Navigation Links
Immune system changes linked to inflammatory bowel disease revealed
Date:12/9/2010

Scientists at the Virginia Bioinformatics Institute at Virginia Tech have discovered some of the key molecular events in the immune system that contribute to inflammatory bowel disease. The results, which help researchers move one step further in their efforts to develop new drugs to treat inflammatory and immune-mediated diseases, are reported in the November 2010 edition (http://www.ncbi.nlm.nih.gov/pubmed/21068720) of the journal Mucosal Immunology from the Nature Publishing Group.

Inflammatory bowel disease starts when the gut initiates an abnormal immune response to some of the one hundred trillion or so bacteria that come into contact with the colon of the human body.

More than 1 million people are affected by inflammatory bowel disease in North America alone and direct healthcare expenses for inflammatory bowel disease in the United States are estimated at more than $15 billion annually.

Earlier mathematical and computational work (http://www.ncbi.nlm.nih.gov/pubmed/20362587) by the scientists pinpointed a special type of immune cell as a possible target for intervention strategies to fight inflammation-related disease in the gut. The immune cells identified in the earlier work, which are known as M1 or classically activated macrophages, cause inflammation and possess a specific molecule, peroxisome proliferator-activated receptor-gamma, that, when activated, favors a switch to a type of macrophage that reduces the impact of inflammation (alternatively activated macrophage or M2) . The activation of the receptor protein and the anti-inflammatory M2 macrophage switch plays a beneficial role in reducing the severity of the disease in the gut during experimentally induced inflammatory bowel disease.

"We have been able to validate experimentally some of the key events that take place in the regulati
'/>"/>

Contact: Barry Whyte
whyte@vbi.vt.edu
540-231-1767
Virginia Tech
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scripps Research scientists redefine the role of plasma cells in the immune system
2. Childrens Hospital of Philadelphia collaborates in gene therapy success in an immune disorder
3. Researchers unlock the secret of bacterias immune system
4. Immune system assassins tricks visualised for the first time
5. Penn study shows 2-sided immune cell could be harnessed to shrink tumors
6. Novel regulatory process for T cells may help explain immune system diseases
7. Shifting forms: Penn study shows how variations of same protein affect immune response
8. How immune response in pregnancy may lead to brain dysfunction in offspring
9. Studying illnesses caused by worms: Scientists are learning how immune cells communicate
10. Hormone acting as molecular glue could boost plant immune systems
11. Discovery of a cell that suppresses the immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... study published in the September 2014 issue of ... Child and Adolescent Psychiatry found that children ... an increased risk of developing diabetes if they ... the nationwide Danish registers, a group of researchers ... University Hospital, Denmark, studied 48,299children and adolescents with ...
(Date:9/2/2014)... limestone is well known as a result of ... (for example, Archaeopteryx). Now, for the first time, ... equivalent of these outcrops - discoveries which include ... treader. , Despite the abundance of fossils in ... obtained from the Late Kimmeridgian equivalents of these ...
(Date:9/1/2014)... has improved steadily in recent yearsspurred in large part ... poor and disparities continue to widen among socioeconomic and ... School of Public Health (HSPH). , "The study provides ... efforts by many groups and individuals to improve U.S. ... indicates that these efforts need to be expanded," said ...
Breaking Biology News(10 mins):Risk of diabetes in children and adolescents exposed to antipsychotics 2Exceptionally well preserved insect fossils from the Rhône Valley 2Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3
... A spoonful of medicine goes down a lot easier if ... helpful for women living with HIV/AIDS and managing their chronic ... Bolton School of Nursing at Case Western Reserve University. ... managing other chronic illnesses," said Allison R. Webel, instructor of ...
... Ill. Land and marine iguanas and giant tortoises ... the Galpagos islands are more likely to harbor antibiotic-resistant ... sites on the islands, researchers report in a ... sites from free-living reptiles harbored Escherichia coli ...
... release is available in Spanish . ... because of their characteristics, produce a certain amount of social ... fact that they are subjected to moral conflicts and ethical ... very necessary from a social perspective, as in the case ...
Cached Biology News:CWRU study finds the love of a dog or cat helps women cope with HIV/AIDS 2Patterns of antibiotic-resistant bacteria found in Galapagos reptiles 2Moral imagination as a key to overcoming work-related stigmas 2
(Date:9/2/2014)... Quincy, MA (PRWEB) September 02, 2014 ... announced today the signage of a distribution agreement ... Azelis is now distributing Myriant’s bio-succinic acid in ... Kingdom and Ireland, targeting customers in the industrial ... chemical distribution powerhouse, Azelis offers a far-reaching chemical ...
(Date:9/2/2014)... Md. , Sept. 2, 2014  Synthetic ... novel anti-infective biologic and drug candidates targeting specific ... today positive results from its final preclinical toxicology ... Administration (FDA) guidance, this bridging study was required ... candidate designed to prevent the devastating effects of ...
(Date:9/2/2014)... The inventors of tinAway, a novel treatment ... seeking support for development costs through a crowdfunding campaign. ... ), was launched on September 1, 2014. , tinAway ... is based on ten years of neuroscience research. ... software engineers, Dr. Ian Dixon and Mr. Tony Burgess, ...
(Date:8/31/2014)... 2014 Available spectra is similar ... research and cultivation of a wide range of ... LEDs with proven patented and pending wide spectrum ... uniformity in critical applications in contrast to growth ... “Our customers have a large variety of differently ...
Breaking Biology Technology:Myriant and Azelis Sign European Distribution Agreement for Bio-Succinic Acid 2Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 2Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 3Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 4Synthetic Biologics to Initiate Clinical Trials of SYN-004 in 4Q 2014 to Prevent Potentially Deadly C. difficile Infections 5tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 2tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 3tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 4tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 5
... breed of pea seeds has been created that contains ... that attacks chickens. Researchers writing in the open access ... the GM seeds, and demonstrate their effectiveness in preventing ... a team of researchers from Novoplant GmbH, Germany, to ...
... , , HONG KONG, Sept. ... safe in patients who need coronary revascularization before undeferrable non-cardiac ... a paper published online in the International Journal of ... of print]). , , The paper, titled ...
... , LYNBROOK, N.Y., Sept. 11 BioSpecifics Technologies ... first in class collagenase-based products, today announced that BioSpecifics, President, ... the Biotech Industry" Conference on Wednesday, September 16, 2009, at ... Center in New York, NY. , , ...
Cached Biology Technology:OrbusNeich's Genous(TM) Bio-engineered R stent(TM) is Feasible in Patients Requiring Undeferrable Non-Cardiac Surgery, International Journal of Cardiology Publication Reports 2
ssDNA from PCR DNA in less than 1 hour. No gels, columns, or slurries. Sequence from high quality ssDNA: clearer reads, longer runs....
... Freezerworks Unlimited includes 2 clients and streamlines sample ... sharing of freezers by multiple groups without the ... Network Client/Server version for Macintosh ... with 256 colors; OS 8.6 & OS 9.x ...
Applications: Immunohistochemistry, ISH, FISH, CISH....
... Amplification Kit, 500 reactions. Prepare circular ... 4-6 h.Generate microgram quantities of template ... material.Use amplified DNA directly for cycle ... or M13 liquid cultures, colonies, plaques, ...
Biology Products: