Navigation Links
Immune cell death defects linked to autoimmune diseases
Date:1/23/2013

the absence of Bax and Bak, enough self-reactive cells survive development to persist in the body and cause autoimmune disease in organs such as the kidneys (glomerulonephritis), similar to what is seen in the most severe form of lupus.

"Our findings confirm that defective apoptosis of immune cells can cause autoimmune disease, and that Bax and Bak are important determinants of immune cell death. We were also interested to see that, in our model, loss of Bak on its own was sufficient to cause autoimmune disease, albeit to a lesser extent than losing both Bak and Bax. This supports a recent discovery that humans with mutations in the BAK gene are predisposed to certain autoimmune diseases."

The research provides hope for people with autoimmune diseases as Bax and Bak activity can be triggered by a new class of potential anti-cancer agents, called BH3-mimetics, which are currently in clinical trials for certain types of leukaemia in Melbourne, Dr O'Reilly said. "Our findings suggest that BH3-mimetics might be an exciting new option for treatment for autoimmune conditions, by activating Bax and Bak and making the self-reactive immune cells which are causing the autoimmune disease to die," she said.


'/>"/>

Contact: Vanessa Solomon
solomon@wehi.edu.au
61-393-452-971
Walter and Eliza Hall Institute
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Immune system molecule with hidden talents
2. Protein structure: Immune system foiled by a hairpin
3. La Jolla Institute identifies molecular switch enabling immune cells to better fight disease
4. Loneliness, like chronic stress, taxes the immune system
5. Smile: Gingivitis bacteria manipulate your immune system so they can thrive in your gums
6. New insights into how immune system fights atherosclerosis
7. Alzheimers disease: Cutting off immune response promises new approach to therapy
8. New technique could make cell-based immune therapies for cancer safer and more effective
9. Engineered immune cells produce complete response in child with an aggressive pediatric leukemia
10. Steroid hormone receptor prefers working alone to shut off immune system genes
11. Combining two genome analysis approaches supports immune system contribution to autism
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Immune cell death defects linked to autoimmune diseases
(Date:4/17/2014)... and pathogens that devastate honeybees in Europe, Asia and ... do not appear to be impacting native honeybee populations ... researchers., The invasive pests include including Nosema microsporidia ... honeybees appear to be resilient to these invasive pests, ... control pests in Europe, Asia and the United States ...
(Date:4/17/2014)... implicated in many serious conditions such as heart disease, ... for drug therapies. Unfortunately, there is still much scientists ... provides fresh and unexpected insight into the structure of ... β-subunit molecules - which are responsible for ,fine-tuning, the ... the most recent edition of the Journal of ...
(Date:4/17/2014)... -- Indiana University researchers have detected new early-warning signs ... This discovery could have far-reaching implications for the diagnosis ... of over 25 million Americans. , "We had not ... at such early stages," said Ann Elsner, professor and ... lead author of the study. "We set out to ...
Breaking Biology News(10 mins):East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3Structure of sodium channels different than previously believed 2New technique detects microscopic diabetes-related eye damage 2New technique detects microscopic diabetes-related eye damage 3
... pro-inflammatory signaling molecule involved in immune response in ... are doing" in creating drugs based on a ... Oct. 1 issue of the Journal of Immunology, ... unveiled the crystal structure of mouse interleukin-1 receptor-associated ...
... , The annual Educational Technology Award of the ... the project 'Virtual microscopy as a teaching aid' of ... awarded project utilizes advanced digital imaging and network technology ... internet. , 'Virtual specimens' incorporated into educational applications ...
... into the evolutionary process by examining how albinism ... University Biology Professor Richard Borowsky, examined two populations ... both populations was linked to Oca2--a pigmentation gene ... albinism in humans. They observed different deletions in ...
Cached Biology News:Molecular research suggest shift needed in how some drugs are created 2Genetic analysis of cavefish reveals more about evolution 2
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched Sound ... Patients listen to sound therapy that is tailor-made for ... to months, their tinnitus volume decreases. , AudioNotch has previously ... Notched White Noise. Now, AudioNotch is pleased to announce to ...
(Date:1/14/2014)... Communications, a leading provider of strategic communications services to corporations and ... the United States and Europe ... JD, is returning to the firm,s Washington, D.C. ... more than two years of service as Associate Commissioner for the ...
(Date:1/14/2014)... 14, 2014 iLab Solutions, the leader in ... new Director of Product Strategy. In this role, Michelle will ... sub-teams to guide in the development of iLab products. Her ... maximum possible benefit to the scientific community by offering the ...
(Date:1/14/2014)... USA, and Cardiff, UK (PRWEB) January 13, 2014 ... technology development leader with more than 20 years in ... for optics and photonics . Hainsey will serve as ... delighted to have Dr. Hainsey join SPIE as our ...
Breaking Biology Technology:Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... MOUNTAIN VIEW, Calif., Feb. 17 Frost & Sullivan, ... is,regaining its strength, thanks in part to an unprecedented ... additional stimulus packages from,foreign governments. , ... "President Obama,s stimulus package is clearly serving ...
... Warwick have found that tiny nanoparticles could be twice ... non mixing liquids than previously believed. This opens ... of nanoparticles in living cells, polymer composites, and ... working on ways of further artificially enhancing this new ...
... LLC, a wholly owned subsidiary of The Dow Chemical ... Rice Research Institute (CNRRI) of Hangzhou,China, announced today that ... strengths of Dow AgroSciences, platform of traits and technologies,with ... "We look forward to working with CNRRI to introduce ...
Cached Biology Technology:Frost & Sullivan Forecasts Early Rebound: Strong Growth Ahead for Global Economy 2Nanoparticles double their chances of getting into sticky situations 2Dow AgroSciences, China National Rice Research Institute Announce Collaboration on Rice Research 2
Activating Agents, 7-azabenzotriazol-1-yloxy-tris-(pyrrolidino)phosphonium hexafluorophosphate...
... Immunogen: Fusion protein derived from ... ASIP/PAR-3 (atypical PKC isotype-specific interacting protein/ ... not related to the protease-activated-receptors also ... Xenopus (positive controls: Caco-2 MDCK A6 ...
...
Request Info...
Biology Products: