Navigation Links
Immune cells reveal fancy footwork
Date:12/1/2008

Our immune system plays an essential role in protecting us from diseases, but how does it do this exactly? Dutch biologist Suzanne van Helden discovered that before dendritic cells move to the lymph nodes they lose their sticky feet. This helps them to move much faster. Immature dendritic cells patrol the tissues in search of antigens. After exposure to such antigens they undergo a rigorous maturation process. During this maturation the dendritic cells migrate to the lymph nodes to activate T cells. Suzanne van Helden studied the adhesion and migration of both immature and mature dendritic cells.

Dendritic cell as a general

A dendritic cell can be compared with a pocket-sized general. As an immature cell he is on patrol in the bloodstream and in tissues in search of foreign bodies. The feet, or podosomes, help the cell to move around at a slow pace. As soon as immature dendritic cells detect a problem they must report back quickly to the T cells to warn them of impending danger. The dendritic cells are then hindered by their adhesive feet. This is the reason why at this point the cell undergoes modifications and loses its feet. In this way the mature dendritic cell can wing its way to the T cells at full speed. Once alerted, the T cells can intervene and tackle the problem in the body's infected tissues.

Van Helden not only demonstrated that dendritic cells lose their podosomes very quickly during maturation but she also identified the substances that are responsible for their disappearance. The presence of prostaglandin E2 is indispensable for this disassembly. In addition, it appears that dendritic cells lose their podosomes after interaction with certain bacteria. What is striking is that only gram-negative bacteria lead to podosome loss. Gram-positive bacteria do not have this effect. Van Helden concludes that dendritic cells can apparently distinguish between different pathogens.

Dendritic cells in action


'/>"/>
Contact: Suzanne van Helden
s.vanhelden@sanquin.nl
31-205-123-213
Netherlands Organization for Scientific Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. New type of vaccines deliver stronger and faster immune response
2. Researcher tricks immune system in diabetic mice
3. Proteomics study yields clues as to how tuberculosis might be thwarting the immune system
4. Protein tubules free avian flu virus from immune recognition
5. Lung airway cells activate vitamin D and increase immune response
6. A double-barreled immune cell approach for neuroblastoma
7. Mercury pollution causes immune damage to harbor seals
8. Seemingly suicidal stunt is normal rite of passage for immune cells
9. Scripps research team sheds light on immune system suppression
10. Response to immune protein determines pathology of multiple sclerosis
11. Genetic finding implicates innate immune system in major cause of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Sam Kean stops by Reactions this week to debunk ... that, despite what "Shark Week" may lead you to ... http://youtu.be/KhFygIoW_MA . , Kean,s book, "The Disappearing Spoon: ... History of the World from the Periodic Table of ... 10-episode video series produced for the newly launched American ...
(Date:9/2/2014)... spiky legs and their propensity for eating anything, including ... And now research from North Carolina State University finds ... across the eastern United States. , "The good news ... kind of threat to humans," says Dr. Mary Jane ... author of a paper about the research. , The ...
(Date:9/2/2014)... N.C. -- When you accidentally touch a hot oven, ... the basic neural circuits involved in sensing and responding ... the molecular players. , Duke researchers have made a ... involved in pain in worms, and have built a ... 2 in Nature Communications , may help direct ...
Breaking Biology News(10 mins):Researchers find Asian camel crickets now common in US homes 2Surprising new role for calcium in sensing pain 2Surprising new role for calcium in sensing pain 3
... of Alzheimer,s disease reports improvement in language abilities ... the research, published today in the open access ... minutes of using this new treatment. Building ... in BioMed Central,s Journal of Neuroinflammation, ...
... to be the niche. As air and water preceded life, ... cells in many tissues and provides factors necessary to keep ... cell dependents. A team of scientists at the ... assistant professor in the Laboratory of Genetics, now suggests that ...
... the burgeoning field of interventional therapies for congenital ... Vegas July 20-23 for the Pediatric & Adult ... Medical Center in Chicago will perform live cases ... On Monday, July 21st, Dr. Ziyad M. ...
Cached Biology News:Stem cell chicken and egg debate moves to unlikely arena: the testes 2Stem cell chicken and egg debate moves to unlikely arena: the testes 3Latest advances in interventional cardiology for congenital heart disease presented 2
(Date:9/2/2014)... Massachusetts , September 2, 2014 ... to BioData,s research and lab management services  ... management service, is pleased to announce the appointment of ... Culot most recently served as VP Marketing and Business ... life science research and clinical applications. Previously, ...
(Date:9/1/2014)... 01, 2014 The Collaborative R&D ... report provides comprehensive understanding and unprecedented access to ... by the worlds leading life science companies. , ... of how and why companies enter collaborative R&D ... partner’s negotiated deals terms provides critical insight into ...
(Date:8/31/2014)... Dallas, Texas (PRWEB) August 31, 2014 ... on the current state of the Epoxy Hardener ... provides a basic overview of the industry, including ... analysis and Chinese domestic market analysis are provided ... competitive landscape of the market. A comparison between ...
(Date:8/29/2014)... Albany, New York (PRWEB) August 29, 2014 ... be valued at $5.6 billion in 2019. It ... 18.1% from 2013 to 2019, and was valued ... research report published by Transparency Market Research. , ... please visit: http://www.transparencymarketresearch.com/companion-diagnostics-market.html . , The research ...
Breaking Biology Technology:Louis Culot Appointed as BioData's CEO 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 2Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 3Collaborative R&D Terms & Agreements in Pharma, Biotech and Diagnostics Industry Analysis, Size, Share, Growth, Trends And Forecast Research Report by Researchmoz.us 4Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 2Epoxy Hardener Industry Development Trends in Global & China Regions Now Available at ReportsnReports.com 3Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3
... Medarex, Inc. (Nasdaq: MEDX ) is ... at 8:30 a.m. Eastern Time on Thursday, April 30, ... for the first quarter of 2009.To access the call ... webcast can be accessed through the Investor Relations section ...
... Integrity Provider First to Bring IP Ownership into Discussion , ... ... LLC , the leading provider of data integrity solutions, announced today ... and only data integrity protection provider of its kind ...
... BioMS Medical Corp (TSX: MS), a leading developer in the ... Giese, President and CEO, will present at a session entitled ... technology sector" as part of the Alberta Economic Forum in ... Monday May 4th at 10:05am (Local time), ...
Cached Biology Technology:Medarex to Host Business and Financial Update Conference Call on Thursday, April 30, 2009 2Surety, LLC Joins Microsoft BioIT Alliance 2Surety, LLC Joins Microsoft BioIT Alliance 3BioMS Medical to present at Alberta Economic Forum in Geneva 2
... and affinity purification of small components ... monodisperse magnetic particles (2.8 m in ... surface activation is not required. Allows ... orientation for affinity purification of proteins. ...
ZO-2 (H-110)...
p-Bcl-2 (Thr 74)...
Derlin-2 (C-18)...
Biology Products: