Navigation Links
Immune system protein accurate predictor of survival in pediatric septic shock
Date:8/1/2008

CINCINNATI About 4,000 children in the United States die every year from uncontrolled infections of the body known as septic shock, and researchers are pushing the boundaries of molecular science to find new therapies that can stem the condition. But a simple measure of an immune system protein within 24 hours of being admitted to the hospital for septic shock can predict survival in children, yielding a powerful tool for diagnostics and clinical trials of new septic shock therapies, according to a research team led by Cincinnati Children's Hospital Medical Center in the Aug. 1 American Journal of Respiratory and Critical Care Medicine.

The protein, interleukin-8 (IL-8), is secreted into the blood as part of the body's immune system response, the chief defense mechanism against infection-related conditions like septic shock. Previous research by the authors showed that higher blood levels of IL-8 are associated with more severe cases of pediatric septic shock and a greater chance of death. That research also pointed to the potential value of IL-8 as an early diagnostic marker of systemic bacterial infections.

The new study reports an IL-8 blood level at or below 220 pg/ml (picograms per milliliter) should allow doctors to predict with 95 percent accuracy which children with septic shock can survive through conventional antibiotics and therapies for at least 28 days following admission. Additionally, measuring IL-8 levels would make it possible to screen lower risk patients out of interventional clinical trials of experimental therapies, said Hector Wong, M.D., a physician and researcher of Critical Care Medicine at Cincinnati Children's and the study's lead author.

"Using IL-8 as a biomarker to screen low-risk septic shock patients from clinical trials of experimental or potentially high-risk therapies is an effective strategy to improve the risk-to-benefit ratio of a given intervention," said Dr. Wong, who also is professor
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Bursts of waves drive immune system soldiers toward invaders
2. Key to out-of-control immune response in lung injury found
3. Flies can turn off their immune response
4. How the plant immune system can drive the formation of new species
5. Auto immune response creates barrier to fertility; could be a step in speciation
6. Immune police recognize good and bad guys in the body
7. Agent that triggers immune response in plants is uncovered
8. Immune cells promote blood vessel formation in mouse endometriosis
9. Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
10. The PIN codes of the immune system can be hacked
11. Pathogens use previously undescribed mechanism to sabotage host immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... , Dec. 8, 2014 You,ve been here before: ... but can,t remember your password, site key or the answer ... your first grade teacher? Today, Hoyos ... app that will finally put an end to the ... 1U TM . 1U leverages a user,s smartphone to ...
(Date:12/10/2014)... DUBLIN , Dec. 08, 2014 Research ... announced the addition of the "Biometrics Market ... http://photos.prnewswire.com/prnh/20130307/600769 ... for projects such as rural banking and upgradation ... major trends witnessed in the market. Besides the ...
(Date:12/4/2014)... PALM BEACH GARDENS, Fla. , Dec. 3, ... identity management solutions, today announced that its DigitalPersona ... 4500 fingerprint readers have been deployed throughout ... Carolina , South Carolina ... network headquartered in Southern Pines, North ...
Breaking Biology News(10 mins):The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2First Bank Partners with Crossmatch to Increase Log In Security 2First Bank Partners with Crossmatch to Increase Log In Security 3
... REDWOOD CITY, Calif., Oct. 20 DigitalPersona, Inc., ... today announced that WAND Corporation, a leading supplier ... integrated DigitalPersona technology into their NextGen POS and ... use fingerprint biometrics to boost cashier accountability and ...
... Calif., Oct. 23 GenVault Corporation, the leader in ... identification, today announced that David Wellis, Ph.D., GenVault,s President ... Conference taking place on October 26th and 27th in ... will provide an overview of the company together with ...
... Scientists at the University of North Carolina at ... California, San Francisco have developed and experimentally tested a ... The researchers developed a computational method that compares ... to the naturally occurring binding partners -- known as ...
Cached Biology News:WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 2WAND Point-of-Sale Solutions Integrate U.are.U(R) Fingerprint Biometrics From DigitalPersona for Quick-Service Restaurants 3GenVault Corporation to Present at the 2009 BIOCOM Investor Conference 2Study points to new uses, unexpected side effects of already existing drugs 2
(Date:12/24/2014)... NEW YORK , Dec. 24, 2014 ... biopharmaceutical company advancing patient care in critical areas, announced ... shares of common stock, and warrants to purchase up ... an offering price of $4.00 per share and $.01 ... price of $5.00, are exercisable immediately, and expire 5 ...
(Date:12/24/2014)... December 23, 2014 GMO corn cases ... company, Syngenta, are in the process of being consolidated ... consolidated case is In Re: Syngenta AG MIR 162 ... Court for the District of Kansas. , Management of ... handed over to U.S. District Judge John W. Lungstrum.* ...
(Date:12/24/2014)... According to Ross Selinger, President of Selinger ... the national office market continues to be strong, driven by ... by the third quarter’s surprising 3.9% GDP, unemployment decreasing to ... have held inflation down and the Fed is keeping interest ... remaining soft. , This solid economic news is having a ...
(Date:12/24/2014)... December 23, 2014 Pipette.com announces their ... Twitter followers can submit their #HolidayInTheLab pictures for a ... lab mates. , For those struggling to think of ... Pipette.com Holiday in the Lab Contest provides the ideal ... followers to send pictures of their chemistree, holiday ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2
... ALPHARETTA, Ga. and MIAMI, Oct. 16 MGM Innova, ... (MACTEC) have announced a strategic alliance in carbon management ... Innova, and Allen Kibler, President of MACTEC Engineering and ... MGM Innova and MACTEC will become the leading provider ...
... at The University of Texas at Austin have conducted a ... test tube, measuring a thousandth the diameter of a human ... a high-power electron microscope was required to see the experiment. ... tube was stuffed with a thread-like crystal (a nanowire) of ...
... Life Sciences Greenhouse (PLSG), the organization providing capital ... programs to the region,s life sciences enterprises, announced ... direct company investments. , PLSG,s investment of ... family of patent-pending catheters for addressing deep vein ...
Cached Biology Technology:MACTEC and MGM Innova Announce Strategic Alliance in Carbon Management Services 2Tiny test tube experiment shows reaction of melting materials at the nano scale 2The Pittsburgh Life Sciences Greenhouse Invests $725K in Portfolio Companies 2
... member of the family of human cullin genes (CUL-1, ... S. cerevisiae cdc53 gene. Cullin-3 is proposed to be ... tight complex with cyclin E and targets it for ... E is an activator of cdk2, which leads the ...
... produces output at 470 nm; includes interface cable ... or installed into rack or desktop boxes ... is an LED that produces either pulsed or ... region -- for fluorescence measurements. The source is ...
... amber to slightly cloudy liquid. Yellow, ... per set, each containing 10 ml ... the following proportions by weight: 85% ... monooleate emulsifier), and 0.1% Mycobacterium ...
For removal of the zona pellucida. Sterile, Mouse Embryo tested...
Biology Products: