Navigation Links
Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway
Date:7/24/2008

ation of OGF or knockdown of OGFr by siRNA technology eliminated the inhibitory effects of imidazoquinolines on cell replication. "Thus our data," Dr. Zagon said, "brings a paradigm shift to our thinking about a drug widely used in the clinics. Rather than imiquimod activity being mediated by induction of various cytokines, including interferon (IFN)-α, IFN-γ, tumor necrosis factor-α (TNFα) interleukin (IL)-1α, and IL-12 as currently thought, an entirely new pathway - native to body chemistry - has been discovered to regulate cell proliferation by imidazoquinolines." Co-author, Moshe Rogosnitzky adds: "The elucidation of imiquimod's immune-independent mechanism of action in cancer also creates exciting new therapeutic possibilities for a number of non-cancer conditions, and these are now being further explored. Such studies could lead to new off-label applications for imiquimod as well as development of imiquimod analogues and unique combination therapies." Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine stated "Through decades of elegant and ground-breaking work, Zagon and colleagues have identified the role of met-enkephalin (the opioid growth factor OGF) and the OGF receptor in regulating cell proliferation. The current study demonstrates that the mechanism of imidazoquinoline activity is via OGF and OGFr which will have a profound impact on its use as a therapeutic for cancer and many other non-cancerous disorders."


'/>"/>

Contact: Dr. Ian S. Zagon
isz1@psu.edu
717-531-8650
Society for Experimental Biology and Medicine
Source:Eurekalert

112

GOOD

Page: 1 2

Related biology news :

1. Viral recombination another way HIV fools the immune system
2. Video released of rapid Alzheimers improvement after new immune-based treatment
3. Researchers hack final part of the immune system code
4. Control switches found for immune cells that fight cancer, viral infection
5. A single mechanism for hypertension, insulin resistance and immune suppression
6. Pitt receives $2.5 million to simulate and analyze brain, immune system activity
7. New findings on immune system in amphibians
8. UCLA researchers develop new PET scanning probe that will allowing monitoring of the immune system
9. Retraining immune cells to kill tumors
10. Sugar linkage could lead to better treatment for autoimmune diseases
11. Effective cancer immune therapy through order in the blood vessels
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/10/2014)... pods began appearing on U.S. store shelves in early ... ever since. The small packets can be tossed into ... a liquid or powder. The convenience, though, has come ... from researchers at Nationwide Children,s Hospital found that from ... of 17,230 children younger than 6 years of age ...
(Date:11/6/2014)... -- A groundbreaking paper from a team of Florida ... of how plants could adapt to and survive environmental ... published in the latest issue of the journal ... (the complex of DNA and proteins) is organized in ... that some genes are turned on and others are ...
(Date:11/5/2014)... biology in the UTSA College of Sciences, is ... to receive a two-year $300,00 National Science Foundation ... The funding supports President Obama,s BRAIN Initiative, a ... technology that will demystify complex brain processes. ... are broken into the interactions of multiple components, ...
Breaking Biology News(10 mins):Study finds laundry detergent pods, serious poisoning risk for children 2Maize analysis yields whole new world of genetic science 2UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
... 6th Meeting of the European Society of Oncological ... from 16 to 18 January 2009, with organisers ... onco-urology specialists. With the fast-changing developments in ... urologists, gynaecologists, oncologists, scientists and researchers the opportunity ...
... Park Ridge, Ill. (December 16, 2008) A study recently ... that eating one egg per day is responsible for less ... (CHD) in healthy adults. Alternatively, lifestyle factors including poor diet, ... of heart disease risk, depending on gender. This study adds ...
... Physiological Society of Japan (PSJ) has chosen Springer to ... Sciences , starting in January 2009 with Volume 59, ... by Society and Medical Tribune Co. Ltd. The ... which includes such publications as Experimental Brain Research ...
Cached Biology News:6th ESOU Meeting 2New study 'pardons' the misunderstood egg 2New study 'pardons' the misunderstood egg 3Springer and the Physiological Society of Japan sign publishing agreement 2
(Date:11/21/2014)... , Nov. 21, 2014   TRU-D SmartUVC LLC ... their superbug-killing UVC automated disinfection robot, TRU-D SmartUVC, at FIS ... from Nov. 23 to 26 at Stand 23. ... United Kingdom,s largest infection-related event of ... societies to one of the leading events of its type ...
(Date:11/21/2014)... (PRWEB) November 20, 2014 Author Matthew ... Walk to the Other Side” published as a ... Finalist in the “Fiction: Short Story” category of the ... Keen, President and CEO of USA Book News, said ... and independent publishers, including Simon & Schuster, Penguin, John ...
(Date:11/21/2014)... NY (PRWEB) November 20, 2014 The ... now available as an open access journal featuring the ... infrared fluorescent proteins to preserve photoresponsiveness in the retina ... Two-color fluorescent in situ hybridization using chromogenic substrates in ... for DNA, RNA, and protein electrophoresis , ...
(Date:11/21/2014)... November 21, 2014 2014 Deep ... Industry” is a professional and in-depth research report ... ferrocyanide information, like its definition, classification, application, ... overview. This report covers the international market analysis, ... (such as the US, Europe, Asia, China, Japan ...
Breaking Biology Technology:TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 2TRU-D SmartUVC to Showcase Superbug-Killing Robot at FIS 2014 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3
... hiring laboratory reagent and diagnostics industry veteran , ... ... a high-tech provider of rapid prototyping and manufacturing services for ... of Operations. Dr. Anderson brings years of entrepreneurial and business ...
... SALVAT announced today the,submission of the response ... Otic Solution in Single Dose Containers). In an,Approvable ... requested additional,data with respect to chemistry, manufacturing, and ... classify the complete response as a Class 2,resubmission, ...
... Calif., Nov. 5 Onyx,Pharmaceuticals, Inc. (Nasdaq: ... the 2008 Credit Suisse Health Care Conference on ... a.m. Pacific Time). Interested parties,may access a live ... http://www.onyx-pharm.com/wt/page/event_calendar , It is recommended that listeners ...
Cached Biology Technology:ALine, Inc. Expands Management, Adding Roger Anderson, Ph.D., as VP of Operations 2SALVAT Announces Submission of Complete Response to FDA Approvable Letter for CETRAXAL(R) 2
HOXC11 Antibody...
PPOX Immunogen: PPOX (AAH02357, 378 a.a. ~ 478 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rabbit anti MMP-13, Hinge Region MMP-13 Hinge Region...
Mouse monoclonal [SIT-01] to SIT ( Abpromise for all tested applications). entrezGeneID: 27240 SwissProtID: Q9Y3P8...
Biology Products: