Navigation Links
Identification of protein able to stimulate production of T-cells
Date:7/22/2008

lar markers that are specific to the different stages of cell maturation, IRIC researchers determined that elevated levels of Wnt4 led to a marked increase in the number of white blood cell progenitors, and of immature T cells in the thymus in particular.

Conversely, they found that deletion of the Wnt4 gene and lack of the corresponding protein was associated with a decrease in the number of T cell progenitors in the thymus.

After showing that Wnt4 could stimulate thymopoiesis, the name given to the production of T cells in the thymus, Dr. Perreault and his team sought to understand the mode of action of the protein. Isabelle Louis, a graduate student, and Dr. Krista Heinonen, a postdoctoral fellow, analyzed the changes in gene activity triggered by exposure to

Wnt4. Results were conclusive: Wnt4 increases the number of T cell progenitors by inducing the expression of genes involved in cell survival. IRIC researchers also showed that Wnt4 does not mediate these changes in gene expression through the intracellular pathway normally activated by members of the Wnt family, i.e. stabilization of a signalling protein called -catenin, but rather through an alternative pathway involving members of the JNK family of proteins. The IRIC team is now investigating ways to capitalize on its discovery to develop new therapeutic agents.


'/>"/>

Contact: Christian Lanctt
christian.lanctot@umontreal.ca
51-434-361-110-315
University of Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. Platinum Solutions, Inc. Teams with Lockheed Martin on Federal Bureau of Investigations Next Generation Identification Program
2. Neurotechnology Announces MegaMatcher 2.1 SDK for Development of Large-scale AFIS and Multi-biometric Face-Fingerprint Identification Systems
3. BIO-key(R) Granted Image Identification System Patent for Award Winning Biometric Technology
4. Motorola Biometric Identification System Selected by West Virginia State Police
5. BIO-key(R) to Showcase Biometric Identification Technology at 2008 RSA Conference
6. BIO-key(R) to Showcase Biometric Identification Technology at 2008 RSA Conference
7. Motorola Biometric Identification System Selected by West Virginia State Police
8. Titanium Group Announces Launch of New Identification Solution Targeting High Growth Retail Sector
9. Identification of a novel class of (not-so) small RNAs
10. Cogent Systems and Northrop Grumman Reach Agreement to Settle Automated Fingerprint Identification Technology Suit and Create Strategic Alliance
11. Cogent Systems and Northrop Grumman Reach Agreement to Settle Automated Fingerprint Identification Technology Suit and Create Strategic Alliance
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... , Dec. 9, 2014  Wake Forest Baptist Medical Center ... for its School of Medicine. Funding for this $50 ... campaign that will be publicly launched next summer. ... in the former 60 series R.J. Reynolds Tobacco Company ... Construction will begin immediately with plans to be ready ...
(Date:12/5/2014)... MOUNTAIN VIEW, Calif. , Dec. 4, 2014 ... and safety has boosted investments in new testing ... products has also given rise to a range ... driven by the requirements of Generation Y, which ... digital technologies. As a result, product development strategies ...
(Date:12/3/2014)... , Dec. 2, 2014 As part of ... Inception Technologies is pleased to announce the release of ... customers to collect the workforce data that they need. ... have been left by existing readers. Many such devices ... connectivity and modern technology. Older models force users to ...
Breaking Biology News(10 mins):Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 2Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 3Wake Forest Baptist to Build New Medical Education Facility In Wake Forest Innovation Quarter 4Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2
... have been identified as highly efficient generators of electricity. , ... high concentrations in the stratosphere orbiting the earth with the ... biofilm that has been engineered by a team of scientists ... from the Wear Estuary, Country Durham, UK, the team tested ...
... N.M Sandia National Laboratories researchers, using off-the-shelf ... on ways to improve amputees, control over prosthetics ... Organic materials chemist Shawn Dirk, robotics engineer Steve ... The goal is improved prosthetics with flexible nerve-to-nerve ...
... Researchers at The Pennsylvania State University College of ... integrity of the opioid growth factor receptor (OGFr), which ... on cell proliferation, is a key to understanding the ... of human ovarian cancer cells that were molecularly engineered ...
Cached Biology News:Superbugs from space offer new source of power 2Sandia seeks better neural control of prosthetics for amputees 2Sandia seeks better neural control of prosthetics for amputees 3Sandia seeks better neural control of prosthetics for amputees 4Sandia seeks better neural control of prosthetics for amputees 5A breakthrough in understanding the biology and treatment of ovarian cancer 2A breakthrough in understanding the biology and treatment of ovarian cancer 3
(Date:12/24/2014)... China Biologic Products, Inc. (NASDAQ: CBPO, ... integrated plasma-based biopharmaceutical company in China ... Shandong Taibang Biological Products Co. Ltd., has received ... Food and Drug Administration (the "CFDA") for its ... in the Company,s public filings, the CFDA inspected ...
(Date:12/24/2014)... Sigma-Aldrich Corporation (NASDAQ: SIAL ... the Hart-Scott-Rodino Antitrust Improvements Act (HSR Act) in ... 2014, thereby completing the U.S. HSR Act antitrust ... the Company by Merck KGaA, Darmstadt, Germany.  ... to closing the transaction, which remains subject to ...
(Date:12/22/2014)... Malvern, PA & Brussels (PRWEB) December 22, 2014 ... Education (CfPIE), the global leader of technical training ... Society for Clinical Data Management (SCDM) to ... training and certification programs —providing access to the ... The partnership extends SCDM members with 10% off when ...
(Date:12/22/2014)... N.C. , Dec. 22, 2014  Alternative ... announced that it has signed a letter of ... that has developed and patented a nanotechnology-based development ... diagnostics products that enable rapid on-site collection and ... use/abuse and health issues in an immediate, non-invasive ...
Breaking Biology Technology:China Biologic Receives GMP Certification for New Coagulation Factor Facility 2China Biologic Receives GMP Certification for New Coagulation Factor Facility 3Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 2Acquisition of Sigma-Aldrich by Merck KGaA, Darmstadt, Germany, Receives U.S. Antitrust Clearance 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3ALNE Announces Intention To Acquire BioTechPharma 2
... N.J., Feb. 5 Covance Inc. (NYSE:,CVD) today announced ... Biotechnology and Medical Device Conference on February 6th,at 9:20 ... the presentation at, http://www.covance.com . In order to register ... early., Covance, with headquarters in Princeton, New Jersey, ...
... 5 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq:,ONTY) (TSX: ONY), ... therapeutic products for the treatment of cancer, today,announced ... http://www.oncothyreon.com ., "We are excited about ... updated website, which provides additional information about our,product ...
... (Nasdaq: KERX ) today announced that Michael S. Weiss, ... the following,upcoming Investor Conferences:, Thursday, February 7th, 2008 - ... & Medical,Device Conference, Grand Hyatt Hotel ... 12:30 PM ET: BIO CEO & Investor Conference ...
Cached Biology Technology:Keryx Biopharmaceuticals Announces Upcoming Corporate Presentations 2
... to Cytokeratin 5 / 6 Cytokeratin ... weight, basic type of cytokeratin expressed in ... layers of stratified epithelia as well as ... cells and mesothelioma. Cytokeratin 6 (56 kD) ...
Aldolase A (N-15)...
... Y2 Receptor antiserum This NPY Y2 ... level and is currently being characerized in brain. ... and mouse and appears to work better on ... rat. For full characterizarion in dorsal root ganglion ...
Black Polypropylene 384 Round Well Plate 70/Box...
Biology Products: