Navigation Links
Immune cell 'defenders' could beat invading bacteria
Date:4/3/2014

An international team of scientists has identified the precise biochemical key that wakes up the body's immune cells and sends them into action against invading bacteria and fungi.

The patented work, published in Nature today, provides the starting point to understanding our first line of defence, and what happens when it goes wrong. It will lead to new ways of diagnosing and treating inflammatory bowel disease, peptic ulcers and even TB. It could also lead to new protective vaccines.

The discovery, the result of an international collaboration between Monash University and the Universities of Melbourne, Queensland and Cork, builds on work by Australian researchers last year who proved that a group of immune cells called MAITs, which line the gut, lungs and mouth, act as defenders against bacteria. Making up to 10 per cent of T-cells, which are essential to the immune system, mucosal-associated invariant T (MAITs) initiate the immune system's action against foreign invaders when they are exposed to vitamin B2, which is made by bacteria and fungi.

Professor Jamie Rossjohn from Monash University said that access to major facilities in Melbourne played a critical role in the research.

"To get from the first observation to today's discovery required not just smart people but access to Melbourne's Bio21 Institute platforms, dozens of visits to the Australian Synchrotron, and a global research network including our Irish colleagues who provided access to mutant bacterial strains. All that coming together allowed us to beat our international competitors and secure the patent," Professor Rossjohn said.

Professor James McCluskey, Deputy Vice-Chancellor (Research) from The University of Melbourne said little was known about the role of MAITs, beyond the fact that they had an association with bacteria. This latest research narrows down the biochemical trigger for MAIT cells to a particular group of compounds. The reaction
'/>"/>

Contact: Lucy Handford
lucyhandford@monash.edu
039-903-4815
Monash University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Newly discovered molecule may offer hope for immune disorders and runaway inflammation
2. IRCM researchers uncover a new function for an important player in the immune response
3. Study finds that fast-moving cells in the human immune system walk in a stepwise manner
4. An inventive new way to profile immune cells in blood
5. Scientists learn how pathogens hack our immune systems to go undetected
6. Study in mice raises question: Could PTSD involve immune response to stress?
7. Vitamin A used in acne medicines may help autoimmune and transplant patients
8. Puzzling question in bacterial immune system answered
9. Immune system development linked to leukemia
10. With sinus study, Saint Louis University researchers find that harmless members of microbiome spark immune reaction
11. Study: Moderate alcohol consumption boosts bodys immune system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... John and Rebecca Moores Professor of Biology and Biochemistry at ... the International Society for the Study of the Origin of ... two from the U.S., one from France and one ... elected every three years, and 36 have been named since ... countries, the ISSOL includes researchers from disciplines as varied as ...
(Date:8/20/2014)... 158 pregnant teenagers in Rochester, NY, nearly half engaged ... ice, cornstarch, vacuum dust, baby powder and soap, and ... Moreover, such teens had significantly lower iron levels as ... , Pregnant teens, regardless of pica, are at higher ... deficiency and anemia. Low iron in pregnant teens raises ...
(Date:8/20/2014)... CITY Researchers at Huntsman Cancer Institute (HCI) at the ... of the gene that encodes BCR-ABL, the unregulated enzyme ... to the American Cancer Society, nearly 6,000 new cases ... already in use, called tyrosine kinase inhibitors (TKIs), target ... do not cure CML but control it in a ...
Breaking Biology News(10 mins):UH professor named fellow by International Astrobiology Society 2Pica in pregnant teens linked to low iron 2Blueprint for next generation of chronic myeloid leukemia treatment 2
... segments of the Pacific Ocean lack sufficient iron to ... mineral stresses these microscopic ocean plants, triggering them to ... robust than it really is. , As a result, ... the researchers say, and the tropical Pacific Ocean may ...
... of diagnosed diabetes in U.S. adults age 20 and older ... to researchers at the National Institutes of Health (NIH) and ... national survey data from two periods--1988 to 1994 and 1999 ... diabetes did not change significantly over the years studied. ...
... of atmospheric ozone -- which protects Earth from the ... in the most important regions of the stratosphere above ... a new study shows. , Researchers attribute the improvement ... by the global Montreal Protocol treaty and its amendments ...
Cached Biology News:Iron critical to ocean productivity, carbon uptake 2Iron critical to ocean productivity, carbon uptake 3One-third of adults with diabetes still don't know they have it 2One-third of adults with diabetes still don't know they have it 3One-third of adults with diabetes still don't know they have it 4Atmospheric ozone recovering in mid-latitudes, report shows 2Atmospheric ozone recovering in mid-latitudes, report shows 3Atmospheric ozone recovering in mid-latitudes, report shows 4
(Date:8/18/2014)... August 19, 2014 2014 Deep ... is a professional and in-depth research report on ... Linalool information, including its definition, classification, application, ... overview. This research covers the international market analysis, ... industry analysis covering macroeconomic environment & economic situation ...
(Date:8/18/2014)... , Aug. 18, 2014 /PRNewswire/ - SQI Diagnostics Inc. ... commercializes proprietary technologies and products for advanced microarray diagnostics, ... on Friday, August 22 at 2:00 pm ET.  ... CEO, will provide a brief review of SQI,s recent ... , a diagnostics industry veteran recently appointed to the ...
(Date:8/18/2014)... , Aug. 18, 2014   Sterne, Kessler, ... firm in Washington, DC , announced ... Inter Partes Review (IPR) with the U.S. Patent ... a subsidiary of BioReference Laboratories, Inc. (Nasdaq: BRLI).  These ... or licensed by Myriad Genetics, Inc. These patents have ...
(Date:8/18/2014)... HIV Infection Drug Market and Pipeline Insight is a ... infection and the number of deaths due to AIDS has ... the globe. It has been estimated that the death rate ... with the rates for children being even much lower. A ... has been the improved access to antiretroviral drugs and therapy ...
Breaking Biology Technology:Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 2Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 3Linalool Industry & Diphenylamine Market (Global, China) 2014 Analysis Now Available at DeepResearchReports.com 4SQI Diagnostics Announces Investor Conference Call with Dr. Allan Pronovost 2SQI Diagnostics Announces Investor Conference Call with Dr. Allan Pronovost 3Sterne Kessler Files 11 IPR Petitions On Behalf Of GeneDx, Inc., Subsidiary Of BioReference Laboratories, Inc. 2Sterne Kessler Files 11 IPR Petitions On Behalf Of GeneDx, Inc., Subsidiary Of BioReference Laboratories, Inc. 3Global HIV Infection Drug Market Overview 2Global HIV Infection Drug Market Overview 3Global HIV Infection Drug Market Overview 4
... LONDON, Oct. 28 Chiltern, a leading global ... on this year,s,shortlist for the SCRIP Awards in ... be announced at the fourth annual SCRIP awards,ceremony ... Park Lane., "I am delighted that Chiltern ...
... of mammals, the protective shells of mollusks, and the needle-sharp ... wonders of nature. , Used to crush food, for structural ... and bones are composed are the strongest and most durable ... sought to mimic them. , Now, harnessing the process of ...
... Thomas Reidy, an investor in,Trinity Biotech plc (Nasdaq: ... whose American Depository Receipts are,traded on NASDAQ, will host ... to discuss the recent shareholder proposal calling for the,removal ... October 16, 2008, Mr. Reidy, and nine other shareholders, ...
Cached Biology Technology:Chiltern Is a Nominee on the SCRIP CRO of the Year Award Shortlist 2Sea urchin yields a key secret of biomineralization 2Sea urchin yields a key secret of biomineralization 3Investor Call Scheduled to Discuss Ouster Proposal of Trinity Biotech Directors 2
KNP-1 (HES1) Purified Anti-Mouse, Anti-Rat, Anti-Human, Anti-Dog, Anti-Chicken clone 35, Isotype Mouse IgG 1 , 150 µg Consult technical datasheet for details....
... E978 GenBank Accession ... Immunogen : NY-ESO-1 full-length ... ascites with 0.05% sodium ... evaluated by immunoblot on ...
NATIVE RAT OSTEOCALCIN...
Form: Ready to use Applications: Immunohistology-frozen, Immunohistology-paraffin, Western Blot, ELISA...
Biology Products: