Navigation Links
Immune-boosting colorectal cancer drug shows promise
Date:7/3/2013

Lugano-Barcelona-- New data on an emerging treatment that aims to fight colorectal cancer by stimulating the immune system have been presented at the ESMO 15th World Congress on Gastrointestinal Cancer.

The findings confirm the biological action of the drug called MGN1703 and suggest it may be possible to identify which gastrointestinal cancer patients will benefit most from the treatment, reported Prof Hans-Joachim Schmoll from Martin Luther University, Halle, Germany.

MGN1703 is a small DNA molecule recognised by a receptor --called toll-like receptor 9-- that is expressed in certain immune system cells. The drug is designed to broadly activate all components of the innate immune system to stimulate the destruction of cancer cells.

The new data come from the final analysis of the phase II IMPACT study, which investigated MGN1703 in 59 patients with metastatic colorectal cancer.

The IMPACT study was an international, randomised, double-blind trial that was conducted in patients who had achieved disease control after 4.5 to 6 months of chemotherapy.

Standard chemotherapy for patients with metastatic colorectal cancer who respond to treatment is often completely or partially discontinued until the disease progresses. It was during this 'maintenance' phase of treatment that the new drug was administered.

Prof Schmoll and colleagues had intended to test the drug on 129 patients, but difficulties recruiting participants meant the trial was closed after 59 patients had been randomly assigned to either MGN1703 (43 patients) or placebo (16 patients).

"After a median follow-up of 17.3 months, MGN1703 prolonged profession-free survival from the start of induction as well as start of maintenance therapy, including four patients with sustained progression-free survival who are still on treatment," Prof Schmoll says.

A pre-planned analysis of immune cell populations showed that the activation of a pa
'/>"/>

Contact: ESMO Press Office
media@esmo.org
European Society for Medical Oncology
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biomarker identification may lead to new noninvasive test for colorectal cancer detection
2. New gut microbiome research to explore red meat -- colorectal cancer pathway
3. Signalling pathways meeting targeting the HER/EGFR family: Focus on breast, lung and colorectal cancers
4. Study shows that diet of resistant starch helps the body resist colorectal cancer
5. 3 new genetic links to colorectal cancer
6. Eliza Corporation and BlueCross BlueShield of South Carolina Drive Awareness and Healthier Behavior to Increase Colorectal Cancer Screenings by 45 Percent
7. How cancer spreads: Metastatic tumor a hybrid of cancer cell and white blood cell
8. Hijacking stress response in cancer
9. Damon Runyon Cancer Research Foundation awards $3.6 M to 9 top young clinical investigators
10. ACRG and BGI report new evidence for the genetic bases of liver cancer
11. Cancer is a result of a default cellular safe mode, physicist proposes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... , Dec. 09, 2014 Research and ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has ... in India 2015-2019" report to their offering. ... this market is the adoption of multimodal biometric ... characteristic of an individual for verification and identification ...
(Date:12/10/2014)... N.C. , Dec. 9, 2014  Wake Forest Baptist ... education building for its School of Medicine. Funding for ... larger capital campaign that will be publicly launched next ... be located in the former 60 series R.J. Reynolds ... Innovation Quarter. Construction will begin immediately with plans to ...
(Date:12/5/2014)... 4, 2014  Tute Genomics, a leader in cloud-based ... Series A1 funding led by UK-based Eurovestech. Peak Ventures ... the investment round. "We are at a ... next-generation sequencing and seeks new approaches for the diagnosis, ... , MD MBA, and CEO of Tute Genomics. "One ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3
... ozone as something in the upper atmosphere that protects ... level, however, ozone is a pollutant that damages crops, ... associate professor of crop sciences and USDA Agricultural Research ... threshold for damage is critical to understanding the current ...
... from a few tropical places in Asia, Africa, South and ... lighter build, thinner bodies and longer legs, better suited for ... of their legs, allowing them to better climb different surfaces, ... core area is the Amazon, from where most of the ...
... PROVIDENCE, R.I. [Brown University] Researchers from Brown University have ... can cause argyria, a rare condition in which patients, skin ... first conceptual model giving the whole picture of how one ... Brown and part of the research team. "What,s interesting here ...
Cached Biology News:Ozone's impact on soybean yield: Reducing future losses 2Ozone's impact on soybean yield: Reducing future losses 39 colorful and endangered tree-dwelling tarantulas discovered in Brazil 2How silver turns people blue 2How silver turns people blue 3
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... series is designed to introduce cutting edge ... users and partners of platform upgrades. This ... benefits; empowering users in their quest to ... tools. , According to SoundConnect’s Marketing Manager, ...
(Date:12/24/2014)... 23, 2014 According to Ross Selinger, President ... of ITRA Global, the national office market continues to be ... This is evidenced by the third quarter’s surprising 3.9% GDP, ... Low energy costs have held inflation down and the Fed ... the housing market remaining soft. , This solid economic news ...
(Date:12/24/2014)... 23, 2014 Nashville Fertility Center announced ... treasurer for the American Society for Reproductive Medicine (ASRM), ... research in reproductive medicine. In his new role ... the executive board and will have a voice in ... has actively supported ASRM since 1984 when he joined ...
(Date:12/24/2014)... Diego, CA (PRWEB) December 23, 2014 ... where their Twitter followers can submit their #HolidayInTheLab ... themselves and their lab mates. , For those struggling ... lab mates, the Pipette.com Holiday in the Lab Contest ... Pipette.com Twitter followers to send pictures of ...
Breaking Biology Technology:SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3ITRA Global Reports Long Island Is Out of Sync With The National Office Market 2ITRA Global Reports Long Island Is Out of Sync With The National Office Market 3Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 2Nashville Fertility Center Announces Dr. George A. Hill Selected to Serve as ASRM Treasurer for 2014-15 3Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2
... of a new way to tune and enhance thermal conductivity ... a given material gives engineers a new tool for ... a number of other powered devices. The finding was ... associate professor of mechanical engineering at Vanderbilt University, and published ...
... 14, 2011 /PRNewswire-Asia/ -- ShangPharma Corporation (NYSE: ... pharmaceutical and biotechnology research and development outsourcing company, today ... Annual Healthcare Conference, to be held in San Francisco ... Hui, founder and Chief Executive Officer of ShangPharma, and ...
... Elsevier, a world-leading provider of scientific, technical and medical ... Societies (FEBS) announced today the launch of FEBS ... is dedicated to publishing articles across the molecular and ... ,In launching this new journal, FEBS and Elsevier serve ...
Cached Biology Technology:New method for enhancing thermal conductivity could cool computer chips, lasers and other devices 2New method for enhancing thermal conductivity could cool computer chips, lasers and other devices 3Elsevier and Federation of Biochemical Societies Launch New Journal: FEBS Open Bio 2Elsevier and Federation of Biochemical Societies Launch New Journal: FEBS Open Bio 3
... EtBr Spin Columns provide a rapid and simple ... (100 bp to 10 kb) from stained agarose ... is excised from an agarose gel and loaded ... of the column are a series of membranes ...
... Kit enables efficient extraction of DNA fragments from 150 ... gels. The procedure uses GelMelt solution to dissolve the ... a silica membrane in a spin column format. After ... low-salt buffer. Each spin column can bind up to ...
When added to either StemSep CD4+ or CD8+ T Cell Enrichment cocktails, human HLA-DR TAC is designed to deplete human HLA-DR from samples to isolate resting CD4+ or CD8+ T cells....
... This microscope is described by end-users ... it incorporates the fundamentals of light microscopy ... and small footprint, it does not require ... in a busy lab environment. The DM-BA300 ...
Biology Products: