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Immune function predicts infection risk among child trauma patients
Date:7/9/2014

y published study involves reversing the immunosuppression that follows critical injury or illness. The researchers took three blood samples in which TNF-alpha production was decreased and cultured them with GM-CSF, a drug used to stimulate white blood cell growth in bone marrow transplant patients. Once treated, the cells began to produce normal levels of TNF-alpha an indication that the immunosuppression had been reversed.

Dr. Hall is currently leading a phase IV clinical trial of GM-CSF to reverse immunosuppression in critically injured patients age 1 to 21 years old. The trial is funded by a five-year, $1.5 million grant from the National Institutes of Health and is enrolling patients in the Pediatric Intensive Care Unit at Nationwide Children's and the Surgical Intensive Care Unit at The Ohio State University Wexner Medical Center. Although findings from that project won't be ready for another year or so, the results in the Shock article seem to offer yet another weapon in physicians' arsenal when caring for critically ill and injured children, Dr. Hall says.

"We have certainly made headway in reducing preventable infections through programs such as our own Zero Hero initiative," says Dr. Hall, who also is a principal investigator in the Center for Clinical and Translational Research in The Research Institute at Nationwide Children's and an associate professor of pediatrics at The Ohio State University College of Medicine. "But what this paper suggests is that it's also important to consider the patient's immune system and how well they are able to fight off infection. We believe that critical illness- and injury-related immune suppression may be reversible with beneficial effects of clinical outcomes."


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Contact: Gina Bericchia
MediaRelations@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

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