Navigation Links
ISU researchers find possible treatment for spinal muscular atrophy
Date:7/27/2009

AMES, Iowa - Spinal Muscular Atrophy is the second-leading cause of infant mortality in the world.

Ravindra Singh, associate professor in biomedical sciences at Iowa State University's College of Veterinary Medicine, would like to see Spinal Muscular Atrophy lose its high ranking and even slide off the list altogether.

Most Spinal Muscular Atrophy sufferers -- more than 95 percent -- have a mutated or deleted gene called Survival Motor Neuron 1 (SMN1) that doesn't correctly do its job of creating functional SMN proteins.

Singh's solution is to replace that poor-performing gene with another gene.

Humans need a certain level of SMN protein to ward off Spinal Muscular Atrophy.

When SMN1 fails to create functioning proteins, Spinal Muscular Atrophy is the result.

There is a gene already in humans that looks very much like SMN1, so much so that it's called SMN2. The SMN2 gene doesn't seem to serve any function that researchers can identify.

Singh has discovered a way of using SMN2 to produce the working SMN protein. When SMN2 makes enough SMN, it compensates for the mutated or malfunctioning SMN1 gene.

All proteins in human bodies are made by copying genes. This copy is called pre-mRNA.

Pre-mRNA then becomes mRNA by splicing out certain parts of the sequence that are non-coding, meaning they don't help the function of the gene.

These non-coding portions of the pre-mRNA are called intronic sequences, sometimes referred to as junk sequence because it is originally copied from junk DNA.

SMN2 normally doesn't produce normal protein because of the presence of a specific intronic sequence in the gene or DNA.

To make SMN2 behave as SMN1, Singh has introduced a small antisense oligonucleotide that blocks this specific intronic sequence.

When the intronic sequence is blocked, SMN2 produces normal proteins and acts, in effect, like SMN1.

"The significance of our
'/>"/>

Contact: Ravindra Singh
singhr@iastate.edu
515-294-8505
Iowa State University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers capture bacterial infection on film
2. Researchers design first model motor nerve system thats insulated and organized like the human body
3. Iowa State University researchers develop process for surgical genetic changes
4. UCLA researchers discover new molecular pathway for targeting cancer, disease
5. Munich researchers discover new target for tailored antibiotics
6. Baylor researchers unravel mystery of DNA conformation
7. Researchers achieve major breakthrough with water desalination system
8. Researchers gain insight into mechanism underlying Huntingtons
9. Alzheimers disease drug treats traumatic brain injury, report GUMC researchers
10. UTSA infectious disease researchers advancing vaccine against Valley fever
11. Canadian researchers set to study impact of nanomaterials on aquatic ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
ISU researchers find possible treatment for spinal muscular atrophy
(Date:5/11/2015)... -- Curemark LLC, a privately held drug research and ... III double blind, randomized, placebo-controlled clinical trial to examine ... children ages 3-8 with Autism. Previously, Curemark announced the ... clinical trial for CM-AT in children ages 3-8 with ... chymotrypsin. This new trial will help determine whether all ...
(Date:5/6/2015)... 6, 2015 LifeBEAM, a developer of bio-sensing ... announced today that they will expand their partnership in ... bio-sensing cycling helmet and the first joint project between ... colors in order to give cyclists more style choices ... LifeBEAM and Lazer announced their plan to release a ...
(Date:4/27/2015)... Fla. , Apr. 27, 2015 Profile ... access control and security systems is pleased to announce ... company as a consultant and member of its scientific ... is widely known as a thought leader in technology-enhanced ... Learning Technology Group, and has published studies and books ...
Breaking Biology News(10 mins):Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4
... Researchers at Georgetown University Medical Center have discovered ... on genes that can push stem cells embedded in a ... build blood vessels to link up to the body,s blood ... published in the July 16 online issue of PLoS ...
... Although sickle cell disease is a single-gene disorder, its ... July 14 by the Proceedings of the National ... and the Dana Farber Cancer Institute (DFCI), in collaboration ... five gene variants that could potentially be helpful in ...
... 15, 2008 A new book from the Soil Science Society of ... living world of soil. Soil! Get the Inside Scoop explores how ... the air we breathe, the water we drink, the houses we ... healthy plants and food production. Written for children age 9 to ...
Cached Biology News:Vitamin A pushes breast cancer to form blood vessel cells 2Vitamin A pushes breast cancer to form blood vessel cells 3Gaining ground on sickle cell disease 2Gaining ground on sickle cell disease 3
(Date:5/21/2015)... 21, 2015  Prima Biomed Ltd. (NASDAQ: PBMD ... to become a leader in the development of immunotherapeutic ... the final CVac data from the Phase II CAN-003 ... for a clinically meaningful improvement in Overall Survival ("OS") ... In the group of second remission patients ...
(Date:5/21/2015)... May 21, 2015  The EveryLife Foundation for ... (R-UT) and Amy Klobuchar (D-MN) today ... Cures & Treatments, or OPEN ACT. ... advocacy organizations, this bipartisan legislation promises to rapidly ... to rare disease patients by incentivizing drug makers ...
(Date:5/21/2015)... May 21, 2015 W. R. ... manufacturing facility in Worms, Germany has received good ... subsidiary of the International Pharmaceutical Excipient Council (IPEC) ... that produce its SYLOID® FP brand of pharmaceutical ... certification, following the Curtis Bay, Maryland (USA) and ...
(Date:5/21/2015)... , May 21, 2015  CytRx Corporation ... development company specializing in oncology, today announced positive ... trial with aldoxorubicin for the treatment of unresectable ... cancer.  The open-label, multisite trial is designed to ... in patients whose tumors have progressed following prior ...
Breaking Biology Technology:Correction Continues after Big Move - BrokerBank Securities, Inc. 2Advocates Cheer Senate Leaders for Introducing Bipartisan Bill to Increase Number of Rare Disease Treatments 2Grace European Facility Receives GMP Excipient Certification for SYLOID® FP Silica Gel 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 2CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 3CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 4CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 5CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 6CytRx Reports Positive Updated Phase 2 Aldoxorubicin Clinical Trial Results in Glioblastoma Multiforme (Brain Cancer) 7
... , , , ... Choose Shrimp Alkaline Phosphatase,for Easier Heat Inactivation , ... , , Simplify dephosphorylation of 5′ ends ... Shrimp Alkaline Phosphatase completely,and irreversibly by heating at 65 C for only 15 ...
... , , ... , Polymerase chain reaction (PCR) setup typically requires,thawing of ... individual reaction tubes. ,The various handling steps, , , ... , bear the risk of contaminating the amplification,reaction and , ...
... , , Product Literature Center Articles , , ... , , ... Patterns with Improved Tools for Target Amplification , , , ... FastStart Taq DNA Polymerase and the Novel FastStart High Fidelity PCR System , ...
Cached Biology Technology:Reduce Errors and Save Time When Setting Up PCRs 2Roche Diagnostics Corporation 2Roche Diagnostics Corporation 3Roche Diagnostics Corporation 4Roche Diagnostics Corporation 5
15(S)-HETE-d8 is used as an internal standard for the quantification of 15(S)-HETE by stable isotope dilution mass spectrometry....
5(S)-HETE-d8 is used as an internal standard for the quantification of 5(S)-HETE by stable isotope dilution mass spectrometry....
...
Full-length cDNA clone CS0DJ013YG01 of T cells (Jurkat cell line) of Homo sapiens (human). [Source:Uniprot/SPTREMBL;Acc:Q86SZ3] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: