Navigation Links
If your first cigarette gave you a buzz and you now smoke, a gene may be to blame
Date:8/8/2008

ANN ARBOR, Mich. Anyone who has ever tried smoking probably remembers that first cigarette vividly. For some, it brought a wave of nausea or a nasty coughing fit. For others, those first puffs also came with a rush of pleasure or "buzz."

Now, a new study links those first experiences with smoking, and the likelihood that a person is currently a smoker, to a particular genetic variation. The finding may help explain the path that leads from that first cigarette to lifelong smoking.

The new finding also adds to growing suspicion surrounding the role of a particular nicotine-receptor gene in smoking-related behaviors and in lung cancer. Other researchers have already linked variations in the same genetic region to smokers' level of dependence on nicotine, to the number of cigarettes smoked per day and to a far higher risk of lung cancer the ultimate outcome of a lifetime of smoking.

In a paper published online today in the journal Addiction, a multi-university collaborative team of researchers specializing in statistical genetics, gene analysis, and trait analysis reports an association between a variant in the CHRNA5 nicotine receptor gene, initial smoking experiences, and current smoking patterns.

The genetic and smoking data come from 435 volunteers. Those who never smoked had tried at least one cigarette but no more than 100 cigarettes in their lives, and never formed a smoking habit. The regular smokers had smoked at least five cigarettes a day for at least the past five years.

The regular smokers in the study were far more likely than the never-smokers to have the less common rs16969968 form of the CHRNA5 gene, in which just one base-pair in the gene sequence was different from the more common form. This kind of genetic variation is called a single nucleotide polymorphism or SNP.

Smokers were also eight times as likely to report that their first cigarettes gave them a pleasurable buzz.

"It
'/>"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Which came first, the moth or the cactus?
2. First all-African GM crop is resistant to maize streak virus
3. Scientists retrace evolution with first atomic structure of an ancient protein
4. CU-Boulder team discovers first ancient manioc fields in Americas
5. First finding of a metabolite in 1 sex only
6. First orchid fossil puts showy blooms at some 80 million years old
7. First individual genome sequence published
8. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
9. UNH becomes first university in nation to use landfill gas as primary energy source
10. Scientists in first global study of poison gas in the atmosphere
11. Weight gain between first and second pregnancies associated with increased odds of male second child
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2014)... Warwick have discovered that ,good, cholesterol is turned ,bad, ... - MG, was found to damage ,good, HDL cholesterol, ... body. , Low levels of HDL, High Density ... levels of MG being common in the elderly and ... by funding from the British Heart Foundation (BHF) and ...
(Date:8/31/2014)... busy attacking us, germs go after each other. But ... for the infected microbes: Sometimes viruses actually carry helpful ... its diet or better attack its own hosts. , ... system would robotically destroy anything it recognized as invading ... now revealed that one variety of the bacterial immune ...
(Date:8/31/2014)... French . Montral, ... prestigious Nature Neuroscience journal by, Sylvain Williams, PhD, ... Mental Health University Institute and McGill University, opens the door ... controlling memory as well of the role of an essential ... , In 2009, they developed a unique approach ...
Breaking Biology News(10 mins):Sugar substance 'kills' good HDL cholesterol, new research finds 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 2Discovery reveals how bacteria distinguish harmful vs. helpful viruses 3Memory and Alzheimer's: Towards a better comprehension of the dynamic mechanisms 2
... can greatly impact biological species and ecosystems, requiring ... accommodate habitat shifts. Recorded data already show ... regions where their climatic requirements are better met. ... regulators on climate change implications for local conservation, ...
... continue to be energy-intensive and highly polluting for the foreseeable ... the agenda, according to a study published in the ... Xia of Dongbei University of Finance and Economics and the ... has looked at almost a decade,s worth of data from ...
... in the Department of Chemistry and Biochemistry at the ... Career Development Award from the National Science Foundation (NSF) ... to study the biophysics of model cell membranes, with ... will support the purchase of a computer cluster for ...
Cached Biology News:Workshop to focus on conservation management and climate change 2Polluting China for the sake of economic growth 2Patel recognized with NSF Career Award for computer-modeling research on cell membranes 2Patel recognized with NSF Career Award for computer-modeling research on cell membranes 3
(Date:8/29/2014)... Pittcon is pleased to announce that the 2015 ... Scientific, have organized a session on nanotechnology for presentation ... Asia’s largest analytical and scientific instruments show, will be ... , The four speakers in this U.S. symposium, “Thinking ... Single Cells” will present their use of nanotechnology to ...
(Date:8/29/2014)... Hills, NY (PRWEB) August 29, 2014 ... Burnt Hills Veterinary Hospital are seeking candidates to participate ... dogs with osteoarthritis. The ultimate goal of this ... donor stem cells into one or two arthritically affected ... treated joints. , Candidates for the current investigational ...
(Date:8/29/2014)... August 29, 2014 Due to a misstatement ... week, the Adult Stem Cell Technology Center, LLC ( ASCTC ... stem cell therapy research that might benefit ALS patients. ... for new stem cell technologies and therapeutic applications, FRC listed ... Bucket Challenge donors who wish not to support research ...
(Date:8/29/2014)... Boston, MA, San Antonio, TX (PRWEB) August 29, ... audited, ISO 9001:2008 and ISO 13485:2003 certified, GAMP® ... it has been awarded an international Phase II ... patients with non-Hodgkin’s lymphoma. , Throughout this trial, ... services including, but not limited to, protocol and ...
Breaking Biology Technology:Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2
... May 14 StemCor Systems, Inc., a,medical device ... today that it has been awarded a,National Institutes ... Grant entitled "Adult Stem Cell Minimally Invasive Bone ... MarrowMiner(TM) which,recently received 510(k) clearance from the U.S. ...
... 2008 - A team of five University of Akron ... role of temperature and humidity in PLoS ONE, an ... , The UA authors are Dr. Peter Niewiarowski, professor ... Ge, graduate assistant in polymer science; Emily Hagan (undergraduate ...
... Flow Cytometry Platforms, FRANKLIN LAKES, N.J., May 13 ... announced today that it has acquired all,of the outstanding ... Seattle that develops and markets advanced flow,cytometry cell sorting ... disclosed. The acquisition,is not expected to have a material ...
Cached Biology Technology:StemCor Systems, Inc. Awarded NIH SBIR Grant for Bone Marrow Aspiration Platform 2StemCor Systems, Inc. Awarded NIH SBIR Grant for Bone Marrow Aspiration Platform 3BD Announces Acquisition of Cytopeia 2BD Announces Acquisition of Cytopeia 3
EnzChek Ultra Xylanase Assay Kit *500 assays*...
Goat polyclonal to p27 KIP 1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: C-KRPATDDS STQNK, corresponding to Internal sequence amino acids 153-165 of Human p27 KIP 1 ...
Defender against cell death 1...
Wnt-1 (G-19)...
Biology Products: