Navigation Links
Imaging study sheds new light on alcohol-related birth defects
Date:8/22/2012

roscopy. Johnson, professor of radiology and physics, has developed new imaging tools with spatial resolution up to a million times higher than clinical magnetic resonance imaging (MRI). These include small bore tools suitable for imaging fetal mice that are only 15 mm long.

To quantify facial shape from MRI data, the study team turned to co-author Peter Hammond, a professor of computational biology at UCL's Institute of Child Health, in London. Hammond invented powerful new techniques for 3D shape analysis that have already proven successful in objectively defining facial shape changes in humans.

In the study, described in the August 22, 2012 issue of the online journal PLOS ONE, Lipinski and Sulik treated one group of mice with alcohol on their seventh day of pregnancy, a time corresponding to the third week of pregnancy in humans. A second group of mice was treated just 36 hours later, approximating the fourth week of human pregnancy. The amount of alcohol given was large, "high doses that most women wouldn't achieve unless they were alcoholic and had a tolerance for alcohol," Sulik said.

Near the end of pregnancy, the fetuses were then imaged at Duke University. These 3D data sets showed individual brain regions, as well as accurate and detailed facial surfaces, from which Hammond and research assistant and co-author Michael Suttie performed shape analyses.

The team found that the earlier alcohol exposure time elicited the classic FAS facial features, including characteristic abnormalities of the upper lip and eyes. What they observed in fetuses exposed just 36 hours later, however, was a surprise. These mice exhibited unique and in some cases opposing facial patterns, such as shortened upper lip, a present philtrum, and the brain, instead of appearing too narrow in the front, appeared wide.

"Overall, the results of our studies show that alcohol can cause more than one pattern of birth defects, and that t
'/>"/>

Contact: Tom Hughes
tahughes@unch.unc.edu
919-966-6047
University of North Carolina Health Care
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Stanford-SLAC team uses X-ray imaging to observe running batteries in action
2. Microcirculation imaging
3. Radiologists study necessity of additional imaging recommendations in PET/CT oncologic reports
4. Trial seeks improved lung-cancer screening by combining imaging and biomarkers
5. High-resolution atomic imaging of specimens in liquid by TEM using graphene liquid cell
6. More effective method of imaging proteins
7. Iowa State, Ames Lab researchers study the structure of drug resistance in tuberculosis
8. Study shows long-term effects of radiation in pediatric cancer patients
9. Organic study of live pancreatic tissue yields new opportunities for diabetes research
10. Turmeric spices up virus study
11. Bird louse study shows how evolution sometimes repeats itself
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Imaging study sheds new light on alcohol-related birth defects
(Date:7/28/2014)... The genome of Solanum pennellii , a wild ... an international group of researchers including the labs headed ... UC Davis Department of Plant Biology. The new genome ... , The work, published July 27 in the journal ... and colleagues at Aachen University in Germany. The UC ...
(Date:7/28/2014)... New research has identified areas of the Earth that ... climate change. , Europe is particularly vulnerable, as it ... four per cent, of any continent in ,refugia, ... natural environmental conditions remain relatively constant during times of ... Europe are mostly in Scandinavia and Scotland. , ...
(Date:7/28/2014)... YORK CITY (July 28, 2014)The Brain & Behavior ... annual Klerman and Freedman Prizes, recognizing exceptional clinical ... been supported by NARSAD Young Investigator Grants. The ... ideas in neurobiological and psychosocial research for the ... illnesses that affect one in four people. , ...
Breaking Biology News(10 mins):Study finds Europe's habitat and wildlife is vulnerable to climate change 2The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 2The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 3The Brain & Behavior Research Foundation names winners of Klerman and Freedman Prizes 4
... easy task to compare the environmental effects of battery ... The degree to which manufacture, usage and disposal of ... are detrimental to the environment is not exactly known. ... scientists have made a detailed life cycle assessment (LCA) ...
... world-wide collaboration of researchers has identified the first-ever genetic risk ... looked at the genetic data of more than 50,000 people, ... and they hope their research will open the door for ... that patients with a particular DNA variant on Chromosome 8 ...
... bigger hazard to the environment specifically to creatures that ... research from North Carolina State University toxicologists. In a ... One, the NC State researchers show that water fleas ... in agriculture as fertilizers and convert those chemicals into ...
Cached Biology News:'Greener' than expected 2'Greener' than expected 3First genetic link to common migraine exposed 2First genetic link to common migraine exposed 3Fertilizer chemicals linked to animal developmental woes 2
(Date:7/28/2014)... DALLAS , July 28, 2014 /PRNewswire/ ... research report  "Microbial Identification Market by Products (Consumables, Instruments, ... & Beverages), End User (Detection, Characterization) - ... global Microbial Identification Market is estimated at ... to reach $1,194.1 Million by 2019, growing ...
(Date:7/28/2014)... Boston, MA (PRWEB) July 28, 2014 ... with two researchers to further develop potential treatments for ... brain tumor, in combination with their patented vaccine platform, ... and Duke University, are based on the work of ... of Neurosurgery at The Preston Robert Tisch Brain Tumor ...
(Date:7/28/2014)... Appistry, Inc. , a leading provider ... of genomics to next-generation medicine, announced today its judging ... , Two Appistry staff will be joined by ... Genome Resources, and Mr. Neil Miller, director of informatics ... Rounding out the panel are Appistry’s Dr. Richard Mazzarella, ...
(Date:7/28/2014)... July 28, 2014 The global market ... by 2020, according to a new study by Grand ... rising demand for effective vaccines and drugs in an ... medical needs is expected to drive market demand over ... enhance agricultural productivity via the use of genetically engineered ...
Breaking Biology Technology:Microbial Identification Market worth $1,194.1 Million by 2019 2Microbial Identification Market worth $1,194.1 Million by 2019 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 2String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 3String of Collaborations Launch Immunomic Therapeutics’ Brain Tumor Program Pipeline 4Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 2Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 3Global Biotechnology Market Worth $604.40 Billion by 2020: Grand View Research, Inc 4
... member of Congress announces that a major reason to reform the ... does it like us. , ,Even during an era when America-bashing ... well - and has always done well - much to the ... things is innovation. In fact, the United States is the greatest ...
... - TomoTherapy saw its revenues surge by ... according to the first earnings report issued since ... also announced that it has joined a research collaboration with ... lower-cost proton therapy system for cancer treatment. , , First ...
... In Part I of this series on ... of Civil Procedure, which require parties to address and ... ("ESI"). Without a plan of attack or a system ... may unnecessarily be placing your company at risk. ...
Cached Biology Technology:Changes to U.S. patent law must nurture our culture of innovation 2Changes to U.S. patent law must nurture our culture of innovation 3Changes to U.S. patent law must nurture our culture of innovation 4TomoTherapy reports 86% revenue jump, $131M net loss in Q1 2TomoTherapy reports 86% revenue jump, $131M net loss in Q1 3Finding Safe Harbor in a sea of electronic discovery 2Finding Safe Harbor in a sea of electronic discovery 3
Protein Kinase D2 Immunogen: Human protein kinase D2. Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
... Upright Freezer Inventory Storage Racks ... configurations available to fit all makes ... refrigerators. Made of high quality ... 3" high fiberboard, stainless steel or ...
Many mammalian cell types and experimental situations create challenges for standard transfection experiments. The ViraPower Lentiviral Expression System overcomes these challenges with efficient vir...
Biology Products: