Navigation Links
Immune cells reveal fancy footwork
Date:12/1/2008

Our immune system plays an essential role in protecting us from diseases, but how does it do this exactly? Dutch biologist Suzanne van Helden discovered that before dendritic cells move to the lymph nodes they lose their sticky feet. This helps them to move much faster. Immature dendritic cells patrol the tissues in search of antigens. After exposure to such antigens they undergo a rigorous maturation process. During this maturation the dendritic cells migrate to the lymph nodes to activate T cells. Suzanne van Helden studied the adhesion and migration of both immature and mature dendritic cells.

Dendritic cell as a general

A dendritic cell can be compared with a pocket-sized general. As an immature cell he is on patrol in the bloodstream and in tissues in search of foreign bodies. The feet, or podosomes, help the cell to move around at a slow pace. As soon as immature dendritic cells detect a problem they must report back quickly to the T cells to warn them of impending danger. The dendritic cells are then hindered by their adhesive feet. This is the reason why at this point the cell undergoes modifications and loses its feet. In this way the mature dendritic cell can wing its way to the T cells at full speed. Once alerted, the T cells can intervene and tackle the problem in the body's infected tissues.

Van Helden not only demonstrated that dendritic cells lose their podosomes very quickly during maturation but she also identified the substances that are responsible for their disappearance. The presence of prostaglandin E2 is indispensable for this disassembly. In addition, it appears that dendritic cells lose their podosomes after interaction with certain bacteria. What is striking is that only gram-negative bacteria lead to podosome loss. Gram-positive bacteria do not have this effect. Van Helden concludes that dendritic cells can apparently distinguish between different pathogens.

Dendritic cells in action

The immune system can act in different ways to keep the body healthy. Unfortunately the working of the immune system is not perfect. In cancer for example, the immune system does not respond to the altered cells that make up the tumour. It is possible that this knowledge about the adhesion and migration of dendritic cells could contribute to future developments in a new approach to cancer treatment.

Van Helden carried out her research within a group of scientists that study the function of dendritic cells in different ways. The research comprises not only fundamental research, as in Van Helden's case, but also preclinical and clinical trials. The research was made possible by a grant from NWO. Spinoza Prize winner Carl Figdor supervised Van Helden during her research.


'/>"/>

Contact: Suzanne van Helden
s.vanhelden@sanquin.nl
31-205-123-213
Netherlands Organization for Scientific Research
Source:Eurekalert

Related biology news :

1. New type of vaccines deliver stronger and faster immune response
2. Researcher tricks immune system in diabetic mice
3. Proteomics study yields clues as to how tuberculosis might be thwarting the immune system
4. Protein tubules free avian flu virus from immune recognition
5. Lung airway cells activate vitamin D and increase immune response
6. A double-barreled immune cell approach for neuroblastoma
7. Mercury pollution causes immune damage to harbor seals
8. Seemingly suicidal stunt is normal rite of passage for immune cells
9. Scripps research team sheds light on immune system suppression
10. Response to immune protein determines pathology of multiple sclerosis
11. Genetic finding implicates innate immune system in major cause of blindness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
(Date:4/5/2017)... KEY FINDINGS The global market for stem ... 25.76% during the forecast period of 2017-2025. The rise ... growth of the stem cell market. Download ... The global stem cell market is segmented on the ... cell market of the product is segmented into adult ...
(Date:4/3/2017)... 2017  Data captured by IsoCode, IsoPlexis ... a statistically significant association between the potency ... and objective response of cancer patients post-treatment. ... whether cancer patients will respond to CAR-T ... as to improve both pre-infusion potency testing and ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... , ... May 18, 2017 , ... When James Sherley, was notified earlier this year ... Valuable Brands for the Year 2017 by The Silicon Review , he was not ... good progress increasing Asymmetrex’s value, but this recognition by Silicon Valley was particularly meaningful. ...
(Date:5/16/2017)... May 16, 2017 Telehealth has long ... and something that has been kept completely separate ... But according to   Logicalis Healthcare Solutions , ... IT solutions and managed services provider ( www.us.logicalis.com ... overlooked – interrelationship between telehealth, imaging, and EHR ...
(Date:5/15/2017)... ... 2017 , ... Algenist is continuing to disrupt the skincare ... with a patented formula, clinically proven to deliver visible firming results in 10 ... to our already innovative ELEVATE product line,” said vice president of product development ...
(Date:5/11/2017)... BOTHELL, Wash. , May 11, 2017   BioLife ... developer, manufacturer and marketer of proprietary clinical grade cell and ... media ("BioLife" or the "Company"), today reported operational highlights and ... Revenue from biopreservation media product sales reached a new high ... increase of 28% over the same period in 2016. Revenue ...
Breaking Biology Technology: