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Immune system molecule with hidden talents
Date:1/22/2013

This press release is available in German.

Dendritic cells, or DCs for short, perform a vital role for the immune system: They engulf pathogens, break them down into their component parts, and then display the pieces on their surface. This in turn signals other immune cells capable of recognizing these pieces to help kick-start their own default program for fighting off the invaders. In order to do their job, the DCs are dependent upon the support from a class of immune system molecules, which have never before been associated with dendritic cells: antibodies, best known for their role in vaccinations and diagnostics. Now, scientists at the Helmholtz Centre for Infection Research (HZI) and the Hannover Medical School (MHH) were able to show that antibodies are essential for dendritic cell maturation. The researchers' findings have been published in the renowned scientific journal, Proceedings of the National Academy of Sciences (PNAS).

The human immune system is made up of some half a dozen different cell types that are all working in tandem. Team work is key since each cell type has a single unique job to perform, which is central to its ability to help defend the body against invaders and ward off disease. If one of these players is taken out of commission, the entire system is thrown out of whack.

This is precisely what Dr. Siegfried Weiss, head of HZI Department of Molecular Immunology, and his team of researchers observed when they looked at immunodeficient mice. "Our 'RAG' mice are lacking adaptive, or acquired immunity," explains Weiss. "Basically, what this means is they are missing their antibody-producing B cells, among others."

The dendritic cells belong to a different branch of the immune system - innate immunity, which, although far less pliable, is capable of a fairly rapid response. Which is why th
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Contact: Jan Grabowski
jan.grabowski@helmholtz-hzi.de
49-531-618-11407
Helmholtz Centre for Infection Research
Source:Eurekalert  

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