Navigation Links
Identified a new possible target to combat muscle wasting
Date:4/9/2014

In the study published today in the Journal of Clinical Investigation (JCI), one of the journals with highest impact in experimental medicine, the researchers associate the activity of the DOR protein with muscle atrophy and point to DOR as a plausible target against which to develop a drug to prevent muscle deterioration in certain diseases.

DOR (Diabetes- and Obesity-regulated gene), also known as TP53INP2, is a protein involved in autophagy, a quality control process that ensures cells stay healthy. The researchers have found that increased DOR expression in the muscle of diabetic mice leads to enhanced autophagy, which in turn favours the loss of muscle mass in these animals.

The advantage of developing a DOR inhibitor is that autophagy, a process necessary to keep cells healthy, would not be completely blocked in the absence of this protein. DOR is not essential for autophagy, but acts more as an accelerator. Thus, the inhibition of DOR would only partially reduce autophagy as other molecules involved would exert their activity normally, thus maintaining the levels of autophagy in a beneficial range for cells.

"If we could treat patients with sarcopenia and cachexia, or people at risk of these conditions, using a drug to inhibitor DOR then we would be able to stop or prevent muscle wasting," explains the expert in diabetes and obesity Zorzano, head of the "Heterogenic and Polygenic Diseases" lab at IRB.

"We are showing pharmaceutical researchers a new possible therapeutic target for two diseases that seriously impair the quality of lives of those who suffer from them," says the scientist.

An answer to why type 2 diabetic patients lose less muscle than those with type 1

The study also solves a biomedical enigma related to diabetes. Physicians did not understand why patients with type 2 diabeteswho become resistance to insulin or have very low levels of this hormoneare able to maintain muscle mass or minimize muscle wasting compared to patients with type 1 diabeteswho do not produce insulinwho show a clear loss of muscle mass. The IRB researchers demonstrate that the repression of DOR in muscle cells of type 2 diabetic animals allows the maintenance of muscle mass.

"We interpret DOR repression, which occurs naturally, as an adaptation mechanism to preserve muscle mass and to maintain greater muscular strength in type 2 diabetics," explains David Sala, first author of the study, who has recently started a post-doctoral training period at Sanford-Burnham Medical Research Institute, in La Jolla, California.

Besides working with mice, the scientists have performed experiments on biopsies from skeletal muscle of patients with diabetes and patients resistant to insulin, thanks to collaboration with clinicians from the Universit Lyon 1, in France, and from the Medical University of Byalistok, Poland, also included among the authors.


'/>"/>

Contact: Sònia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Related biology news :

1. Planarian genes that control stem cell biology identified
2. Hiding in plain sight, a new frog species with a weird croak is identified in New York City
3. Common North American frog identified as carrier of deadly amphibian disease
4. Culprit behind unchecked angiogenesis identified
5. Gene mutation identified as contributor to autism spectrum disorders
6. Researchers identified a protein useful in predicting the risk of pulmonary metastases in breast cancer patients
7. Researchers have identified a gene with a key role in neuronal survival
8. Like curry? New biological role identified for compound used in ancient medicine
9. Jack Spratt diabetes gene identified
10. A new indicator for breast cancer relapse identified
11. Parkinsons disease gene identified with help of Mennonite family: UBC-VCH research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Identified a new possible target to combat muscle wasting
(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/18/2017)... 18, 2017  Socionext Inc., a global expert in SoC-based imaging ... server, the M820, which features the company,s hybrid codec technology. A ... Tera Probe, Inc., will be showcased during the upcoming Medtec Japan ... at the Las Vegas Convention Center April ... Click here for ...
(Date:4/13/2017)... , April 13, 2017 UBM,s Advanced Design ... will feature emerging and evolving technology through its ... Summits will run alongside the expo portion of the ... panels and demonstrations focused on trending topics within 3D ... design and manufacturing event will take place June 13-15, 2017 ...
Breaking Biology News(10 mins):
(Date:7/27/2017)... ... July 27, 2017 , ... Margot Connor, ... position on Baltimore Business Journal’s 2017 Tech 10 List of “outstanding professionals in ... peers for contributions to the technology industry within their local community. Honorees are ...
(Date:7/26/2017)... California (PRWEB) , ... July 26, 2017 , ... ... Intelligence (AI) and leading supplier of Semantic Graph Database technology for Knowledge Graphs, ... exploring and discovering connections within data. Gruff provides novice users and graph experts ...
(Date:7/26/2017)... ... July 25, 2017 , ... ... to announce that its regenerative stem cell therapy has been used on more ... successful treatment for horses with potentially fatal injuries to tendons and ligaments. , ...
(Date:7/26/2017)... ... July 26, 2017 , ... Joni Rutter, Director of Scientific ... Health (NIH), will be one of the esteemed presenters at the 9th Annual ... multi-stakeholder discussion on the latest advancements in the precision and personalized medicine field. ...
Breaking Biology Technology: