Navigation Links
Immune-boosting colorectal cancer drug shows promise
Date:7/3/2013

Lugano-Barcelona-- New data on an emerging treatment that aims to fight colorectal cancer by stimulating the immune system have been presented at the ESMO 15th World Congress on Gastrointestinal Cancer.

The findings confirm the biological action of the drug called MGN1703 and suggest it may be possible to identify which gastrointestinal cancer patients will benefit most from the treatment, reported Prof Hans-Joachim Schmoll from Martin Luther University, Halle, Germany.

MGN1703 is a small DNA molecule recognised by a receptor --called toll-like receptor 9-- that is expressed in certain immune system cells. The drug is designed to broadly activate all components of the innate immune system to stimulate the destruction of cancer cells.

The new data come from the final analysis of the phase II IMPACT study, which investigated MGN1703 in 59 patients with metastatic colorectal cancer.

The IMPACT study was an international, randomised, double-blind trial that was conducted in patients who had achieved disease control after 4.5 to 6 months of chemotherapy.

Standard chemotherapy for patients with metastatic colorectal cancer who respond to treatment is often completely or partially discontinued until the disease progresses. It was during this 'maintenance' phase of treatment that the new drug was administered.

Prof Schmoll and colleagues had intended to test the drug on 129 patients, but difficulties recruiting participants meant the trial was closed after 59 patients had been randomly assigned to either MGN1703 (43 patients) or placebo (16 patients).

"After a median follow-up of 17.3 months, MGN1703 prolonged profession-free survival from the start of induction as well as start of maintenance therapy, including four patients with sustained progression-free survival who are still on treatment," Prof Schmoll says.

A pre-planned analysis of immune cell populations showed that the activation of a pa
'/>"/>

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biomarker identification may lead to new noninvasive test for colorectal cancer detection
2. New gut microbiome research to explore red meat -- colorectal cancer pathway
3. Signalling pathways meeting targeting the HER/EGFR family: Focus on breast, lung and colorectal cancers
4. Study shows that diet of resistant starch helps the body resist colorectal cancer
5. 3 new genetic links to colorectal cancer
6. Eliza Corporation and BlueCross BlueShield of South Carolina Drive Awareness and Healthier Behavior to Increase Colorectal Cancer Screenings by 45 Percent
7. How cancer spreads: Metastatic tumor a hybrid of cancer cell and white blood cell
8. Hijacking stress response in cancer
9. Damon Runyon Cancer Research Foundation awards $3.6 M to 9 top young clinical investigators
10. ACRG and BGI report new evidence for the genetic bases of liver cancer
11. Cancer is a result of a default cellular safe mode, physicist proposes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Fla. , Aug. 21, 2014 /PRNewswire-iReach/ ... that it has agreed to a partnership ... Orlando,s fastest growing Certified Nursing ... Gabriel Health Institute  an exclusive member of ... result, Binary Biometrics will improve its service ...
(Date:8/21/2014)... -- Nine researchers from Beth Israel Deaconess ... in "The World,s Most Influential Scientific Minds 2014," ... Thomson Reuters ScienceWatch, a web resource for science metrics ... recognized as among the most influential "are performing and ... the advancement of their science," according to a Thomson ...
(Date:8/21/2014)... Mller the Fram Strait is a key region in the ... between Greenland and Svalbard warm Atlantic water flows to the ... cold Arctic water masses and sea ice push their way ... portion of the Atlantic water cools here on its way ... of the water caused in this manner drives the global ...
Breaking Biology News(10 mins):LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 2LiveScan Provider Binary Biometrics Announces Partnership with Preeminent CNA School, Gabriel Health Institute to Expand Services in Orlando Region 3BIDMC researchers named among 'the most influential scientific minds' 2BIDMC researchers named among 'the most influential scientific minds' 3Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3
... techniques of computer engineering to a mechanistic diagram describing ... of researchers in Switzerland has been able to tease ... the crucial cross-talk between cellular signaling pathways takes place ... The novel in silico model is described in a ...
... Cancer Institute have shown in a laboratory study that ... the damage caused by a form of muscular dystrophy. ... and Development, the researchers demonstrated that manipulating a genetic ... mice with Duchenne muscular dystrophy, slowing the disease-associated muscle ...
... new vaccine delivery system using microspheres of a biodegradable polymer ... some cases, but also appears to stimulate an immune response ... University report their findings today at the ASM Biodefense and ... producing antibodies that block entry into the cell. In ...
Cached Biology News:Executable biology -- Computer science sheds light on animal development 2Switching genes to overdrive improves muscular dystrophy symptoms in mice 2Biodegradable microspheres deliver time release vaccines, stimulate different immune response 2
(Date:8/22/2014)... DUBLIN , Aug. 22, 2014 ... the "Global and China Gel Permeation Chromatography (GPC) ... The Global and China Gel Permeation Chromatography ... on the current state of the global gel permeation ... The report provides a basic overview of the ...
(Date:8/22/2014)... Nerium International, the go-to, buzzworthy ... spotlight again. Nerium will showcase its signature NeriumAD® ... Contouring Cream to Hollywood’s elite at the official ... 66th Primetime Emmy® Awards. , Developed from cutting-edge ... trials show that NeriumAD night cream dramatically reduces ...
(Date:8/21/2014)... Aug. 21, 2014  BioSpecifics Technologies Corp. (NASDAQ: ... first in class collagenase-based products marketed as XIAFLEX ... the U.S. and XIAPEX ® in the ... a randomized, double-blind Phase 2a study of CCH ... fibrosclerotic panniculopathy. The results showed that all three ...
(Date:8/21/2014)... An international research team including DESY scientists has observed ... The team reports in the journal Science ... lattices inside the nanodroplets. It is the first time ... in larger samples of what is known as superfluid ... exceeded our best expectations," says Andrey Vilesov of the ...
Breaking Biology Technology:Global and China Gel Permeation Chromatography (GPC) Industry Report 2014 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 2Nerium International Joins Television’s Biggest Stars at Backstage Creations Giving Suite at the 66th Primetime Emmy Awards 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 2BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 3BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 4BioSpecifics Technologies Corp. Announces Positive Data from Phase 2a Study of CCH for Treatment of Cellulite 5Scientists observe quantum vortices in cold helium droplets 2
... World Asia 2009, scheduled 16-17 February in Kuala ... top Jatropha decision makers have been scheduled. Kicking ... was held with Pradip Bhar, Chief Executive Officer ... Offered by free download, this informative interview lends ...
... (Nasdaq: SGMO ) announced today that Edward ... the progress of Sangamo,s ZFP Therapeutic,development programs and an ... on Monday, January 12, 2009 at the J.P. Morgan ... The presentation will be webcast live and may be ...
... Dobzhansky, the late great geneticist and evolutionary biologist, said ... the light of evolution."This year marks the 200th birthday ... anniversary of the publication of the Origin of ... by means of natural selection in exquisite detail. Universities, ...
Cached Biology Technology:Jatropha World 2009 Advance Access: Surprisingly Candid Interview Series Examines Biofuel Predictions Compared to Fossil Fuels 2Jatropha World 2009 Advance Access: Surprisingly Candid Interview Series Examines Biofuel Predictions Compared to Fossil Fuels 3Jatropha World 2009 Advance Access: Surprisingly Candid Interview Series Examines Biofuel Predictions Compared to Fossil Fuels 4Sangamo BioSciences to Present at the 27th Annual J.P. Morgan Healthcare Conference 2GEN Joins Charles Darwin 2009 Celebration 2
... an automated hybridization system for the processing ... the hybridization and post hybridization washing of ... instrument can process up to 12 slides ... multi-protocol software, enabling the user to run ...
... (GST) is commonly used as a fusion ... (1). The GSTTag sequence has been reported ... cases the solubility of its fusion partners. ... form, GSTTag fusion proteins can be purified ...
... the biological data hidden in your samples with ... allows you to create your own microarray designs ... your own pace and receive delivery of your ... is a secure, online array creation application tool ...
Acetylcholinesterase (human brain, AChE)...
Biology Products: