Navigation Links
Immune genes adapt to parasites
Date:5/25/2009

Thank parasites for making some of our immune proteins into the inflammatory defenders they are today, according to a population genetics study that will appear in the June 8 issue of the Journal of Experimental Medicine (online May 25). The study, conducted by a team of researchers in Italy, also suggests that you might blame parasites for sculpting some of those genes into risk factors for intestinal disorders.

Parasite-driven selection leaves a footprint on our DNA in the form of mutations known as "single nucleotide polymorphisms" (SNPs). Making sure that genetic variation (in the form of multiple SNPs) is maintained within certain immune genes over time helps ensure that the host can fend off different infections in different environments.

In the new study, Matteo Fumagalli and colleagues sift through 1,052 SNPs in genes that code for immune proteins called interleukins from roughly 1000 people worldwide. Of 91 genes assessed, 44 bore signatures of evolutionary selection, meaning that the genetic variation was neither due to chance nor to the migration of populations over time. And some of that variation correlated with the diversity of parasites that live alongside humans. The data suggests that having lots of different parasites around has shaped the evolution of our interleukin genes.

In general, parasitic worms appear to have had a more powerful influence on certain interleukin genes than smaller microbes such as viruses, bacteria, and fungi. That isn't surprising, says senior author Manuela Sironi, because worms typically evolve slower than bacteria or viruses, giving their human hosts time to adapt in response. Some of the genes that were shaped by worm diversity made perfect sense, as the proteins they encode help generate the precise type of immune response required to rid the body of worms.

Other genes, however, seemed to be influenced more by the diversity of viruses, bacteria, and fungi than by that of worms. SNPs in some of these genes are known risk alleles for inflammatory bowel diseases, such as Crohn's and celiac disease. These "risky" alleles were probably maintained during evolution because they promote the kind of immune response needed to fend off viruses and bacteria. But this type of response also contributes to inflammatory bowel diseases.


'/>"/>

Contact: Amy Maxmen
amaxmen@rockefeller.edu
212-327-8393
Rockefeller University Press
Source:Eurekalert

Related biology news :

1. Strong immune response to new siRNA drugs in development may cause toxic side effects
2. Genetic study confirms the immune systems role in narcolepsy
3. Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer
4. Device protects transplanted pancreatic cells from the immune system
5. Vitamin D may exacerbate autoimmune disease
6. New evidence explains poor infant immune response to certain vaccines, says MU researcher
7. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
8. A paradigm shift in immune response regulation
9. New origin found for a critical immune response
10. HIV adapts to escape immune response
11. Frogs immune system is key in fight against killer virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/16/2016)... DUBLIN , Dec 16, 2016 Research ... Access System Market - Global Forecast to 2021" report to ... ... projected to grow at a CAGR of 14.06% from 2016 to ... 2016, and is projected to reach 854.8 Million by 2021. The ...
(Date:12/15/2016)... 15, 2016 Advancements in biometrics ... wellness and wellbeing (HWW), and security of ... new passenger vehicles begin to feature fingerprint ... heart beat monitoring, brain wave monitoring, stress ... and pulse detection. These will be driven ...
(Date:12/8/2016)... , Dec. 8, 2016  Singulex, Inc., the leader ... technology, entered into a license and supply agreement with ... The agreement provides Singulex access to Thermo Scientific BRAHMS ... is used to diagnose systemic bacterial infection ... to aid in assessing the risk of ...
Breaking Biology News(10 mins):
(Date:1/18/2017)... , ... January 18, 2017 , ... ... Clinical Ops Executives 2017 in its continued commitment to the advancement of the ... to discuss current issues related to clinical trial planning and management. , ...
(Date:1/18/2017)... ... ... a new study are stating that if levels of the blood test called prostate ... is still remaining prostate cancer cells that are more likely to come back, spreading and ... indicator of whether a man’s prostate cancer is growing or not,” stated Dr. Samadi. ...
(Date:1/18/2017)... 2017 Shareholder rights law firm Johnson & ... board members of CoLucid Pharmaceuticals, Inc. (NASDAQ: ... the proposed sale of the Company to Eli Lilly ... small molecules for the acute treatment of migraines. ... signed a definitive merger agreement with Eli Lilly. Under ...
(Date:1/17/2017)... ... January 17, 2017 , ... ... Rheumatoid Factor (RF) to its VALIDATE® SP2 calibration verification / linearity test kit. ... human serum base. Each VALIDATE® SP2 kit is prepared using the CLSI recommended ...
Breaking Biology Technology: