Navigation Links
Immune system changes linked to inflammatory bowel disease revealed
Date:12/9/2010

Scientists at the Virginia Bioinformatics Institute at Virginia Tech have discovered some of the key molecular events in the immune system that contribute to inflammatory bowel disease. The results, which help researchers move one step further in their efforts to develop new drugs to treat inflammatory and immune-mediated diseases, are reported in the November 2010 edition (http://www.ncbi.nlm.nih.gov/pubmed/21068720) of the journal Mucosal Immunology from the Nature Publishing Group.

Inflammatory bowel disease starts when the gut initiates an abnormal immune response to some of the one hundred trillion or so bacteria that come into contact with the colon of the human body.

More than 1 million people are affected by inflammatory bowel disease in North America alone and direct healthcare expenses for inflammatory bowel disease in the United States are estimated at more than $15 billion annually.

Earlier mathematical and computational work (http://www.ncbi.nlm.nih.gov/pubmed/20362587) by the scientists pinpointed a special type of immune cell as a possible target for intervention strategies to fight inflammation-related disease in the gut. The immune cells identified in the earlier work, which are known as M1 or classically activated macrophages, cause inflammation and possess a specific molecule, peroxisome proliferator-activated receptor-gamma, that, when activated, favors a switch to a type of macrophage that reduces the impact of inflammation (alternatively activated macrophage or M2) . The activation of the receptor protein and the anti-inflammatory M2 macrophage switch plays a beneficial role in reducing the severity of the disease in the gut during experimentally induced inflammatory bowel disease.

"We have been able to validate experimentally some of the key events that take place in the regulati
'/>"/>

Contact: Barry Whyte
whyte@vbi.vt.edu
540-231-1767
Virginia Tech
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research scientists redefine the role of plasma cells in the immune system
2. Childrens Hospital of Philadelphia collaborates in gene therapy success in an immune disorder
3. Researchers unlock the secret of bacterias immune system
4. Immune system assassins tricks visualised for the first time
5. Penn study shows 2-sided immune cell could be harnessed to shrink tumors
6. Novel regulatory process for T cells may help explain immune system diseases
7. Shifting forms: Penn study shows how variations of same protein affect immune response
8. How immune response in pregnancy may lead to brain dysfunction in offspring
9. Studying illnesses caused by worms: Scientists are learning how immune cells communicate
10. Hormone acting as molecular glue could boost plant immune systems
11. Discovery of a cell that suppresses the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... rapidly and to an unexpected extent. The outbreak does ... the virus shows a new disease dynamic in regions, ... reason, the German National Academy of Sciences Leopoldina, acatech ... the Union of the German Academies of Sciences and ... today. , In the statement the academies call for ...
(Date:10/15/2014)... Alt will be awarded the 44th Rosenstiel Award for ... his pioneering research exploring the mechanisms of genomic instability ... cells. Alt is the second alumnus to win the ... Prize in 2003. , Alt is the Charles A. ... Harvard Medical School and an investigator at the Howard ...
(Date:10/14/2014)... published in Cancer Research shows SIRT6—a protein ... cancers—can promote the development of skin cancers by turning ... of sun-damaged skin cells. , Previously considered protective, SIRT6 ... sirtuins that help regulate genomic stability and prevent some ... repair DNA damage, which can lead to cancer. This ...
Breaking Biology News(10 mins):Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5Brandeis awards 44th Rosenstiel Award to pioneering geneticist Fred Alt 2Two-faced gene: SIRT6 prevents some cancers but promotes sun-induced skin cancer 2
... Flecknell, PhD, widely recognized for his expertise in the ... the 2009 recipient of the Charles River Laboratories, Excellence ... September 3 at the 7th World Congress on Alternatives ... Sponsored by Charles River Laboratories, in cooperation with ...
... An award-winning Los Alamos National Laboratory sound-wave ... of algae-based fuel in a cost-effective, scalable, and ... carbon footprint of biofuel production. Algae innards ... These lipids can be extracted by a relatively ...
... personalized medicine, physicians hope to provide earlier diagnoses and ... new bioinformatics study emphasizes, the first step must be ... our DNA and determine its impact on human health. ... , Dr. Sudhir Kumar led a team of researchers ...
Cached Biology News:Los Alamos technology strikes a chord with algal biofuels 2Species diversity helps ASU researchers refine analyses of human gene mutations 2Species diversity helps ASU researchers refine analyses of human gene mutations 3
(Date:10/18/2014)... (PRWEB) October 18, 2014 The Asian ... in Asia with analysis and forecast of revenue. The ... to $712.3 million by 2018, at a CAGR of ... TOC of the Asian arthroscopic devices market, to get ... provides a glimpse of the segmentation of arthroscopic devices ...
(Date:10/18/2014)... Asian Electronic Medical Record (EMR) market report defines and segments ... revenue. The electronic medical record market in the Asian region ... a CAGR of 9.4% from 2013 to 2018. , Browse ... market, to get an idea of the in-depth analysis provided. ... market in the same region, and is supported by various ...
(Date:10/18/2014)... (PRWEB) October 18, 2014 The ... Business Intelligence] - Text; Web; Speech; Machine; Video; ... Enterprise Roadmap, Market Forecasts & Analysis (2013 - ... Analytics Market into various sub segments with an ... report also identifies the factors driving this market, ...
(Date:10/17/2014)... in Alice,s journey through the looking-glass to Wonderland, mirrors ... and unexpected ways, including a new class of mirror ... today in The Optical Society,s (OSA) new high-impact journal ... the first time, a new type of mirror that ... infrared light by using an unusual magnetic property of ...
Breaking Biology Technology:The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 2The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 3The Asian arthroscopic devices market is estimated to grow to $712.3 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 2The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 3The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 4The Asian Electronic Medical Record (EMR) market is estimated to grow to $2,328.0 million by 2018 - New Report by MicroMarket Monitor 5Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 2Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 3Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 4Cloud Analytics Market (by Cloud Business Intelligence & Predictive Analytics) Expected to Cross $16.52 Billion by 2018 - New Report by MarketsandMarkets 5Magnetic mirrors enable new technologies by reflecting light in uncanny ways 2Magnetic mirrors enable new technologies by reflecting light in uncanny ways 3Magnetic mirrors enable new technologies by reflecting light in uncanny ways 4
... Wis. Berbee Information Networks Corp. caught ... the city of Cuyahoga Falls, Ohio, that allowed residents to ... technology. , ,IBM gave the Madison company its annual "Best ... to be turned on during peak periods to provide more ...
... Inc. said it has acquired insurance software from ... Wall Street, which it plans to bring in line ... submit licensing and registration filings electronically, and exam prep ... will be added to Fiserv's RegEd business unit in ...
... treat the purchase of computer systems like the purchase of ... company you are dealing with is not like your other ... and focus only on price and delivery, you may very ... very high, as failed information technology projects can even put ...
Cached Biology Technology:Six things to consider before a major software implementation 2Six things to consider before a major software implementation 3
Rabbit polyclonal to GPR56 ( Abpromise for all tested applications). entrezGeneID: 9289 SwissProtID: Q9Y653...
Annexin V Binding Buffer, 10X Concentrate Buffer , 50 ml Consult technical datasheet for details....
...
IHC Select Anti-p53, prediluted,wild & mutant, a.a. 19-26, clone DO-7 Immunogen: Human p53 Available Date: 37775...
Biology Products: