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If your first cigarette gave you a buzz and you now smoke, a gene may be to blame
Date:8/8/2008

appears that for people who have a certain genetic makeup, the initial physical reaction to smoking can play a significant role in determining what happens next," says senior author and project leader, Ovide Pomerleau, a professor of psychiatry at the University of Michigan Medical School and founder of the U-M Nicotine Research Laboratory.

"If cigarette smoking is sustained, nicotine addiction can occur in a few days to a few months," he adds. "The finding of a genetic association with pleasurable early smoking experiences may help explain how people get addicted and, of course, once addicted, many will keep smoking for the rest of their lives."

The researchers point out that the genetic variant explains only a portion of human smoking behavior, and that a more complete explanation of why people smoke and why they can't quit will require much more information about how genes interact with social influences and other environmental factors.

Pomerleau predicts that the ability to link behavioral patterns in smoking to individual genotypes will need extensive information concerning behavior, genes, and the environmental context as well as bioinformatic tools to bring it all together. "Understanding the genetics of complex disorders such as nicotine addiction will require much more research on key traits," he says.

The team notes that the CHRNA5 relationships appear to be strong and that practical applications from this research include new genetic tests for smoking risk and the development of medications that target smoking-risk genes.

Pomerleau states that the new paper builds on findings reported last year by fellow author Laura Bierut, in which a whole-genome study found that the same single nucleotide polymorphism, rs16969968, of the CHRNA5 gene was associated with smokers' level of nicotine dependence.

He also notes that, this year, three papers published independently of one another demonstrated that var
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Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

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