feb. 11, 2016  Neurocrine Biosciences, Inc. (NASDAQ: ... year ended December 31, 2015. --> ... reported a net loss of $29.3 million, or $0.34 loss per ... loss per share for the same period in 2014. For the ... of $88.9 million, or $1.05 loss per share, as compared to ...
(Date:2/11/2016)... Feb. 11, 2016  Wellcentive today announced it ... Portland, Oregon -based community care organization (CCO) ... health analytics, quality reporting and care management solutions ... its team of quality managers, analysts and care ... provider groups serving FamilyCare members. ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... 150 years, continues today to pursue the highest level of accuracy and quality ... the AR9 Refractometer and the AR5 Refractometer. Accurate, reliable and tough enough ...
(Date:2/10/2016)... -- The Maryland House of Delegates and House Speaker ... Maryland School of Medicine Dean E. Albert Reece ... System President and CEO Robert Chrencik , MBA, ... given to the public by the leader of the ... and Mr. Chrencik for their contributions to our statewide ...
Breaking Biology Technology: