Navigation Links
Immune-response genes affecting breast tumor eradication
Date:5/3/2012

Breast cancer patients whose tumors express high levels of genes related to immune response are more likely to have their tumor completely eradicated by pre-operative chemotherapy compared to patients with low expression of these genes, Belgian researchers report at the 4th IMPAKT Breast Cancer Conference in Brussels, Belgium.

Their research has identified a group of patients who might be good candidates for treatments with new immune-targeting therapies.

Dr Michail Ignatiadis from Institut Jules Bordet, Brussels, and colleagues analyzed gene expression data from eight studies in which patients had been treated with anthracyclines, with or without taxane chemotherapy, prior to surgery.

"We undertook this pooled analysis[1] to explore whether patients with different breast cancer subtypes respond differently to commonly used pre-operative chemotherapy, based on differences related to the cells of the tumor itself or to the non-tumor cells surrounding the tumor," Dr Ignatiadis explains.

To that end, the researchers analyzed the expression of distinct groups of genes, which they refer to as gene modules, that had been shown by other investigators to be associated with either important oncogenic pathways responsible for tumor cell proliferation or with the way the host immune system reacts to the tumor.

Patients whose tumors expressed high levels of gene modules related to immune system functions were more likely to have their tumor eradicated by the chemotherapy, they found.

"Patients with breast tumors that have high expression of genes related to immune response are more likely to present complete eradication of their tumor after the administration of commonly used pre-operative chemotherapy compared to patients with low expression of these genes. This was mainly observed in the so-called HER2-positive and less so in the ER-negative/HER2-negative and ER-positive/HER2-negative subtypes," said Dr Ignatiadis.

"The role of agents that modulate immune response in breast cancer should be studied, and in these trials patients should be optimally stratified based on their immune response," the researcher added. "Moreover, future studies should investigate whether the efficacy of anti-HER2 agents in HER2-positive early breast cancer patients is also associated with tumor immune response."

Commenting on this study, which he was not involved in, Dr Angelo Di Leo from the Hospital of Prato, Italy, former IMPAKT Chair, noted: "This study highlights the importance of the immune response of the patient as a major factor that can substantially impact treatment efficacy. It is quite clear that response to a given anti-cancer treatment may vary from one patient to another based also on the ability of the patient's immune system to aggress the tumor. This and other recently published studies pave the way to the development of a new generation of cancer drugs that can stimulate the immune response of the patient and make it more efficient in aggressing the tumor."


'/>"/>

Contact: Vanessa Pavinato
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Related biology news :

1. £2 million study to reveal workings of dementia genes
2. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
3. NIHs Genes, Environment and Health Initiative adds 6 studies
4. Scientist plans to test for blood pressure genes affected by age
5. Fishy future written in the genes
6. New tool probes function of rice genes
7. Brainy genes, not brawn, key to success on mussel beach
8. Researchers continue to find genes for type 1 diabetes
9. Genes that control cell death fingered in age-related hearing loss
10. Mapping a clan of mobile selfish genes
11. NJIT professor finds engineering technique to identify disease-causing genes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2016)... , January 22, 2016 /PRNewswire/ ... announced the addition of the  "Global ... their offering. --> http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... Research and Markets ( http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) ...
(Date:1/20/2016)... LONDON , Jan. 20, 2016 A ... positioned to directly benefit from the explosion in genomics ... from Howe Sound Research. A range of dynamic trends ... ...... - personalized medicine - pharmacogenomics - pathogen ... economies with large markets - greater understanding of the ...
(Date:1/18/2016)... JOSE, Calif. , Jan. 18, 2016 /PRNewswire/ ... security software that simplifies the use and access ... technology and go-to-market partnership with American Cyber.  ... Cyber brings extensive experience leading transformational C4ISR and ... implementing and integrating the latest proven technology solutions," ...
Breaking Biology News(10 mins):
(Date:2/10/2016)... , Feb. 10, 2016 NX Prenatal Inc., ... proprietary NeXosome® technology for early warning of adverse ... most recent study by Dr. Thomas McElrath ... Society for Maternal Fetal Medicine,s (SMFM) annual meeting held ... th , 2016.  The presentation reported initial positive ...
(Date:2/10/2016)... Inc. (NYSE MKT: ISR), a medical technology company and ... the treatment of prostate, brain, lung, head and neck ... the second quarter and six months of fiscal 2016, ... --> --> Revenue was $1.19 million ... December 31, 2015, a 12% increase compared to $1.07 ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... states, announced today the promotion of two long-standing principal investigators (PI) to the ... Medicine, Clinical Research and Development. , Dr. Laurence Chu, a Benchmark Research PI ...
(Date:2/10/2016)... Charlotte, NC (PRWEB) , ... February 10, 2016 ... ... highly anticipated expansion to their comprehensive training and support program, Sonalinkā„¢ remote monitoring. ... Sonablate® HIFU procedures performed on Friday, February 5th, connecting Dr. Samuel Peretsman to ...
Breaking Biology Technology: