Navigation Links
Immune genes adapt to parasites
Date:5/25/2009

Thank parasites for making some of our immune proteins into the inflammatory defenders they are today, according to a population genetics study that will appear in the June 8 issue of the Journal of Experimental Medicine (online May 25). The study, conducted by a team of researchers in Italy, also suggests that you might blame parasites for sculpting some of those genes into risk factors for intestinal disorders.

Parasite-driven selection leaves a footprint on our DNA in the form of mutations known as "single nucleotide polymorphisms" (SNPs). Making sure that genetic variation (in the form of multiple SNPs) is maintained within certain immune genes over time helps ensure that the host can fend off different infections in different environments.

In the new study, Matteo Fumagalli and colleagues sift through 1,052 SNPs in genes that code for immune proteins called interleukins from roughly 1000 people worldwide. Of 91 genes assessed, 44 bore signatures of evolutionary selection, meaning that the genetic variation was neither due to chance nor to the migration of populations over time. And some of that variation correlated with the diversity of parasites that live alongside humans. The data suggests that having lots of different parasites around has shaped the evolution of our interleukin genes.

In general, parasitic worms appear to have had a more powerful influence on certain interleukin genes than smaller microbes such as viruses, bacteria, and fungi. That isn't surprising, says senior author Manuela Sironi, because worms typically evolve slower than bacteria or viruses, giving their human hosts time to adapt in response. Some of the genes that were shaped by worm diversity made perfect sense, as the proteins they encode help generate the precise type of immune response required to rid the body of worms.

Other genes, however, seemed to be influenced more by the diversity of viruses, bacteria, and fungi than by that
'/>"/>

Contact: Amy Maxmen
amaxmen@rockefeller.edu
212-327-8393
Rockefeller University Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Strong immune response to new siRNA drugs in development may cause toxic side effects
2. Genetic study confirms the immune systems role in narcolepsy
3. Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer
4. Device protects transplanted pancreatic cells from the immune system
5. Vitamin D may exacerbate autoimmune disease
6. New evidence explains poor infant immune response to certain vaccines, says MU researcher
7. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
8. A paradigm shift in immune response regulation
9. New origin found for a critical immune response
10. HIV adapts to escape immune response
11. Frogs immune system is key in fight against killer virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... Researchers reporting in the Cell Press journal Current ... insects with rather novel sex lives. The Brazilian insects, ... genus Neotrogla , are the first example of ... reversal has been identified in several different animals, ... intromittent organ is also reversed," says Kazunori Yoshizawa from ...
(Date:4/17/2014)... is the process whereby the genetic information of ... as proteins, which have numerous different functions in ... important intermediary during gene expression, by relating the ... involved in manufacturing proteins. , By examining ... present in an organism at a given time, ...
(Date:4/17/2014)... forests are chock full of wild animals and plant ... of fungi are churning away in the soil, decomposing ... Despite the vital role these fungi play in ecological ... Stanford-led team of scientists has generated a genetic map ... America. The work was published this week in the ...
Breaking Biology News(10 mins):In sex-reversed cave insects, females have the penises 2Rapid and accurate mRNA detection in plant tissues 2Stanford biologists help solve fungal mysteries 2Stanford biologists help solve fungal mysteries 3
... depression and other mood disorders may lie in a ... inhibit other cells) shown to contribute to symptoms like ... in a new study in the Journal of ... from depression and other mood disorders often react to ...
... Bethesda, MD -- According to new research published in ... zinc levels does not directly harm the blood vessel cells. ... which then circulates in the blood and causes harmful blood ... of zinc prevent the creation of this compound, but it ...
... was right when she warned you that loud music could ... gets damaged and how. In a research report published in ... , scientists describe exactly what type of damage noise ... compound that may prevent noise-related damage. ...
Cached Biology News:Penn study: Shutting off neurons helps bullied mice overcome symptoms of depression 2Potential diagnostic marker for zinc status offers insights into the effects of zinc deficiency 2Now hear this: Scientists discover compound to prevent noise-related hearing loss 2
(Date:1/14/2014)... DIEGO and BETHESDA, Md. ... are joining together with two institutes from the National ... reliable tools for bringing safer, more effective treatments to ... the National Center for Advancing Translational Sciences (NCATS) and ...
(Date:1/14/2014)... 14, 2014 In recent years, growing ... methods in product development and promotion has led to ... mistrust, fueled by concerns about the insidious impact of ... of spectacular fines to the world’s biggest pharmas for ...
(Date:1/14/2014)... 14, 2014 Global Record Systems, ... information technology solutions for patients, physicians, the biopharmaceutical ... announced today the signing of a three-year Research ... Drug Administration (FDA). This initiative is designed ...
(Date:1/14/2014)... USA, and Cardiff, UK (PRWEB) January 13, 2014 ... technology development leader with more than 20 years in ... for optics and photonics . Hainsey will serve as ... delighted to have Dr. Hainsey join SPIE as our ...
Breaking Biology Technology:Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... a short article,published today by the Washington ... Lawrence Kogan and Russian Government lawyer Yelena,Bakulina ... US history that have,triggered new thinking in ... patent,rights and cooperative government-university-industry technology transfer,arrangements to ...
... March 21 SBT Acquisition Inc., a wholly owned,subsidiary of ... Equity IX, L.P., has successfully completed the tender offer for,all ... Inc.,(Nasdaq: LCBM ). The tender offer expired, as scheduled, ... 2008., The depositary for the offer has advised that, ...
... AMES, Iowa Iowa State University researchers are ... technologies to efficiently produce ethanol from plant biomass. ... U.S. Department of Energy recently announced theyll support ... to $944,899. The departments are awarding $18.4 million ...
Cached Biology Technology:ITSSD: Russia Can Secure Greatest Biotech Market Advances Following US, Not EU Innovation Model 2SBT Acquisition Inc. Successfully Completes Tender Offer for Shares of Lifecore Biomedical, Inc. 2SBT Acquisition Inc. Successfully Completes Tender Offer for Shares of Lifecore Biomedical, Inc. 3Iowa State researchers developing system to efficiently convert biomass to ethanol 2Iowa State researchers developing system to efficiently convert biomass to ethanol 3
... Mini-Sub cell GT cell and PowerPac basic power ... of nucleic acids in agarose gels. The Mini-Sub ... with cables and electrodes, a 7 x 7 ... casting gates, and two 1.5 mm fixed-height combs ...
... and PowerPac basic power supply are used for ... agarose gels. The mini format cell includes a ... leveling bubble. The PowerPac basic power supply, 100-120 ... 4-400 mA, and 75 W. Power cord and ...
... you reduce the chance of error. Thats ... Developed using Beckman Coulters extensive experience in ... technology, the CEQ 8000 is a fully ... fills the capillary array with a patented ...
The external laser upgrade for the Molecular Imager FX adds a 635 nm external laser; the 555 nm long pass filter is replaced with a 605 nm band pass filter to distinguish Cy5 from 532 nm excitable dy...
Biology Products: