Navigation Links
Immunity mechanism discovered
Date:6/18/2013

Scientists at the University of Calgary's Faculty of Medicine have discovered a mechanism that is used to protect the body from harmful bacteria. Platelets, a component of blood typically associated with clotting, were discovered to actively search for specific bacteria, and upon detection, seal it off from the rest of the body. The findings, which were published in Nature Immunology this week, provide the science community with a greater understanding of immunity.

"The science community has known that platelets do participate in immunity, but now it's been demonstrated that they have a way of actively searching for bacteria," says Craig Jenne, PhD, one of the authors of the study and a member of the university's Snyder Institute for Chronic Diseases.

The vast majority of bacteria in the blood stream is trapped by the liver in a network of specialized cells known as Kupffer cells. Once trapped, a series of immune processes take place to eradicate the bacteria; however, this can take several hours, lending time to harmful bacteria to multiply and release toxins into the neighboring cells, subsequently causing infection and cell damage and death.

"Upon entering the blood stream, bacteria can start to divide within several minutes," he says. "So if you're waiting for the immune system to deal with it, the bacteria could become an infection before it gets there."

Through imaging of the liver in animal models, scientists discovered that platelets are constantly interacting with the Kupffer cells by 'touching' them to search for captured bacteria. If nothing is detected, or if the bacteria isn't deemed particularly harmful, the platelets will move on; however, if harmful bacteria is detected, the platelets will bind to it, sealing it off from the body until the immune system can rid the bacteria altogether. This happens within seconds of cell capture and thus reduces the likelihood of infection.

"If this instantaneous response didn't exist, it could be a matter of life and death," he says.

Interestingly, it was observed that while this touch-and-go mechanism is happening continuously, platelets only appear to create this barrier around particularly harmful bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). MRSA can lead to serious and potential fatal conditions such as sepsis, and is spread through skin to skin contact.

"We now have a completely different angle of how the immune system deals with specific types of bacteria," says study author Paul Kubes, PhD, who is also director of the Snyder Institute for Chronic Diseases. "Going forth we can begin to look at how we can help our own defenses deal with these types of bacteria."


'/>"/>

Contact: Kathryn Sloniowski
kjslonio@ucalgary.ca
403-220-2232
University of Calgary
Source:Eurekalert

Related biology news :

1. Flu immunity is affected by how many viruses actually cause the infection
2. Behind closed doors: Researchers show how probiotics boost plant immunity
3. UTSW researchers identify new enzyme that acts as innate immunity sensor
4. Circuitry of cells involved in immunity, autoimmune diseases exposed
5. Pitt team finds immunity protein that ramps up inflammation, and agents that can block it
6. Innate immunity system of sheep and goat herds against viral infections clarified
7. Innate immunity
8. NIH fellowship helps researcher fight malaria, understand mosquito immunity
9. Mechanism for Burgess Shale-type preservation
10. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
11. Unexpected discovery reveals a new mechanism for how the cerebellum extracts signal from noise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
(Date:4/5/2017)... LONDON , April 4, 2017 KEY ... is anticipated to expand at a CAGR of 25.76% ... neurodegenerative diseases is the primary factor for the growth ... full report: https://www.reportbuyer.com/product/4807905/ MARKET INSIGHTS The ... of product, technology, application, and geography. The stem cell ...
(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
Breaking Biology News(10 mins):
(Date:8/18/2017)... CA (PRWEB) , ... August 18, 2017 , ... ... precision Lithography Equipment for the Semiconductor, MEMS, and Microfluidics Industries, announces the new ... and specifications found more often in automated production mask aligners. OAI has already ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... Electrospraying line of nanofiber and nanoparticle fabrication instruments from Bioinicia. ... to fully automated pilot plants and equipment for industrial manufacturing. All equipment ...
(Date:8/16/2017)... ... 16, 2017 , ... We are proud to announce the ... our Dilworth, MN site. The inspection took place Monday, July 31st through Friday, ... of a routine Bioresearch Monitoring Program (BIMO) with the USFDA wherein multiple Dermatology ...
(Date:8/15/2017)... ... August 15, 2017 , ... Kapstone Medical is ... of successes helping medical technology companies and inventors develop and safeguard their latest innovations. ... national engineering firm with a portfolio of clients in the United States and around ...
Breaking Biology Technology: