Navigation Links
Identification of differential proteins in maternal serum with Down syndrome
Date:6/7/2012

Prenatal screening for Down syndrome (DS) is still in need of improvement. Perinatal medicine experts have worked hard to find new biomarkers for screening of DS. Dr. Shi he Shao and his co-investigators, from Jiangsu University and Changzhou Woman and Children Health Hospital, report in the May 2012 issue of Experimental Biology and Medicine that they have successfully identified twenty-nine differentially expressed proteins in maternal serum from pregnancies carrying DS fetuses with proteomic approaches. These differential proteins offer the possibility of improving the performance of DS screening in the future. The functional roles of these proteins also possibly have a relationship with the development of DS.

Dr. Shao said "To date, a very limited number of studies have been carried out to analyze maternal blood in search for biomarkers of DS." "We have successfully identified the greatest number of potential DS biomarker proteins in maternal serum."

Dr. Yu said "We used the proteomic approaches of two dimensional gel electrophoresis (2-DE) and MALDI mass spectrometry and they proved to be of benefit in identifying potential serum biomarkers to detect DS."

Dr. Qiu wei Wang said "Among 29 proteins, two proteins ceruloplasmin and complement factor B (CP and CFB) were the most notable. Both were significantly increased in DS maternal serum and their functional roles suggest a relationship with the development of DS."

These differential proteins offers the possibility of further improving the performance of DS screening but Dr. Shao concludes that "it still needs clinical verification as a prenatal screen and we will conduct corollary studies to understand how these candidate proteins are related to the etiology and function of DS."

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "Prenatal screening for Down Syndrome has a rate of detection which is at best 75 to 85% with a 5% false positive rate and a lower rate of detection found in developing countries. The proteomic approach of Shao and colleagues offers new biomarkers which could lead to higher rates of detection and lower false positive rates. Further clinical testing of this approach is warranted based on this study."


'/>"/>

Contact: Shi-he Shao
shaoshihe2006@163.com
Society for Experimental Biology and Medicine
Source:Eurekalert

Related biology news :

1. SRI Sarnoffs Iris on the MoveĀ® N-Glanceā„¢ Identification System Receives Lenel Factory Certification
2. APS issues new policy requiring identification of sex or gender in reporting scientific research
3. Speeding up drug discovery with rapid 3-D mapping of proteins
4. A non-invasive intracellular thermometer with fluorescent proteins has been created
5. Discovered a new checkpoint of cell cycle control through joint action of 2 proteins
6. UCLA researchers develop way to strengthen proteins with polymers
7. Discovery of plant proteins may boost agricultural yields and biofuel production
8. Discovery of a new family of key mitochondrial proteins for the function and viability of the brain
9. Gold nanoantennas detect proteins
10. More effective method of imaging proteins
11. Researcher who identifed genetic cause and possible treatment for Marfan syndrome honored
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/30/2016)... FRANCISCO and WARSAW, Poland , Nov. 30, 2016 /PRNewswire/ ... It is one of the most crucial aspects of recovery so we need to ... of serious health risks, including heart problems, high blood pressure, stroke, diabetes, and even ... and friends sleep and find a Christmas present that could help them to manage ... ...
(Date:11/29/2016)... VILNIUS, Lithuania , Nov. 29, 2016 ... high-precision biometric identification and object recognition technologies, ... kit (SDK) for fingerprint recognition solutions that ... extract a fingerprint template using less than ... used in compact devices that have limited ...
(Date:11/24/2016)... IRVINE, Calif. , Nov. 23, 2016 ... help endurance athletes and their trainers non-invasively measure ... Variability Index, Pulse Rate, and Respiration Rate in approximately ... Ember enables users easy and immediate access to key ... as part of a training regimen. ...
Breaking Biology News(10 mins):
(Date:12/6/2016)... ... December 06, 2016 , ... Superior Controls, Inc ... today announced the company has successfully completed its 50th consecutive audit. For ... systems integration services to leading companies in life sciences, food and beverage, energy ...
(Date:12/6/2016)... -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ... of its previously-announced cash tender offers (the "Offers") ... accrued and unpaid interest to, but not including, ... expenses related to the Offers) (the "Maximum Tender ... table below (collectively, the "Notes"). The terms and ...
(Date:12/5/2016)... , Dec. 5, 2016 Axovant Sciences ... biopharmaceutical company focused on the treatment of dementia, today ... for the treatment of Alzheimer,s disease will be presented ... Meeting on Friday, December 9, 2016 in ... show results of both simple and complex measures of ...
(Date:12/5/2016)... December 5, 2016 According ... Market, by Products (Consumable, Instruments, Automated Cell Expansion ... and Stem Cell Research, Cancer, and Cell-Based Research), ... Banks) - Global Revenue, Trends, Growth, Share, Size ... Research, the global cell expansion market is expected ...
Breaking Biology Technology: