Navigation Links
Immune system assassin's tricks visualised for the first time
Date:10/31/2010

a hole-punching machine."

The structure was revealed by combining information about a single perforin molecule visualised using the Australian Synchrotron with Professor Saibil's electron microscope images, (taken in London), of a ring of perforin molecules clustered together to form a hole in a cell membrane.

Professor Whisstock added "Now we know how it works, we can start to fine tune it to fight cancer, malaria and diabetes."

Another interesting finding is that the important parts of the perforin molecule are quite similar to those toxins deployed by bacteria such as anthrax, listeria and streptococcus, showing that this method of making holes in cell membranes is quite ancient in evolution. "The molecular structure has survived for close to two billion years, we think," said Professor Trapani.

Perforin is also the culprit when the wrong cells are marked for elimination, either in autoimmune disease conditions, such as early onset diabetes, or in tissue rejection following bone marrow transplantation. So the researchers are now investigating ways to boost perforin for more effective cancer protection and therapy for acute diseases such as cerebral malaria. And with the help of a 600K grant from the Wellcome Trust they are working on potential inhibitors to suppress perforin and counter tissue rejection.

Professor Douglas Kell, BBSRC Chief Executive said "New technologies in microscopy and synchrotron experiments have opened up tremendous opportunities for molecular biologists. This is a great example where the knowledge we gain about the normal structure and function of a molecule has the potential to underpin important developments in our health and well being."


'/>"/>

Contact: Nancy Mendoza
press.office@bbsrc.ac.uk
0044-179-341-3355
Biotechnology and Biological Sciences Research Council
Source:Eurekalert

Page: 1 2

Related biology news :

1. Penn study shows 2-sided immune cell could be harnessed to shrink tumors
2. Novel regulatory process for T cells may help explain immune system diseases
3. Shifting forms: Penn study shows how variations of same protein affect immune response
4. How immune response in pregnancy may lead to brain dysfunction in offspring
5. Studying illnesses caused by worms: Scientists are learning how immune cells communicate
6. Hormone acting as molecular glue could boost plant immune systems
7. Discovery of a cell that suppresses the immune system
8. CRISPR critters: Scientists identify key enzyme in microbial immune system
9. Microfluidic device allows collection, analysis of hard-to-handle immune cells
10. ISU researchers discover cause of immune system avoidance of certain pathogens
11. Drugs encased in nanoparticles travel to tumors on the surface of immune-system cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... that century-old museum specimens hold clues to how global climate ... and kill trees and the news is not good. ... oak and maple trees in warmer urban areas, which raises ... warming," says Dr. Elsa Youngsteadt, a research associate at NC ... , "More scale insects would be a problem, since scales ...
(Date:8/26/2014)... at Washington University in St. Louis have developed algorithms ... prone to tearing or breaking. The technology, which needs ... one day may help pinpoint minor strains and tiny ... occur. , The research is available online Aug. 27 ... , which publishes research at the nexus of the ...
(Date:8/26/2014)... a protective tent over a colony of harmful ... especially difficult. Microorganisms protected in a biofilm pose ... resistance and recalcitrance to treatment, and biofilm-protected bacteria ... infections in humans and are 50 to 1,000 ... infections. , "In essence, we may have stumbled ...
Breaking Biology News(10 mins):Museum specimens, modern cities show how an insect pest will respond to climate change 2New technology may identify tiny strains in body tissues before injuries occur 2New technology may identify tiny strains in body tissues before injuries occur 3Breakthrough antibacterial approach could resolve serious skin infections 2Breakthrough antibacterial approach could resolve serious skin infections 3
... its damaging effect on the environment and its illegal ... to adverse effects on human health, such as inflammation ... damage and possibly cancer. In a ... journal Environmental Research Letters, researchers took air ...
... pinpoint a small RNA that spurs cells to manufacture a ... Alzheimer,s disease (AD) or other types of neurodegeneration. The study ... of Cell Biology ( www.jcb.org ). Like ... in more than one version. Although scientists have identified numerous ...
... Nature a new molecular pathway used to suppress blood ... potential therapeutic value for fighting diseases of the retina and ... blood cells involved in the immune system, use this molecular ... in the same study researchers were able to reverse this ...
Cached Biology News:'E-waste pollution' a threat to human health, new research suggests 2Novel pathway regulating angiogenesis may fight retinal disease, cancers 2
(Date:8/26/2014)... 2014  ViveBio, LLC a leading provider of ... transportation, announced today that it has signed a ... of Knoxville, Tennessee to ... the United States . ViveST is the ... dried biological specimen transport systems.  The technology enables ...
(Date:8/26/2014)... (PRWEB) August 26, 2014 The global ... 8,020.1 million by 2020, according to a new study ... medicine and theranostics, and the subsequent introduction of advanced ... driving market growth over the next six years. Moreover, ... diseases such as cancer, coupled with disease triggering lifestyle ...
(Date:8/26/2014)... Trovagene, Inc. (NASDAQ:  TROV) presented data ... Assays to the Clinic with an oral ... Free Tumor DNA in Urine." In this presentation ... Cancer Monitoring (PCM) platform and results from several ... of tumor DNA mutations from urine samples of ...
(Date:8/26/2014)... YORK , Aug. 26, 2014  That,s Nice ... science markets, today announced the formation of a new ... content development. The expanded team will combine current and ... areas at That,s Nice. Guy ... Content to lead the team. Tiene was previously Director ...
Breaking Biology Technology:ViveBio and Laboratory Procurement Services Sign Agreement for Distribution of the ViveST Line of Products 2World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 2World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 3World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 4World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 5World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 6Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 2Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 3Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 4That's Nice Announces Expanded Offering For Strategic Content And Public Relations 2That's Nice Announces Expanded Offering For Strategic Content And Public Relations 3
... - Educators and software developers will have the ... learning process at the first annual Games+Learning+Society conference ... conference is being held by Games And Professional Practice ... Learning (ADL) Co-Lab and a group of instructors at ...
... Marquette University and UGS, a provider ... the largest in-kind contribution ever presented to Marquette University, in ... a market value it says is more than $30.5 million. ... Jim Factor's Geometric Modeling Lab in the Department of Mathematics, ...
... Assembly on Thursday passed AB 499, a proposed ban on ... would outlaw the cloning of embryos both for reproductive purposes ... the making of a cloned embryo for the purpose of ... were to become law would go up to ten years ...
Cached Biology Technology:Education conference to draw together games researchers 2
... the value of your microarray data using ... you need from consultation to extensive data ... methods. Utilize our expertise in combination with ... your own microarray experiments., ,Normalization and basic ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. Material: ...
BD Falcon 850 cm Smooth-surface TufRol Roller Bottle, tissue-culture treated polystyrene, blow-molded one-piece design, with easy on/off non-vented cap, packed in double bag. (20/ca) Packaging: ...
... of Flight Mass Analyzer for superior sensitivity, mass accuracy, and resolving ... m/z, * Precursor ion selection range: 150 - 4000 m/z, * ... with internal reference, * Dynamic range: 4 orders of magnitude ... ...
Biology Products: