Navigation Links
Immunohistochemistry effectively detects ALK rearrangement
Date:6/25/2013

DENVER ALK rearrangement has been demonstrated to be a potent oncogenic driver and a promising therapeutic target in non-small cell lung cancer (NSCLC). It defines a distinct molecular subset of NSCLC, in particular adenocarcinoma that can benefit by the treatment of ALK-inhibitors. Development of robust and reliable laboratory tests for predictive biomarkers is essential to select appropriate patients for targeted therapy.

Researchers from the Chinese University of Hong King evaluated the practical usefulness of immunohistochemistry to detect ALK expression as a reliable detection method of ALK rearrangement in lung adenocarcinoma.

A study published in the July issue of the Journal of Thoracic Oncology (JTO), concludes that immunohistochemistry can effectively detect ALK rearrangement in lung cancer. In fact, it might provide a reliable and cost-effective diagnostic approach in routine pathologic laboratories for the identification of suitable candidates for ALK-targeted therapy. Researchers tested 373 lung adenocarcinomas for ALK rearrangement by immunohistochemistry (IHC) and fluorescent in situ hybridization, known as FISH.

They conclude that, "IHC would be served as an effective and rapid detection method in routine pathologic laboratories for the identification of suitable candidates for ALK-targeted therapy." IHC is a less complex and less costly technology than FISH.

In addition, their research demonstrated that some ALK IHC positive but FISH-negative lung cancers did harbor the translocation events as confirmed by RT-PCR. Thus, this subgroup of patients should also benefit from ALK inhibitory therapy. Further clinical trials are required to address the predictive value of ALK IHC in these patients.


'/>"/>

Contact: Kristal Griffith
Kristal.Griffith@iaslc.org
720-325-2952
International Association for the Study of Lung Cancer
Source:Eurekalert

Page: 1

Related biology news :

1. MARC Travel Awards announced for Immunohistochemistry and Microscopy (IHCM) Short Course 2013
2. Study shows immunohistochemistry is reliable screening tool for ALK rearrangement
3. Food industrys high-quality co-streams used effectively as raw material for new products
4. Ecosystems cope with stress more effectively the greater the biodiversity
5. New Technology Using Biometrics Detects If Security Guards Are Attacked, Injured Or Killed
6. Non-invasive first trimester blood test reliably detects Downs syndrome
7. NLST: CT detects twice as many lung cancers as X-ray at initial screening exam
8. Biosensor that detects antibiotic resistance brings us one step closer to fighting superbugs
9. Measuring mercury levels: Nano-velcro detects water-borne toxic metals
10. Lab-on-a-chip detects trace levels of toxic vapors in homes near Utah Air Force Base
11. Made-in-Singapore H5N1 diagnostic kit -- detects all known strains of H5N1 virus with a single test
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... most numerous inhabitants of the sea: tiny haptophytes of ... the naked eye, when they are in bloom in ... even visible on satellite images. "Together with other phytoplankton, ... of the global photosynthesis output," states Prof. Dr. Georg ... the process the greenhouse gas carbon dioxide CO2 ...
(Date:7/8/2014)... 2014 Collectors found the first two specimens of the ... for two decades, the 14-inch-tall plant was identified wrongly as ... after a long search turned up a "pathetic, wilted" ... colleagues identified the spiny plant as a new, possibly endangered ... it was found in Valentine, Texas, population 134 in 2010. ...
(Date:7/8/2014)... greenhouse gases could be vulnerable to price spikes ... released by scholars affiliated with the Energy Institute ... prevent that outcome with three straightforward reforms, the ... Board should consider (1) strengthening the new market,s ... permits to be converted from one compliance period ...
Breaking Biology News(10 mins):Short circuit in the food web 2New plant species from the heart of Texas 2New plant species from the heart of Texas 3New plant species from the heart of Texas 4New plant species from the heart of Texas 5Three reforms to protect California's cap-and-trade policy 2
... human blood group that has remained a mystery for the past ... is responsible for the lack of this blood group in some ... blood group, medical scientists can now develop a more reliable DNA ... the risk of severe, and sometimes life threatening, destruction of the ...
... Florida State University College of Medicine has made discoveries ... how life first emerged on Earth billions of years ... supporting the idea that 10 amino acids believed to ... capable of forming foldable proteins in a high-salt (halophile) ...
... water quality studies to genetic counseling, the acquisition of ... opportunity to accelerate biological and medical research in the ... the George I. Alden Trust and a $10,000 award ... Erie Community Foundation, the Mercyhurst Biology Department has purchased ...
Cached Biology News:Final chapter to 60-year-old blood group mystery 2Final chapter to 60-year-old blood group mystery 3Researcher offers clues on the origins of life 2Researcher offers clues on the origins of life 3Mercyhurst University's new DNA sequencer to accelerate scientific research in region 2
(Date:1/14/2014)... 14, 2014 Histogen, Inc., a regenerative ... cells grown under simulated embryonic conditions, today announced that ... Suneva Medical, Inc. for physician-dispensed aesthetic products containing Histogen’s ... This agreement is an amendment to the existing license ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 EquitiesIQ, a ... Inc. (OTCQB: ALQA). Alliqua is an emerging biomedical company ... the wound care market. , Free report download: ... with a seasoned management team and Board, which launched ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, today ... In this role, Michelle will work with current and potential ... development of iLab products. Her main goal will be to ... scientific community by offering the most advanced, user-friendly, and high-impact ...
(Date:1/14/2014)... Rockville, MD (PRWEB) January 14, 2014 ... dedicated to developing innovative information technology solutions for ... other health care stakeholders, announced today the signing ... the US Food and Drug Administration (FDA). ...
Breaking Biology Technology:Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... 16 The landscape of scientific,publications strategy, planning ... guidelines. Half of global publications groups are fully,located ... a shift,to medical groups to increase clinical presentation, ... LLC., In a benchmarking study that included ...
... of international, multi-center registry presented at conference, ... BSX ) today announced that results from ... clinical utility,of the SpyGlass(R) Direct Visualization System will ... from May 17-22 in San Diego,CA. Registry results ...
... Products, L.P. Sponsors Program to Recognize Exemplary Work ... ... 16 CURE magazine announced the winner,and finalists of its ... the Oncology Nursing Society,s (ONS) 33rd Annual,Congress. Ortho Biotech Products, ...
Cached Biology Technology:Industry Executives Finding Value in Shift of Scientific Publications 2Boston Scientific's SpyGlass(R) Direct Visualization System to Be Prominently Featured at Digestive Disease Week(R) 2Boston Scientific's SpyGlass(R) Direct Visualization System to Be Prominently Featured at Digestive Disease Week(R) 3Boston Scientific's SpyGlass(R) Direct Visualization System to Be Prominently Featured at Digestive Disease Week(R) 4Boston Scientific's SpyGlass(R) Direct Visualization System to Be Prominently Featured at Digestive Disease Week(R) 5CURE Magazine Announces Winner of 2008 Extraordinary Healer Award 2
...
These 22x40mm rectangular No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 73...
... Experion software, PC, is used to ... data obtained from the Experion automated ... in electropherogram and simulated gel views ... calculations in a Results table. This ...
...
Biology Products: