Navigation Links
Immune police recognize good and bad guys in the body
Date:9/14/2007

1 diabetes, they say.

To determine what antigens Tregs can recognize, Drs. Pacholczyk and Ignatowicz did side-by-side studies of antigen receptors expressed on nave T cells and Tregs.

Here, we could quantitatively compare proportions of how many regulatory cells or how many non-regulatory cells see non-self versus self antigens, and we found these proportions to be similar,? says Dr. Ignatowicz. We found regulatory cells respond to cells presenting non-self antigens as frequently as nave T cells.

Researchers report that 70 percent of the most frequent receptors found on na ve T cells also were found on Tregs. Since receptors define what the individual T cell recognizes, it provides additional evidence that nave T cells and Tregs see the same thing, they say.

Drs. Pacholczyk and Ignatowicz reported in the August 2006 issue of Immunity that Tregs, like na ve T cells, learn what to recognize in the thymus. They also reported that most Tregs that mature in the thymus retain their regulatory properties and do not later convert to nave T cells as was previously believed. This finding emphasized the role of the thymus as the primary site where Tregs differentiate and acquire their unique inhibitory functions, they say.

Although, the majority of T cells that may harm healthy body tissue are eliminated in the thymus, some errant autoreactive cells can escape and cause autoimmune disease. Tregs previously believed to primarily recognize self-tissue with the idea of protecting it are considered the antithesis of these autoreactive cells.

It was believed that regulatory cells are baptized autoreactive cells, says Dr. Ignatowicz. They are like bad boys that went good, since they also recognize self tissue but seek to protect it.

Yet scientists kept running into the reality that some regulatory cells also were recognizing and potentially protecting invaders such as bacteria and viruses.

The MCG scienti
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Fox Chase Cancer Center scientists identify immune-system mutation
2. NYU Study Reveals How Brains Immune System Fights Viral Encephalitis
3. Genetically modified natural killer immune cells attack, kill leukemia cells
4. Studies reveal methods viruses use to sidestep immune system
5. Jumping gene helps explain immune systems abilities
6. Scientists solve structure of key protein in innate immune response
7. Rats infected as newborns grew up vulnerable to memory problems during an immune challenge
8. NYU study reveals how brains immune system fights viral encephalitis
9. Chemists identify immune system mechanism for methamphetamine binges
10. Multi-purpose protein regulates new protein synthesis and immune cell development
11. Genetically Modified Natural Killer Immune Cells Attack, Kill Leukemia Cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... study, led by researchers at the University of Warwick ... and just published in the Journal Early Human ... time spent in hospital after birth and the use ... ability in preterm children. , Mathematic abilities are crucial ... common in very preterm children. Earlier studies of children ...
(Date:9/2/2014)... issue of The FASEB Journal , ... the leading cause of blindness in adults, diabetic ... advance involves quantifying the early molecular changes caused ... Using new probes developed by scientists, they were ... diabetic retinopathy. , "My goal is to establish ...
(Date:9/2/2014)... your integrity? Tell the truth; everyone has a tipping point. ... we,ll lie if the benefit is great enough. Now, scientists ... make that decision. , The result was published online ... "We prefer to be honest, even if lying is beneficial," ... associate at the Virginia Tech Carilion Research Institute , ...
Breaking Biology News(10 mins):Mechanical ventilation a key indicator for pre-term children's math problems 2Molecular probes permit doctors to detect diabetic retinopathy before vision fails 2Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 2Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 3Scientists find possible neurobiological basis for tradeoff between honesty, self-interest 4
... recent studies that suggest the use of stored blood during ... Lung, and Blood Institute (NHLBI) funded a number of research ... and the impact of stored blood on respiratory gases. These ... concerns for oxygen delivery by transfusion are now available online ...
... group has concluded that forests and other terrestrial ecosystems in ... of the nation,s fossil fuel carbon emissions, a larger amount ... disturbance occurs. Widespread droughts, such as those that occurred ... sequestered by about 20 percent, the scientists concluded in a ...
... of a calcium carbonate crystal, a simple mollusk may have ... Daniel Speiser, a postdoctoral fellow in the Department of Ecology ... that he collected in the Florida Keys. His research of ... resulted in a study published today by Current Biology ...
Cached Biology News:Safety of stored blood among chief concerns for transfusion medicine community 2Carbon sequestration estimate in US increased -- barring a drought 2Carbon sequestration estimate in US increased -- barring a drought 3Eyes of rock let chitons see predators 2
(Date:9/2/2014)... 2014 /PRNewswire/ - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") ... consist of three large odour control systems for waste water ... "These orders are consistent with the market resurgence in ... President and CEO. "After a difficult period of restraint in ... to see sales growth. Our lower cost structure, technology improvements ...
(Date:9/1/2014)... 2014 Reportlinker.com announces that a new ... India Solid Waste Management Vehicles Market ... http://www.reportlinker.com/p02350445/India-Solid-Waste-Management-Vehicles-Market-Forecast-and-Opportunities-2019.html In India ... bodies responsible for complete handling and regulation of ... around 135,000 MT solid waste is generated daily ...
(Date:8/31/2014)... (PRWEB) August 31, 2014 ... Industry” is a professional and in-depth research ... provides basic Polyacrylamide information, including Polyacrylamide definition, ... well as industry overview. This research covers ... as well as global industry analysis covering ...
(Date:8/29/2014)... 2014 The global companion diagnostics ... 2019. It is expected to grow at a ... was valued at $1.8 billion in 2013, according ... Research. , For more information regarding analysis details ... The research report, titled “Companion Diagnostics Market (Breast ...
Breaking Biology Technology:India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 2India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 3India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 4India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 5India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 6India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 7India Solid Waste Management Vehicles Market Forecast and Opportunities, 2019 8International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 2International Polyacrylamide Industry & Copper Iodide Market Data Analysis Now Available at DeepResearchReports.com 3Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3
... April 15 Vion,Pharmaceuticals, Inc. (Nasdaq: VION ) ... and sustain compliance with The Nasdaq Capital Market,listing requirements, ... Previously, the Company announced that it had received ... Market, Inc., notifying the Company,that it does not comply ...
... Inc.,(TSX: ONC, NASDAQ: ONCY) announced that an oral ... Cancer Centre, Calgary, entitled,"Targeting Multiple Myeloma with Oncolytic ... for Cancer Research (AACR) Annual,Meeting. The meeting is ... 2008., The presentation covered preclinical work using ...
... April 15 Phytomedics Inc., an,innovative clinical ... therapeutics from natural sources, today,announced that Dr. ... company as,its President and Chief Executive Officer. ... his retirement, but who will remain on ...
Cached Biology Technology:Vion Pharmaceuticals Files Plan With Nasdaq 2Vion Pharmaceuticals Files Plan With Nasdaq 3Oncolytics Biotech Inc. Collaborators Present Reovirus Research for Multiple Myeloma at AACR Annual Meeting 2Phytomedics Inc. Appoints Dr. Laurie Smaldone Alsup, MD., as President and Chief Executive Officer 2
EDTA, disodium salt, 1 kg. Ethylene diaminetetraacetic acid.Dihydrate. Assay: 99.0-101.0%, nuclease-free.Risks: 36, 37, 38 ; Safety Precautions: 22, 36, 37. Category: Nucleotides & Enzymes & Biochemi...
Topoisomerase I, isolated from wheat germ, is an enzyme capable of removing negative supercoils from covalently closed circular DNA (1)....
The Spheroplast Kit contains qualified reagents for the preparation of yeast spheroplasts. The reagents have been optimized for use with Pichia pastoris and are guaranteed to generate 70% spheroplast...
The Proteome Profiler Human Phospho-MAPK Array Kit contains 4 membranes - each spotted in duplicate with 23 different MAPK antibodies....
Biology Products: