Navigation Links
Identified a subgroup of schizophrenia patients with motor disorders
Date:1/29/2014

Researchers led by Marta Barrachina, Institute of Neuropathology of the Bellvitge Biomedical Research Institute (IDIBELL) have identified a new subgroup of patients suffering from schizophrenia characterized by motor disorders.

The results of the study, which was conducted in collaboration with the research team Mairena Martin at the University of Castilla La Mancha at Ciudad Real and clinical researchers of the Health Park Sant Joan de Deu at Sant Boi de Llobregat, have been published in the online edition of the Journal of Psychiatric Research and was funded by the TV3 Marathon in the 2008 edition.

Schizophrenia is a serious mental illness. From a clinical point of view is considered grouping several diseases that are not well defined or characterized by biomarkers.

Barrachina team studies the A2A adenosine receptor, which is highly expressed in the basal ganglia at the central nervous system and is involved in the control of movement. Furthermore this protein inhibits the activity of dopamine D2 receptor, hyperactivated in schizophrenia patients and typical antipsychotics target.

"We studied the post- mortem brains of patients," explains Barrachina "and we found that 50% had very low levels of adenosine A2A receptor. Interestingly, when comparing these data with clinical information provided by the clinical investigators of the study, we note that these patients had motor disorders." "In addition, we identified an epigenetic mechanism associated with the decreased receptor expression."

According to the researcher, this finding allows to "identify a new subset of schizophrenia patients with motor disorders."

Proposal for combined therapy

This study opens the door to a clinical trial, based on radioimage, which would detect the levels of this protein and identify these patients and also to confirm the results obtained in the postmortem brains of patients. Barrachina team proposes to apply a specific combination therapy of antipsychotics and agonists of A2A adenosine. "Thus, the activity of adenosine A2A receptor will be favoured, reducing the dose of antipsychotics."


'/>"/>

Contact: Arantxa Mena
amena@idibell.cat
34-932-607-282
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. First dinosaurs identified from Saudi Arabia
2. New anti-HIV drug target identified by University of Minnesota researchers
3. Scientists identified T372R mutation as potential target for diagnosis and treatment of insulinoma
4. New target identified for preventing bone destruction in diseases such as arthritis and cancer
5. Treatment target identified for a public health risk parasite
6. Genetic signature identified for RSV, the leading cause of infant hospitalizations worldwide
7. Newly identified proteins make promising targets for blocking graft-vs.-host disease
8. New target to fight HIV infection identified
9. Baculovirus-recognizing human cell receptor identified for the first time
10. New dwarfism mutation identified in dogs
11. Inflammatory on and off switch identified for allergic asthma and COPD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/27/2018)... ... November 26, 2018 , ... PulseEd™ uses researched technology, published in the ... to stimulate blood flow to the penis. Regular and unimpeded blood flow to the ... for good erectile function. The recorded results of SWT (sound wave therapy), indicated that ...
(Date:11/20/2018)... ... November 19, 2018 , ... Cloudponics , maker of ... home, today announced a discount of $420 for its industry-leading product during the holiday ... paid in full, with other discount and payment options available on the Cloudponics ...
(Date:11/20/2018)... , ... November 20, 2018 , ... Like many large ... on. Before he was a year old, his mom, Rebecca, noticed he was ... him examined by her veterinarian and her suspicions were confirmed: Jack had bilateral hip ...
Breaking Biology News(10 mins):
(Date:11/13/2018)... ... November 13, 2018 , ... Renowned Honolulu veterinarian, Dr. ... the island of Kauai. Dr. Leadbeater, of Kahala Pet Hospital on ... Recently, he began traveling to the island of Kauai on an almost weekly ...
(Date:11/13/2018)... ... 13, 2018 , ... Aditya Humad, Managing Partner of ... asserts it is still trending upward with growing valuations based on a largely ... consolidation, pricing pressure and increased competition as reasons often cited by institutional investors ...
(Date:11/11/2018)... (PRWEB) , ... November 09, 2018 , ... Triple W, ... CES® 2019 Innovation Awards Honoree for DFree ®, the first health ... you when it’s time to go to the bathroom. The announcement was made during ...
(Date:11/9/2018)... ... November 08, 2018 , ... Superior Controls, Inc. , ... with 140 employees on both the east and west coasts, today announced the ... Center on November 14 and 15 in Philadelphia. The event is hosted by ...
Breaking Biology Technology: