Navigation Links
Immune system implicated in prematurity complication
Date:3/19/2012

ntestine of premature infants, which was surprising given the lack of these cells in the gut of newborn mice. Treg cells suppress the immune response and are critical for keeping the immune system in balance, preventing harmful inflammation.

Because of limitations related to Treg cell detection in stored tissue samples, the investigators collected fresh intestinal tissue samples from babies having surgery for NEC and for non-NEC problems, during or immediately after surgery.

Using multiple cellular "markers" and flow cytometry to identify the Treg cells, they confirmed that premature babies have an abundance of Treg cells in the intestines. Babies with NEC had about 60 percent fewer Treg cells than babies with non-NEC problems.

The investigators also detected increased expression of inflammatory cytokines (immune system signaling molecules) particularly those that suppress Treg cell development in the NEC tissue samples. And in assays of cell function, they found that the Treg cells suppressed cytokine production by and proliferation of T cells.

Follow-up studies on tissue samples from infants who had a second surgery suggest that the reduction in Treg cells is not because of an immune system defect in the babies.

"We believe that the T regulatory cells we've identified are in fact functional Treg cells and that they are down-regulated at the time of NEC," Weitkamp said. "Our studies challenge the dogma that cellular immunity is not important in the immediate neonatal period or in the pathophysiology of NEC."

Now, Weitkamp and his colleagues including neonatology fellow Joann Romano-Keeler, M.D., are studying the intestinal microbiome the collection of microbes colonizing the gut in the surgically removed samples.

"We know that the microbiome and the immune system are important in shaping each other," Weitkamp said.

"We need to understand exactly how that works and which components typically found i
'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
2. UCI-led study uncovers how Salmonella avoids the bodys immune response
3. U of Alberta researcher steps closer to understand autoimmune diseases
4. Depression could be evolutionary byproduct of immune system
5. Secrets of immune response illuminated in new study
6. Human immune cells react sensitively to stress
7. Stealthy leprosy pathogen evades critical vitamin D-dependent immune response
8. Aiding cancer therapy by mathematically modeling tumor-immune interactions
9. UCSF team uncovers how immune cells move against invaders
10. La Jolla Institute researchers identify pivotal immune cell in Type 1 diabetes in humans
11. Researchers discover novel anti-viral immune pathway in the mosquito
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... two different ways that allow unprecedented experimental insights ... of oxygen molecules in photosynthesis. The two studies ... Nature Communications . , "The new knowledge will ... oxidation, which are key components for building artificial ... energy in fuels like hydrogen, ethanol or methanol," ...
(Date:7/11/2014)... evidence has demonstrated that transplantation of mesenchymal stem cells ... or mouse models of Alzheimer,s disease (AD) and improve ... ischemia. Few studies are reported on the therapeutic effect ... AD and on the effect on oxidative injury and ... Yan and her team, School of Life Sciences, Tsinghua ...
(Date:7/11/2014)... cannabinoid receptor type 1 can inhibit voltage-gated ... reduce neurotransmitter release. However, some scholars demonstrated ... extracellular Ca2+ influx and increase neurotransmitter release. ... Hospital Affiliated to Tongji Medical College, Huazhong ... whole cell voltage-clamp and calcium imaging in ...
Breaking Biology News(10 mins):Molecular snapshots of oxygen formation in photosynthesis 2
... that nanoparticles, which are now present in everything from ... irreparably damaging effects on soil systems and the environment. ... every year, including silver nanoparticles which are popular as ... Department of Biology. "We started to wonder what the ...
... have long known that landfills produce methane, but had a ... start out as a friendly environment for the organisms that ... that one species of microbe is paving the way for ... anaerobic bacterium called Methanosarcina barkeri appears to be ...
... Scientists at the University of Hull have identified ... treating cardiovascular disease and cancer. The team ... a protein called tissue factor into endothelial microparticles, tiny ... of blood vessels. "Although tissue factor is ...
Cached Biology News:Common nanoparticles found to be highly toxic to Arctic ecosystem 2Researchers ID microbe responsible for methane from landfills 2Research identifies on-off switch for key 'factor' in heart disease and cancer 2
(Date:7/10/2014)... published today in the journal PNAS (Proceedings of ... time of day and sleep deprivation have a significant ... when looking at the best time of day to ... and for administering medicines effectively. , Researchers from the ... London, investigated the links between sleep deprivation, body clock ...
(Date:7/10/2014)... the fractional quantum Hall effect in bilayer graphene and ... tuned by an electric field. , The fractional ... to thin sheets are exposed to large magnetic fields, ... of individual electrons behave as a single system. However, ... established, many details of this collective behavior remain not ...
(Date:7/10/2014)... sit upside down forever. Nanophysics makes sure of that. Mechanics ... just published in Physical Review E . Knowledge that ... that seem to be able to sit still forever, and ... years. We will soon be able to buy smart new ... But the fact is, sooner or later the grip is ...
(Date:7/10/2014)... study by researchers at the University of Illinois ... mechanisms governing the interplay of spin and heat ... of ultrafast spintronic devices for data storage and ... as well as spin-angular momentum. In a typical ... is no spin current," explained David Cahill, a ...
Breaking Biology Technology:Time of day crucial to accurately test for diseases, new research finds 2Columbia researchers observe tunable quantum behavior in bilayer graphene 2Columbia researchers observe tunable quantum behavior in bilayer graphene 3Even geckos can lose their grip 2University of Illinois study advances limits for ultrafast nano-devices 2
... N.J., May 9, 2011 On May 17-18, ... organization created to support, mentor, and develop minority-, ... will host its fourth annual networking conference and ... at the Renaissance Newark Airport Hotel in Newark, ...
... 2011 Cell Biosciences, Inc. today announced the issuance ... and Trademark Office, Patent Nos. 7,935,489, 7,935,308 and 7,935,479. ... Biosciences, NanoPro™ Assay Technology. NanoPro assay systems utilize novel ... measurement of specific proteins in complex biological samples. These ...
... BURLINGTON, Mass., May 9, 2011 caprotec ... proprietary Capture Compound Mass Spectrometry (CCMS) platform technology for ... announced a second closing of EUR 1 million ($1.4 ... for the round to EUR 5 million ($7.2 M). ...
Cached Biology Technology:Diversity Alliance for Science to Host Fourth Annual Networking Conference and Expo 2Diversity Alliance for Science to Host Fourth Annual Networking Conference and Expo 3Diversity Alliance for Science to Host Fourth Annual Networking Conference and Expo 4caprotec bioanalytics Increases Series B Financing in Second Closing to EUR 5 Million 2
Multidrop Micro high speed 1 l bulk reagent dispenser rapidly, precisely and accurately dispenses microvolumes of 1-50 l into 384- and 96-well microplates....
...
...
Buckets for tube holder inserts...
Biology Products: