Navigation Links
If your first cigarette gave you a buzz and you now smoke, a gene may be to blame
Date:8/8/2008

ANN ARBOR, Mich. Anyone who has ever tried smoking probably remembers that first cigarette vividly. For some, it brought a wave of nausea or a nasty coughing fit. For others, those first puffs also came with a rush of pleasure or "buzz."

Now, a new study links those first experiences with smoking, and the likelihood that a person is currently a smoker, to a particular genetic variation. The finding may help explain the path that leads from that first cigarette to lifelong smoking.

The new finding also adds to growing suspicion surrounding the role of a particular nicotine-receptor gene in smoking-related behaviors and in lung cancer. Other researchers have already linked variations in the same genetic region to smokers' level of dependence on nicotine, to the number of cigarettes smoked per day and to a far higher risk of lung cancer the ultimate outcome of a lifetime of smoking.

In a paper published online today in the journal Addiction, a multi-university collaborative team of researchers specializing in statistical genetics, gene analysis, and trait analysis reports an association between a variant in the CHRNA5 nicotine receptor gene, initial smoking experiences, and current smoking patterns.

The genetic and smoking data come from 435 volunteers. Those who never smoked had tried at least one cigarette but no more than 100 cigarettes in their lives, and never formed a smoking habit. The regular smokers had smoked at least five cigarettes a day for at least the past five years.

The regular smokers in the study were far more likely than the never-smokers to have the less common rs16969968 form of the CHRNA5 gene, in which just one base-pair in the gene sequence was different from the more common form. This kind of genetic variation is called a single nucleotide polymorphism or SNP.

Smokers were also eight times as likely to report that their first cigarettes gave them a pleasurable buzz.

"It
'/>"/>

Contact: Kara Gavin
kegavin@umich.edu
734-764-2220
University of Michigan Health System
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Which came first, the moth or the cactus?
2. First all-African GM crop is resistant to maize streak virus
3. Scientists retrace evolution with first atomic structure of an ancient protein
4. CU-Boulder team discovers first ancient manioc fields in Americas
5. First finding of a metabolite in 1 sex only
6. First orchid fossil puts showy blooms at some 80 million years old
7. First individual genome sequence published
8. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
9. UNH becomes first university in nation to use landfill gas as primary energy source
10. Scientists in first global study of poison gas in the atmosphere
11. Weight gain between first and second pregnancies associated with increased odds of male second child
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... Brazil -Individuals show great diversity in their ability to ... females greatly differ in their perceptual evaluation of odors, ... tests. , Sex differences in olfactory detection ... may be connected to one,s perception of smell, which ... women,s olfactory superiority has been suggested to be cognitive ...
(Date:11/4/2014)... In nature, the right amount of death at the ... density, according to new research that could help in ... wildlife stocks. , In a paper in the journal ... University researcher and European colleagues conclude that the kind ... a loss of individuals, or mortality, depends on the ...
(Date:11/4/2014)... 4, 2014) — Think about the way our bodies ... neighboring cells know that they are supposed to become ... these tissues find the correct place and alignment? Researchers ... crucial questions. , In a new study, UM researchers ... with their surrounding neighbors, at the head-trunk region. Their ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2When less is more: Death in moderation boosts population density in nature 2The inside story: How the brain and skull stay together 2
... from Holzmaden (Germany) that perished 182 million years ago ... the extinct marine reptile is almost immaculately preserved and ... in their anatomical position. The bones of the ichthyosaur ... part, they lie scattered outside the body of the ...
... the number of retractions in scientific journals is just the ... dysfunction that has been evolving the world of biomedical research ... before a committee of the National Academy of Sciences (NAS) ... some behaviors that are detrimental to good science," says Ferric ...
... particular genetic variants may be more prone to fatty liver ... and adolescents in industrialized countries, according to new findings by ... on three ethnic groups, is published in the March issue ... Nicola Santoro, M.D., associate research scientist in the Department of ...
Cached Biology News:Exploding dinosaur hypothesis implodes 2Has modern science become dysfunctional? 2
(Date:11/26/2014)... (PRWEB) November 25, 2014 The Pittcon ... its official conference and exposition mobile app, ... free download in the App Store for iOS and ... valuable resource tool before, during and after the event. ... details on exhibiting companies, technical sessions, Conferee Networking sessions ...
(Date:11/26/2014)... Boston, MA (PRWEB) November 26, 2014 ... and collaboration company is proud to announce that Darren ... Development and Sales. Darren will drive the ... and positive customer experience. , Darren brings ... He has held key roles in channel operations, from ...
(Date:11/26/2014)... TOKYO , 25 novembre 2014 Theravalues ... Super sur le marché européen au salon Hi ... Amsterdam ). Curcumine la ... une technologie amorphe (non-cristalline) à des ingrédients approuvés ... est un pigment jaune présent dans la racine ...
(Date:11/26/2014)... 2014  Roka Bioscience, Inc. (NASDAQ: ROKA ), ... for the detection of foodborne pathogens, today announced that ... 26 th Annual Healthcare Conference on December 2, 2014 ... New York Palace in New York, NY ... the Company, its operations, strategies and prospects may be discussed. ...
Breaking Biology Technology:Pittcon Releases 2015 Mobile App 2SoundConnect Appoints Director of Channel Development & Sales 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3Roka Bioscience to Present at the Piper Jaffray Healthcare Conference 2
... (Nasdaq: STAA ), a leading developer, manufacturer ... that the Afinity,Collamer(R) Aspheric foldable intraocular lens (IOL) ... Intraocular Lens (NTIOL) by the Centers for,Medicare and ... IOL,must first be an FDA approved IOL with ...
... Moody,s has raised the rating for the Gerresheimer ... As a result, the Group,s financial standing in ... Moody,s justifies,this step by reference to the considerably ... and in view of the Group,s increased,profitability and ...
... FRANCISCO, Calif., March 14 ,Renovis, Inc. (Nasdaq: RNVS ... of drugs for major medical needs in the areas ... fourth quarter and year ended December 31, 2007., ... December 31, 2007 was,$1.3 million and $9.8 million, respectively, ...
Cached Biology Technology:STAAR Surgical's Collamer(R) IOL Designated as a New Technology Intraocular Lens by the Centers for Medicare and Medicaid Services 2STAAR Surgical's Collamer(R) IOL Designated as a New Technology Intraocular Lens by the Centers for Medicare and Medicaid Services 3STAAR Surgical's Collamer(R) IOL Designated as a New Technology Intraocular Lens by the Centers for Medicare and Medicaid Services 4Moody's Raises Rating for Gerresheimer 2Renovis Reports Fourth Quarter and Full Year 2007 Financial Results 2Renovis Reports Fourth Quarter and Full Year 2007 Financial Results 3Renovis Reports Fourth Quarter and Full Year 2007 Financial Results 4Renovis Reports Fourth Quarter and Full Year 2007 Financial Results 5Renovis Reports Fourth Quarter and Full Year 2007 Financial Results 6Renovis Reports Fourth Quarter and Full Year 2007 Financial Results 7
... Tracker Intracellular Localization Kit provides a straight ... siRNA, of your design, in an efficient ... experiments. Subcellular localization and functional inhibition of ... introduction of the labeled siRNA into mammalian ...
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... Invasion Assay is designed to determine the ... a significant barrier to invasion or to ... a convenient, high-throughput, 96-well format. The 8 ... types of adherent cells such as epithelial, ...
... GrabIt™ Kits are designed for the study ... a pull-down method. Proteins that interact with ... fusion proteins are copurified using affinity resins ... retained on a spin filter. The complexes ...
Biology Products: