Navigation Links
IUPUI stem cell research could expand clinical use of regenerative human cells
Date:3/19/2013

Research led by a biology professor in the School of Science at Indiana University-Purdue University Indianapolis (IUPUI) has uncovered a method to produce retinal cells from regenerative human stem cells without the use of animal products, proteins or other foreign substances, which historically have limited the application of stem cells to treat disease and other human developmental disorders.

The study of human induced pluripotent stem cells (hiPSCs) has been pursued vigorously since they were first discovered in 2007 due to their ability to be manipulated into specific cell types. Scientists believe these cells hold considerable potential for cell replacement, disease modeling and pharmacological testing. However, clinical applications have been hindered by the fact that, to date, the cells have required animal products and proteins to grow and differentiate.

A research team led by Jason S. Meyer, Ph.D., assistant professor of biology, successfully differentiated hiPSCs in a lab environmentcompletely through chemical methodsto form neural retinal cell types (including photoreceptors and retinal ganglion cells). Tests have shown the cells function and grow just as efficiently as those cells produced through traditional methods.

"Not only were we able to develop these (hiPSC) cells into retinal cells, but we were able to do so in a system devoid of any animal cells and proteins," Meyer said. "Since these kinds of stem cells can be generated from a patient's own cells, there will be nothing the body will recognize as foreign."

In addition, this research should allow scientists to better reproduce these cells because they know exactly what components were included to spur growth and minimize or eliminate any variations, Meyer said. Furthermore, the cells function in a very similar fashion to human embryonic stem cells, but without controversial or immune rejection issues because they are derived from individual patients.


'/>"/>
Contact: David Hosick
dhosick@iupiu.edu
317-274-4585
Indiana University-Purdue University Indianapolis School of Science
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Dartmouth researchers invent real time secondhand smoke sensor
2. St. Jude Childrens Research Hospital announces issuance of US patent for cancer therapy
3. Wireless, implanted sensor broadens range of brain research
4. UMass Amherst researchers reveal mechanism of novel biological electron transfer
5. DFG establishes 8 new research units
6. DDW: The latest and most thought-provoking research in GI
7. Researchers create map of shortcuts between all human genes
8. UEA research reveals catastrophic loss of Cambodias tropical flooded grasslands
9. Antarctic soil researcher awarded prestigious 2013 Tyler Environmental Prize
10. New research paper says we are still at risk of the plague
11. UF researcher describes new 5-million-year-old saber-toothed cat from Florida
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
IUPUI stem cell research could expand clinical use of regenerative human cells
(Date:8/27/2014)... is entering what is described by the Volunteer Wildfire ... The Eastern Cape provincial government warned residents in certain ... winds and veld fires. A high veld fire ... along the coast in the Great Kei and Mnquma ... and during thunderstorms. The thunderstorms bring lightning strikes ...
(Date:8/27/2014)... as giant, frightening beasts. But every creature is a ... slab containing fossils of 24 very young dinosaurs and ... hatchlings overseen by a caretaker, according to a new ... P. Hedrick and Peter Dodson led the work, collaborating ... where the specimen is held. Hedrick is a doctoral ...
(Date:8/27/2014)... exists as five strains, none of which have approved ... Sudan ebolavirus (SUDV). Although not the strain currently devastating ... recently as 2012. In a new study appearing in ... report a possible therapy that could someday help treat ... Jonathan Lai and colleagues explain that about 50-90 percent ...
Breaking Biology News(10 mins):Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 2Penn paleontologists describe a possible dinosaur nest and young 'babysitter' 3Potential therapy for the Sudan strain of Ebola could help contain some future outbreaks 2
... Washington, D.C.Recent climate modeling has shown that ... atmosphere would give the Earth a wetter climate ... Global Ecology scientists Long Cao and Ken Caldeira ... wetter when atmospheric carbon dioxide (CO2) concentrations are ...
... (March 24, 2011) Researchers with the Los Angeles ... of the multi-drug resistant pathogen, carbapenem-resistant Klebsiella pneumoniae (CRKP) ... compared to general acute care hospitals across the county. ... thought to be contained to East Coast facilities and ...
... and brings new dimensions into teaching and research. ... have in collaboration with the Finnish company Multitouch Ltd ... method is a combination of two technologies: web-based virtual ... is an entirely new way of performing microscopy: by ...
Cached Biology News:Cutting carbon dioxide helps prevent drying 2Drug-resistant pathogen found in large numbers in LA County 2Big size multitouch display turned into a microscope 2
(Date:8/28/2014)... Earlier this month, a report ... with the U.S. Air Force on the performance of ... that this type of fuel made from mustard seeds, ... important to America’s Eco friendly future. In fact, every ... to become independent of foreign oil over the next ...
(Date:8/28/2014)... Diego, CA (PRWEB) August 28, 2014 ... Pipette.com is offering a promotion for Eppendorf ... Pipette.com customers to purchase the highest quality tubes ... Tubes are ideal for customers doing chemical, medical, ... lab technicians who are not regularly able to ...
(Date:8/27/2014)... City, Utah (PRWEB) August 27, 2014 ... that will expand its current Salt Lake City manufacturing ... underway outside of Utah to ultimately create 1,000 new ... 20 years. , “Utah is home to hardworking ... whom can be credited with Varian’s success in the ...
(Date:8/27/2014)... 2014 Rhythm, a biopharmaceutical company developing peptide ... result in metabolic disorders, announced today that it has ... U.S. Securities and Exchange Commission (SEC) relating to the ... stock. The number of shares to be offered and ... been determined. Citigroup and Cowen and Company ...
Breaking Biology Technology:Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 2Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 3Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 4Can Small Farmers and a New Seed Based Biofuel “Green” the World? Major Universities and Even the U.S. Air Force Seem to Think So 5Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3Rhythm Files Registration Statement for Proposed Initial Public Offering 2
... Arena Pharmaceuticals, Inc.,(Nasdaq: ARNA ) today ... 30, 2008., Total revenues in the second ... million in the second quarter of 2007, and ... agreement with,Siegfried Ltd and $0.6 million in patent ...
... Aug. 5 /PRNewswire-FirstCall/ - Atrium Innovations Inc.,(TSX: ATB), ... and professionally endorsed products for the health and,nutrition ... Officer, Mr. Pierre Fitzgibbon, will present a company ... Growth Conference on,Tuesday, August 12, 2008 at 11 ...
... Ltd. to Support Partnership, Comprehensive service will ... implementation of cognitive testing in clinical trials, BETHESDA, ... United BioSource Corporation (UBC) and CogState Ltd. enter into ... in,clinical trials., -- UBC has made a direct ...
Cached Biology Technology:Arena Pharmaceuticals Announces Second Quarter 2008 Financial Results and Recent and Second Quarter Highlights 2Arena Pharmaceuticals Announces Second Quarter 2008 Financial Results and Recent and Second Quarter Highlights 3Arena Pharmaceuticals Announces Second Quarter 2008 Financial Results and Recent and Second Quarter Highlights 4Arena Pharmaceuticals Announces Second Quarter 2008 Financial Results and Recent and Second Quarter Highlights 5Arena Pharmaceuticals Announces Second Quarter 2008 Financial Results and Recent and Second Quarter Highlights 6Arena Pharmaceuticals Announces Second Quarter 2008 Financial Results and Recent and Second Quarter Highlights 7Arena Pharmaceuticals Announces Second Quarter 2008 Financial Results and Recent and Second Quarter Highlights 8Arena Pharmaceuticals Announces Second Quarter 2008 Financial Results and Recent and Second Quarter Highlights 9United BioSource Corporation and CogState Ltd. Form Strategic Partnership to Support Cognitive Assessment in Clinical Research 2United BioSource Corporation and CogState Ltd. Form Strategic Partnership to Support Cognitive Assessment in Clinical Research 3United BioSource Corporation and CogState Ltd. Form Strategic Partnership to Support Cognitive Assessment in Clinical Research 4