Navigation Links
Immune system implicated in prematurity complication
Date:3/19/2012

Despite advances in neonatal care, necrotizing enterocolitis (NEC) the most common gastrointestinal emergency in premature infants continues to be a deadly disease.

"We haven't made a lot of progress in identifying babies early who may be at risk for NEC, preventing it or treating it," said Jrn-Hendrik Weitkamp, M.D., a neonatologist and assistant professor of Pediatrics at Monroe Carell Jr. Children's Hospital at Vanderbilt.

Now, Weitkamp and his colleagues have discovered that disruptions in immune system regulation not previously considered to be important in NEC pathophysiology may play a role in the disease. The findings, reported in the journal Gut, suggest a new target for therapeutic interventions for NEC.

NEC is an inflammatory disease that kills intestinal tissue. Premature babies, and particularly those who have early formula feedings (breast milk has protective properties), are at increased risk for developing NEC.

About 40 percent of babies with NEC require surgery to remove dead bowel tissue and half of these babies do not survive. NEC survivors suffer long-term complications including bowel-related problems and impairments in motor and cognitive function.

Weitkamp wanted to explore whether differences in immune system regulation particularly in the "adaptive" immune response mediated by B cells and T cells might play a role in NEC. This type of cellular immunity was not considered important in the early neonatal period because it takes time to develop, and because it was not found in mouse models, Weitkamp said. But he knew from other studies that immune responses in newborn mice are not identical to immune responses in newborn humans.

Weitkamp and his colleagues turned to stored human intestinal tissue samples that had been surgically removed from preterm babies diagnosed with NEC or other intestinal diseases. They found high levels of T cells called T regulatory (Treg) cells in the i
'/>"/>

Contact: Leigh MacMillan
leigh.macmillan@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
2. UCI-led study uncovers how Salmonella avoids the bodys immune response
3. U of Alberta researcher steps closer to understand autoimmune diseases
4. Depression could be evolutionary byproduct of immune system
5. Secrets of immune response illuminated in new study
6. Human immune cells react sensitively to stress
7. Stealthy leprosy pathogen evades critical vitamin D-dependent immune response
8. Aiding cancer therapy by mathematically modeling tumor-immune interactions
9. UCSF team uncovers how immune cells move against invaders
10. La Jolla Institute researchers identify pivotal immune cell in Type 1 diabetes in humans
11. Researchers discover novel anti-viral immune pathway in the mosquito
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... for chili peppers. Information about archaeological remains of ancient ... the appearance of words for chili peppers in ancient ... and highlight the value of multi-proxy data analysis. Their ... nine papers presented in a special feature issue of ... on plant and animal domestication edited by Dolores ...
(Date:4/17/2014)... anthrax detection cartridge developed at Sandia National Laboratories and ... easier, faster and cheaper. , Bacillus anthracis ... in soils all over the world and can cause ... animals. The bacteria can survive in harsh conditions for ... may occur through skin contact, inhalation of spores or ...
(Date:4/17/2014)... ago, Katia Silvera , a postdoctoral scholar at the ... field trip in a mountainous area in central Panama when ... , Unable to identify it, they contacted German Carnevali, a ... be an unnamed species. So Carnevali recently named it after ... genus name, comprising about 40 species in the world. ...
Breaking Biology News(10 mins):Chickens to chili peppers 2Chickens to chili peppers 3Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3
... Seals shiver when exposed to cold air but not ... believe allows the diving seal to conserve oxygen and ... , The researchers presented the study at The American ... Virginia Beach, Va., October 8-11. The researchers, Arnoldus Schytte ...
... nucleolus resides deep within the cell nucleus and performs ... ribosomes, the molecular machines that convert the genetic information ... work of life. , Gary Karpen and Jamy ... Department of Energy's Lawrence Berkeley National Laboratory, have now ...
... to treating severe nerve pain ?by aiming drugs at a ... Utah scientists who study the venoms of deadly, sea-dwelling cone ... treat a chronic and debilitating form of pain suffered by ... McIntosh, a University of Utah research professor of biology, and ...
Cached Biology News:Seals protect brain, conserve oxygen by turning off shivering response on icy dives 2Seals protect brain, conserve oxygen by turning off shivering response on icy dives 3Regulating the nuclear architecture of the cell 2Regulating the nuclear architecture of the cell 3Regulating the nuclear architecture of the cell 4Regulating the nuclear architecture of the cell 5A new target for painkillers 2A new target for painkillers 3A new target for painkillers 4
(Date:1/15/2014)... (PRWEB) January 15, 2014 DTS Language ... its Online Web Portal for Life Science organizations who need ... specify the subject matter of their documents in advance with ... help reduce time-to-delivery of translations, often a critical factor in ...
(Date:1/15/2014)... 15, 2014 TaiGen Biotechnology Company, Limited ("TaiGen") today ... R-Pharm, a leading Russian pharmaceutical company, to develop and ... Russian Federation , Turkey ... is a novel antibiotic for the treatment of bacterial ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider of strategic ... business, and media events in the United States ... associate Virginia Cox , JD, is returning to the firm,s ... Cox re-joins 3D after more than two years of service ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo announced ... from the National Institutes of Health (NIH) to help ... effective treatments to patients on a faster timeline. Organovo ... Sciences (NCATS) and the National Eye Institute (NEI) to ...
Breaking Biology Technology:DTS Improves Efficiency for Life Science Document Translations 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Former FDA Associate Commissioner Returns To 3D Communications 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3
... The University of Wisconsin-Madison was one of seven U.S. ... Advanced Computing Center on Monday at the SC2004 high-power ... grant was the team led by Barton Miller , ... given to Miller and his team for their work on ...
... new book The Art of the Start: The ... Kawasaki, a managing director of Garage Technology Ventures, tells ... most entrepreneurs would be better off spending their time ... , ,This is a good message, but the delivery ...
... is over. Discounting some mutterings on the Internet, it appears ... the outcome, but rather of the process. , ,Yes, we ... and where we should be headed as a country. Yes, ... optimal integrity during the campaigning. Certainly it will take us ...
Cached Biology Technology:Scalable performance monitoring software draws grant from Intel 2Sarcasm and rainmaking advice coexist in The Art of the Start 2Sarcasm and rainmaking advice coexist in The Art of the Start 3Sarcasm and rainmaking advice coexist in The Art of the Start 4Sarcasm and rainmaking advice coexist in The Art of the Start 5Technology and democracy 2Technology and democracy 3
Monocarboxylate (lactate) transporter 2...
Chicken Anti-Human Stomatin-like 2 (STOML2 Polyclonal AntibodyNew Applications: ELISA, Western Blot...
MagSi monodispers, magnetic silica particles with modified surface for SO3 coupling chemistry....
Anti-Chicken IgY, (IgG) F(ab')2 Fragment Specific....
Biology Products: