Navigation Links
Identification of a key molecular pathway required for brain neural circuit formation
Date:5/15/2009

Montral, May 15, 2009 The research group of Dr. Frdric Charron, a researcher at the Institut de recherches cliniques de Montral (IRCM), has made a discovery which could help treat spinal cord injuries and neurodegenerative diseases. This new finding has been published in the current issue of the prestigious scientific journal Neuron. Patricia T. Yam, Sbastien D. Langlois and Steves Morin, all at the IRCM, are listed as co-authors.

The brain is composed of billions of interconnected neurons. To correctly form neuronal circuits, the developing axons (a long extension of a neuron) require attractive and repulsive molecules to lead them to their appropriate targets. One such molecule is Sonic Hedgehog (Shh). Five years ago, as a postdoctoral fellow in the laboratory of Dr. Marc Tessier-Lavigne at Stanford University, Frdric Charron discovered that Shh acted as an axonal attractant for brain and spinal cord neurons. "How exactly Shh elicited this effect has remained unknown so far," pointed out Dr. Charron. "The molecular pathway my team discovered provides part of an answer."

Their recent work showed that Shh exerts its attractive effect through a group of molecules called Src family kinases (SFKs) that, until now, were not known to be linked to Shh function. Remarkably, these novel Shh effector molecules are absolutely required for the ability of Shh to guide axons. Connecting axons with an appropriate set of targets is very complex. Inappropriate wiring or damage to these neuronal connections leads to severe abnormalities of the nervous system. "Knowing the effectors of axon guidance molecules such as Shh", adds Dr. Charron, "helps us to understand the molecular mechanisms by which axons reach their target. It paves the way to new therapies to treat spinal cord injuries, neurodevelopmental disorders, and neurodegenerative diseases."

This new discovery was made possible through the invention of a novel technique to control and observe the behavior of axons in response to guidance molecules. A patent application for this technique has been filed recently. This invention is expected to speed up the discovery of drugs that control axon pathfinding.

"Dr. Charron is one of the country's leading newly arrived neuroscientists. This research has important long-term implications for the repair of spinal cord injury: if we knew all of the molecules required to guide axons correctly during spinal cord healing, we would probably know how to heal spinal cord injuries," says Dr. Rod McInnes, Scientific Director of the Canadian Institutes of Health Research Institute of Genetics. "This is beautiful research that adds another major brick to our building a complete understanding of how the spinal cord is made, and how injury of it can be treated."


'/>"/>

Contact: Olivier Lagueux
olivier.lagueux@ircm.qc.ca
514-987-5555
Institut de recherches cliniques de Montreal
Source:Eurekalert

Related biology news :

1. M2SYS Partners With Gnosis Medical Services to Provide Accurate Patient Identification in Developing Countries Through Innovative Biometrics Solution
2. Cogent Systems and Northrop Grumman Reach Agreement to Settle Automated Fingerprint Identification Technology Suit and Create Strategic Alliance
3. Cogent Systems and Northrop Grumman Reach Agreement to Settle Automated Fingerprint Identification Technology Suit and Create Strategic Alliance
4. Identification of a novel class of (not-so) small RNAs
5. Titanium Group Announces Launch of New Identification Solution Targeting High Growth Retail Sector
6. Motorola Biometric Identification System Selected by West Virginia State Police
7. BIO-key(R) to Showcase Biometric Identification Technology at 2008 RSA Conference
8. BIO-key(R) to Showcase Biometric Identification Technology at 2008 RSA Conference
9. Motorola Biometric Identification System Selected by West Virginia State Police
10. BIO-key(R) Granted Image Identification System Patent for Award Winning Biometric Technology
11. Neurotechnology Announces MegaMatcher 2.1 SDK for Development of Large-scale AFIS and Multi-biometric Face-Fingerprint Identification Systems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... , Feb. 2, 2016  Based on ... Frost & Sullivan recognizes US-based Intelligent Retinal Imaging ... & Sullivan Award for New Product Innovation. IRIS, ... North America , is poised ... rapidly growing diabetic retinopathy market. The IRIS technology ...
(Date:2/1/2016)... 2016  Today, the first day of American Heart ... develop a first of its kind workplace health solution ... In the first application of Watson ... ), and Welltok will create a new offering that ... analytics, delivered on Welltok,s health optimization platform. The effort ...
(Date:1/28/2016)... SAN JOSE, Calif., Jan. 28, 2016 Synaptics (NASDAQ: ... financial results for its second quarter ended December 31, 2015. ... the second quarter of fiscal 2016 increased 2 percent compared to ... the second quarter of fiscal 2016 was $35.0 million, or $0.93 ... Non-GAAP net income for the first quarter of fiscal 2016 ...
Breaking Biology News(10 mins):
(Date:2/3/2016)... DIEGO , Feb. 3, 2016   ... company with the first pluripotent stem cell-derived islet ... diabetes in clinical-stage development, today announced that ViaCyte ... Pharmaceutical Companies of Johnson & Johnson, have agreed ... group into ViaCyte.  The agreement provides ViaCyte with ...
(Date:2/3/2016)... , Feb. 3, 2016 Ascendis Pharma ... company that applies its innovative TransCon technology to address ... at an upcoming investor conference.Event:2016 Leerink Partners Global Healthcare ... Date:  , Wednesday, February 10, 2016 Time:  , ... www.ascendispharma.com . --> An audio webcast of ...
(Date:2/3/2016)... Colorado (PRWEB) , ... February 03, 2016 , ... ... hospitals, has established a new office dedicated to the North American healthcare market. ... turnkey solutions to healthcare facilities. The company will provide new pneumatic tube ...
(Date:2/3/2016)... ... February 03, 2016 , ... Resilinc ... summarizes and analyzes nearly 750 unique supply chain notifications and alerts generated by ... , Supply chain risk management practitioners subscribe to the EventWatch service to receive ...
Breaking Biology Technology: