Navigation Links
Identification of protein able to stimulate production of T-cells
Date:7/22/2008

lar markers that are specific to the different stages of cell maturation, IRIC researchers determined that elevated levels of Wnt4 led to a marked increase in the number of white blood cell progenitors, and of immature T cells in the thymus in particular.

Conversely, they found that deletion of the Wnt4 gene and lack of the corresponding protein was associated with a decrease in the number of T cell progenitors in the thymus.

After showing that Wnt4 could stimulate thymopoiesis, the name given to the production of T cells in the thymus, Dr. Perreault and his team sought to understand the mode of action of the protein. Isabelle Louis, a graduate student, and Dr. Krista Heinonen, a postdoctoral fellow, analyzed the changes in gene activity triggered by exposure to

Wnt4. Results were conclusive: Wnt4 increases the number of T cell progenitors by inducing the expression of genes involved in cell survival. IRIC researchers also showed that Wnt4 does not mediate these changes in gene expression through the intracellular pathway normally activated by members of the Wnt family, i.e. stabilization of a signalling protein called -catenin, but rather through an alternative pathway involving members of the JNK family of proteins. The IRIC team is now investigating ways to capitalize on its discovery to develop new therapeutic agents.


'/>"/>

Contact: Christian Lanctt
christian.lanctot@umontreal.ca
51-434-361-110-315
University of Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. Platinum Solutions, Inc. Teams with Lockheed Martin on Federal Bureau of Investigations Next Generation Identification Program
2. Neurotechnology Announces MegaMatcher 2.1 SDK for Development of Large-scale AFIS and Multi-biometric Face-Fingerprint Identification Systems
3. BIO-key(R) Granted Image Identification System Patent for Award Winning Biometric Technology
4. Motorola Biometric Identification System Selected by West Virginia State Police
5. BIO-key(R) to Showcase Biometric Identification Technology at 2008 RSA Conference
6. BIO-key(R) to Showcase Biometric Identification Technology at 2008 RSA Conference
7. Motorola Biometric Identification System Selected by West Virginia State Police
8. Titanium Group Announces Launch of New Identification Solution Targeting High Growth Retail Sector
9. Identification of a novel class of (not-so) small RNAs
10. Cogent Systems and Northrop Grumman Reach Agreement to Settle Automated Fingerprint Identification Technology Suit and Create Strategic Alliance
11. Cogent Systems and Northrop Grumman Reach Agreement to Settle Automated Fingerprint Identification Technology Suit and Create Strategic Alliance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... examples of complex systems. Their infrastructure equipment requires ... cooling, transport to supply fuel, and ICT systems ... network chain is interconnected with a wider network ... of UK-based scientists has studied various aspects of ... been published in EPJ B by Gaihua Fu ...
(Date:8/28/2014)... This news release is available in German . ... electronic products are now built with the help of sophisticated ... are fixed, are an important part of these assembly lines. ... are attached in various work stages arranged in a precise ... the end of the line. , The creation of such ...
(Date:8/28/2014)... Protected areas conserve biodiversity and more action is needed ... areas, researchers say. , Published in PLOS ONE ... University of Exeter, used meta-analysis - combining results from ... years of research into these areas, to determine whether ... School of Biological Sciences, said protecting an area from ...
Breaking Biology News(10 mins):Inter-dependent networks stress test 2Nanoscale assembly line 2Nanoscale assembly line 3Protected areas proven to protect biodiversity 2
... Irvine, Calif., July 12, 2011 UC Irvine researchers ... customized therapies for virulent flu strains that resist current ... Amaro and Robin Bush created a method to predict ... promoting viral replication can be identified as these proteins ...
... The National Heart, Lung and Blood Institute, one of ... at the Johns Hopkins University School of Medicine each ... establish two Programs of Excellence in Glycosciences. Gerald Hart, ... professor of pharmacology and molecular sciences, will lead these ...
... Beach, FL. New research findings to be presented ... Study of Ingestive Behavior (SSIB), the foremost society for research ... ghrelin, a natural gut hormone that stimulates feeding, also modulates ... dopamine levels within the striatum, a critical component of the ...
Cached Biology News:UCI study points to new means of overcoming antiviral resistance in influenza 2Johns Hopkins researchers awarded $32 million 2
(Date:8/28/2014)... Best Sanitizers, Inc., a leader in hand ... is asking industry professionals to prepare for fall harvest ... soap they’re currently using to the Best Sanitizers’ ... hygiene is critical to fighting cross-contamination and the spread ... criteria are identified to evaluate the effectiveness of an ...
(Date:8/28/2014)... , Aug. 28, 2014 /PRNewswire/ ... new market research report is ... Whole Exome Sequencing Market ... Preparation, Target Enrichment), by Services ... Synthesis), by Application (Cancer, Monogenic ...
(Date:8/28/2014)... PARK, Calif. , Aug. 28, 2014 /PRNewswire/ ... focused on developing novel mid- to late-stage cardiovascular ... $7.0 million in its first round of financing. ... Biomedical Investments and Hercules Bioventures with participation from ... entrepreneur and pharmaceutical executive, Dr. Larry Hsu ...
(Date:8/28/2014)... PrimeSource Building Products, Inc., a ... SoundConnect to support their communication needs with ... web conferencing platform GlobalMeet powered by SoundConnect. The ... SoundConnect delivers award winning “results driven” business ... will be utilizing GlobalMeet powered by SoundConnect ...
Breaking Biology Technology:Best Sanitizers, Inc. Asks Food Industry Professionals: With Fall Harvest On the Way, Is Your E2 Hand Soap Up to the Task? 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 2Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 3Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 4Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 5Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 6Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 7Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 8Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 9Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 10Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 11Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 12Whole Exome Sequencing Market by Product (Systems, Kits (Library Preparation, Target Enrichment), by Services (Sequencing), by Technology (Sequencing by Synthesis), by Application (Cancer, Monogenic disorders) - Global Forecast to 2018 13Armetheon Completes $7.0 Million Series A Financing 2Armetheon Completes $7.0 Million Series A Financing 3PrimeSource Chooses SoundConnect as Collaboration Provider 2
... PALO ALTO, Calif., Feb. 7 Avicena Group, ... that,develops central nervous system therapeutics for neurodegenerative,disorders, announced ... Nivaggioli, Ph.D., will present an overview of the ... BIO CEO & Investor,Conference to be held February ...
... Feb. 7 Logical Therapeutics, Inc., a,biotechnology company ... associated with poorly controlled inflammation, announced today,that its ... presented with the,Distinguished Investigator Award from the American ... Care Congress of the Society of Critical,Care Medicine ...
... Home-Based Device Market Featuring Diode Laser ... Technology for Hair ... in,light-based therapeutic beauty devices, today announced over-the-counter,(OTC) clearance from the ... laser hair removal device designed for at-home,use. The TRIA is ...
Cached Biology Technology:Avicena Group to Present at 10th Annual BIO CEO & Investor Conference 2Avicena Group to Present at 10th Annual BIO CEO & Investor Conference 3Logical Therapeutics Co-Founder and CEO Honored with a Distinguished Investigator Award from the American College of Critical Care Medicine 2TRIA At-Home Laser Hair Removal Device Cleared by FDA 2
...
Anti-Indolamine (Indoleamine) 2,3-dioxygenase Immunogen: Recombinant human IDO. Available Date: 38454...
Anti-Ephrin B1 Host: rabbit polyclonal Species Reactivity: human Applications: WB Storage: 4C...
Human Regulatory T cell Staining Kit #2 (w/ APC Foxp3 PCH101, FITC CD4, PE CD25)...
Biology Products: