Navigation Links
Immune function predicts infection risk among child trauma patients
Date:7/9/2014

y published study involves reversing the immunosuppression that follows critical injury or illness. The researchers took three blood samples in which TNF-alpha production was decreased and cultured them with GM-CSF, a drug used to stimulate white blood cell growth in bone marrow transplant patients. Once treated, the cells began to produce normal levels of TNF-alpha an indication that the immunosuppression had been reversed.

Dr. Hall is currently leading a phase IV clinical trial of GM-CSF to reverse immunosuppression in critically injured patients age 1 to 21 years old. The trial is funded by a five-year, $1.5 million grant from the National Institutes of Health and is enrolling patients in the Pediatric Intensive Care Unit at Nationwide Children's and the Surgical Intensive Care Unit at The Ohio State University Wexner Medical Center. Although findings from that project won't be ready for another year or so, the results in the Shock article seem to offer yet another weapon in physicians' arsenal when caring for critically ill and injured children, Dr. Hall says.

"We have certainly made headway in reducing preventable infections through programs such as our own Zero Hero initiative," says Dr. Hall, who also is a principal investigator in the Center for Clinical and Translational Research in The Research Institute at Nationwide Children's and an associate professor of pediatrics at The Ohio State University College of Medicine. "But what this paper suggests is that it's also important to consider the patient's immune system and how well they are able to fight off infection. We believe that critical illness- and injury-related immune suppression may be reversible with beneficial effects of clinical outcomes."


'/>"/>

Contact: Gina Bericchia
MediaRelations@NationwideChildrens.org
614-355-0495
Nationwide Children's Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Invisibility cloak for immune cells
2. The pig whipworm genome may aid to treat autoimmune diseases
3. Immune response affects sleep and memory -- new study
4. Gum disease bacteria selectively disarm immune system, Penn study finds
5. Faster, higher, stronger: A protein that enables powerful initial immune response
6. Marijuana shows potential in treating autoimmune disease
7. Boosting Immune process with IFN-γ helps clear lethal bacteria in cystic fibrosis
8. Zinc supplementation boosts immune system in children, Cochrane Review finds
9. How immune cells use steroids
10. Immune cells outsmart bacterial infection by dying, Penn Vet study shows
11. New experimental vaccine produces immune response against MERS virus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... This news release is available in German . ... caviar, are among the most expensive foods in the world. ... to find them. But the distinctive smell of truffles is ... and French scientists under the direction of the Goethe University ... largely produced by soil bacteria which are trapped inside truffle ...
(Date:9/30/2014)... some hope: A new research report published in October ... , explains how scientists developed a synthetic version of ... development in human and mouse eggs similar to the ... during fertilization. , "We believe that the results of ... understanding of human fertilization by providing a precise answer ...
(Date:9/30/2014)... KONG , Sept. 30, 2014 Winners of ... Economist Events, Innovation Summit scheduled to take place at the JW ... the summit, the award winners will share their experiences and the ... who have made a proven innovation over the past decade, will ... the night before the summit. It will be the first ...
Breaking Biology News(10 mins):On the trail of the truffle flavor 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 2Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 3Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 4Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 5Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 6Hear from The Economist's 2014 Innovation Award Winners at Innovation Summit on October 10th in Hong Kong 7
... a groundbreaking new gene sequencing technology, researchers have demonstrated ... in Acute Myeloid Leukemia, AML, one of the most ... by Pacific Biosciences, allows for the rapid and comprehensive ... The findings, published online April 15 in Nature ...
... There are twice as many emperor penguins in ... study released today by an international team of researchers ... an entire species from space provides an important benchmark ... population of this iconic bird. Scientists from the ...
... What can surnames tell us about the culture, genetics and ... by Chinese researchers who have traced the evolution of surnames ... Physical Anthropology , reveals how surnames can act as a ... migrations and historical events which shaped modern China. ...
Cached Biology News:Scientists identify FLT3 gene as a valid therapeutic target in acute myeloid leukemia 2Scientists complete first-ever emperor penguin count from space 2What's in a surname? New study explores what the evolution of names reveals about China 2
(Date:10/1/2014)... TeselaGen Biotechnology has received a ... their bioCAD/CAM software suite, which uses synthetic biology ... Business Innovation Research Phase II grant will be used ... from the Lawrence Berkeley National Laboratory. j5 was developed ... laboratory that develops alternative fuel technologies for the Department ...
(Date:10/1/2014)... 30, 2014 This report analyzes ... US$ Million by the following Product Segments: ... Specific end-use segments also analyzed are Pharmaceuticals ... The report provides separate comprehensive analytics for ... East, and Latin America. Annual estimates and ...
(Date:9/30/2014)... German . , The ... a semiconductor layer. Quantum dots are small structures that spontaneously ... short laser pulse is fired at the photonic crystal, its ... change in the electromagnetic field around it. This change can ... the dot. As soon as the refractive index recovers its ...
(Date:9/30/2014)... release is available in German . ... Technische Universitt Mnchen (TUM) have demonstrated a new kind ... show that future computer chips could be based on ... the main enabling technology of the semiconductor industry ... the TUM researchers and collaborators at the University of ...
Breaking Biology Technology:TeselaGen Receives $750k NSF SBIR Phase II Award 2TeselaGen Receives $750k NSF SBIR Phase II Award 3Global Specialty Enzymes Industry 2Global Specialty Enzymes Industry 3Global Specialty Enzymes Industry 4Global Specialty Enzymes Industry 5Global Specialty Enzymes Industry 6Global Specialty Enzymes Industry 7Global Specialty Enzymes Industry 8Global Specialty Enzymes Industry 9Global Specialty Enzymes Industry 10Global Specialty Enzymes Industry 11Global Specialty Enzymes Industry 12Global Specialty Enzymes Industry 13Global Specialty Enzymes Industry 14Global Specialty Enzymes Industry 15Global Specialty Enzymes Industry 16Global Specialty Enzymes Industry 17Global Specialty Enzymes Industry 18Global Specialty Enzymes Industry 19Global Specialty Enzymes Industry 20Global Specialty Enzymes Industry 21Global Specialty Enzymes Industry 22Global Specialty Enzymes Industry 23Global Specialty Enzymes Industry 24Global Specialty Enzymes Industry 25Global Specialty Enzymes Industry 26Ultrafast remote switching of light emission 2A new dimension for integrated circuits: 3-D nanomagnetic logic 2A new dimension for integrated circuits: 3-D nanomagnetic logic 3
... Metabolex, Inc., a,biopharmaceutical company focused on ... for the treatment of metabolic diseases,announced today ... company as chief,financial officer. Mr. Hill brings ... including expertise in business,development, treasury management and ...
... a ... ... TSX symbol: SBS, CALGARY, April 14 /PRNewswire-FirstCall/ - Botaneco, a wholly ... of oleosome technology in personal care,OTC and topical pharmaceutical markets, today announced ...
... April 11 /PRNewswire-FirstCall/ - YM BioSciences Inc.,(AMEX: ... company that identifies,develops and commercializes differentiated products for ... on two of its,anti-cancer drugs, nimotuzumab and tesmilifene, ... Research (AACR) Annual Meeting held from,April 12-16, 2008 ...
Cached Biology Technology:Metabolex Appoints Donald Hill as Chief Financial Officer 2Botaneco Announces Launch of Second Generation Oleosome Product 2Botaneco Announces Launch of Second Generation Oleosome Product 3YM BIOSCIENCES ANNOUNCES PRESENTATIONS FOR TWO OF ITS ANTI-CANCER DRUGS AT AACR ANNUAL MEETING 2YM BIOSCIENCES ANNOUNCES PRESENTATIONS FOR TWO OF ITS ANTI-CANCER DRUGS AT AACR ANNUAL MEETING 3
Anti-TWIK-1 Immunogen: Purified peptide from amino acids 53-69 of human TWIK-1 (Accession number O00180)....
An excellent carbonyl-reactive FRET quencher paired with Trp or Tyr. Minimum Purity: 95%. Abs(max): ~350 nm; Em(max): none. Solvent System:DMSO or DMF....
This antibody detects an ~92 kDa protein corresponding to the apparent molecular mass of the beta subunit of Hypoxia Inducible Factor-1 (HIF-1beta) on Western blots....
BI-1 Polyclonal Antibody Storage Temperature: -20C Shipping: gel pack Shelf-Life: 12 months...
Biology Products: