Navigation Links
Identification of stem cells raises possibility of new therapies
Date:4/30/2013

WINSTON-SALEM, N.C., April 30, 2013 Many diseases obesity, Type 2 diabetes, muscular dystrophy are associated with fat accumulation in muscle. In essence, fat replacement causes the muscles to weaken and degenerate.

Scientists at Wake Forest Baptist Medical Center have discovered the biological mechanism involved in this process, which could point the way to potential therapies. The findings are published in the April 27 online edition of Stem Cells and Development.

The Wake Forest Baptist researchers proved that pericytes, stem cells associated with blood vessels, contain two sub-types with completely different roles: Type 1, which forms only fat cells, and Type 2, which forms only muscle cells.

"We found that Type 1 contributes to fat accumulation in the skeletal muscle under pathogenic conditions, while Type 2 helps in forming muscle," said Osvaldo Delbono, M.D., Ph.D., professor of internal medicine at Wake Forest Baptist and senior author of the study.

"This is important because now we have the potential to develop therapies that can block the activity of Type 1 pericytes to form fat or activate Type 2 pericytes to regenerate muscle."

In the study, the researchers were able to identify the subtypes through genetic and molecular labeling methods. Using an in vitro model, they showed that Type 1 pericytes form fat while Type 2 pericytes form muscle.

To test their theory in an animal model, first they injected Type 2 cells into injured muscle in healthy young mice to determine if the muscle would regenerate to repair the damage; it did. When Type 1 cells were injected, they did not form muscle.

Next, to simulate what happens in diseases such as diabetes and muscular dystropy, the researchers injected glycerol into healthy mice to induce fat accumulation in the muscle. When Type 1 pericytes were injected into the disease model, they formed fat, not muscle. When Type 2 pericytes were injected into the disease model, nothing happened.

"Our results indicate that Type 1 and Type 2 pericytes may play a critical role in successful muscle regeneration, which results from a balance between different cells in the skeletal muscle," said Alexander Birbrair, a doctoral student in Delbono's lab and first author of the study. "This study proves that each type of pericyte has a completely different role in the body. We suggest that Type 1 pericytes could be used as a cellular target for therapy to diminish fat accumulation in the muscle."

Based on these findings, Delbono's team is planning to conduct a new study using biopsied human tissue to determine if the same mechanism holds true in people.


'/>"/>

Contact: Marguerite Beck
marbeck@wakehealth.edu
336-716-2415
Wake Forest Baptist Medical Center
Source:Eurekalert

Related biology news :

1. Source identification of H7N9 influenza virus causing human infections
2. More accurate, sensitive DNA test allows early identification of fungus causing WNS
3. University of Illinois researchers develop AFM-IR for nanometer scale chemical identification
4. Neurotechnology Launches SkyBiometry Spin-off Company to Deliver SaaS Biometric Identification and Feature Analysis
5. After 121 years, identification of grave robber fossil solves a paleontological enigma
6. Scientists discover new method of gene identification
7. IdentiSys acquires the Identification, Security and Presentation Divisions of Mountainland Business Systems, a Utah based reseller
8. Digicel Launches Worlds First Biometric Identification System For International Money Transfers
9. Identification of differential proteins in maternal serum with Down syndrome
10. SRI Sarnoffs Iris on the Move® N-Glance™ Identification System Receives Lenel Factory Certification
11. APS issues new policy requiring identification of sex or gender in reporting scientific research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2016)... NEW YORK , June 1, 2016 ... Biometric Technology in Election Administration and Criminal Identification to ... According to a recently released TechSci Research report, " ... Sector, By Region, Competition Forecast and Opportunities, 2011 - ... $ 24.8 billion by 2021, on account of growing ...
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC ... today announced the opening of an IoT Center of ... strengthen and expand the development of embedded iris biometric ... unprecedented level of convenience and security with unmatched biometric ... one,s identity aside from DNA. EyeLock,s platform uses video ...
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016 Andrew ... http://doi.org/10.17925/OHR.2016.12.01.22 Published recently in ... journal from touchONCOLOGY, Andrew D Zelenetz , ... cancer care is placing an increasing burden on ... biologic therapies. With the patents on many biologics ...
(Date:6/23/2016)... CA (PRWEB) , ... June 23, 2016 , ... ... software, is exhibiting at the Pennsylvania Convention Center and will showcase its product’s ... conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical Trials ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, a division ... tuned and optimized exclusively for Okuma CNC machining centers at The International Manufacturing ... collaboration among several companies with expertise in toolholding, cutting tools, machining dynamics and ...
(Date:6/23/2016)... June 23, 2016 ReportsnReports.com ... report to its pharmaceuticals section with historic and ... and much more. Complete report on ... pages, profiling 15 companies and supported with 261 ... http://www.reportsnreports.com/reports/601420-global-cell-culture-media-industry-2016-market-research-report.html . The Global Cell ...
Breaking Biology Technology: