Navigation Links
ISU researchers discover cause of immune system avoidance of certain pathogens
Date:8/17/2010

AMES - A special set of sugars found on some disease-causing pathogens helps those pathogens fight the body's natural defenses as well as vaccines, say two Iowa State University researchers.

This discovery may be a first step in understanding a disease family that includes tuberculosis for which there are currently no good vaccines or cures.

Nicola Pohl, professor of chemistry, and Christine Petersen, assistant professor of veterinary pathology, discovered that a natural coating of sugar interacts with the body's defense cells to dampen its own immune response.

The findings are published in the current online issue of the Journal of the American Chemical Society.

Pohl and Petersen began studying persistent pathogens such as tuberculosis and the parasite Leishmania five years ago when they noticed that some types of the parasite can make people sick, while others do not.

"One of the things I was curious about was that pathogenic strains of Leishmania have a different sugar coating on them than nonpathogenic strains," Pohl said.

"We asked the question 'Is it possible that just the sugar coating is enough to make something pathogenic or nonpathogenic?'" she said.

Leishmania-associated diseases are not usually found in the United States, but have been observed in soldiers returning from the Middle East. The diseases can cause unsightly sores, and can last a period of months, according to Pohl.

The diseases are often fatal to dogs in the United States.

"The problem is, in places like Bangladesh, where people are in a nutritionally compromised state, peoples' immune systems aren't strong enough, and the disease can be fatal," said Pohl.

Normally, when a disease-causing agent enters the body, cells called macrophages engulf and start to destroy the agent.

Leishmania-type diseases are resistant to this process.

To test the theory on the resistance effect
'/>"/>

Contact: Nicola Pohl
npohl@iastate.edu
515-294-2339
Iowa State University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers develop MRSA-killing paint
2. Researchers discover genetic link between immune system, Parkinsons disease
3. Ben-Gurion U. researchers receive US-AID MERC grant for water project with the Palestinian authority
4. Illinois researchers use pyrosequencing to study canine intestinal bacteria
5. Researchers find that one type of stem cell creates a niche for another type in bone marrow
6. VIB and UGent researchers identify key mechanisms of cell division in plants
7. Rutgers researchers assess severity of prostate cancers using magnetic resonance imaging
8. Carnegie Mellon researchers turn up brightness on fluorescent probes
9. Researchers demonstrate highly directional terahertz laser rays
10. Hebrew University researchers identify gene related to chronic pain
11. UC Riverside researchers measure diesel emissions on the freeway
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2014)... biologists, led by Clemson University associate professor Andrew S. ... will pave the way for novel anti-fouling paint for ... and industrial applications. , The team,s findings, published in ... larval stage of barnacles that attaches to a wide ... material that acts as an underwater heavy-duty adhesive. , ...
(Date:7/30/2014)... , July 30, 2014 NexID ... and liveness detection solutions for the biometric authentication ... industry consortium revolutionizing online authentication with standards for ... Cornett , "The decision to join FIDO Alliance ... authentication pervasive in use. We believe the FIDO ...
(Date:7/30/2014)... out how to create colors, nature had already perfected ... many different hues, for example. Now scientists are tapping ... way to make colored plastics. Their paper on using ... rather than dyes, to produce color appears in ... Asger Mortensen, Anders Kristensen and colleagues point out that ...
Breaking Biology News(10 mins):Study: Marine pest provides advances in maritime anti-fouling and biomedicine 2NexID Biometrics Joins the FIDO Alliance 2
... Va. A five-year-old Virginia Tech outreach program, ... doing research and providing results that scientists can ... Partnership Award from the National Center for Research ... of Health. The Fralin Life Science Institute,s Partnership ...
... If you would like to receive Science Picks via e-mail, ... to receive it, please e-mail kcapelli@usgs.gov . October ... Sumatra Earthquakes, DOI Prepared to Address Climate Change, Water is ... of Seismic Proportions, Forget the Garlic Necklace! Learn More about ...
... attention to National Child Health Day (today), the Preventive Cardiovascular ... consumer survey and launched a campaign to educate families about ... The national survey revealed that more than three in ... heart disease do not begin until adulthood. ...
Cached Biology News:NIH funds new phase of high school-university research partnership 2NIH funds new phase of high school-university research partnership 3USGS Science Picks 2USGS Science Picks 3USGS Science Picks 4USGS Science Picks 5USGS Science Picks 6USGS Science Picks 7USGS Science Picks 8USGS Science Picks 9Americans concerned about heart health, but not proactive enough to prevent it 2
(Date:7/30/2014)... 2014 While administrative claims and ... research for a relatively long period of time, ... the use of these ‘big data’ for comparisons ... combining today’s powerful computer technology with the plethora ... data’ holds significant promise for identifying optimal interventions ...
(Date:7/30/2014)... , July 30, 2014   Wyle ... the Fully Integrated Lifecycle Mission Support Services (FILMSS) ... Administration (NASA). Under the terms of the contract, ... Center at Moffett Field, Calif. In particular, Wyle ... bioscience flight development projects on the International Space ...
(Date:7/30/2014)... July 30, 2014 BCC Research ( ... Markets for Enzymes in Industrial Applications , the global ... nearly $7.1 billion by 2018, registering a five-year compound ... estimated to be recorded in the detergent enzyme segment ... , Enzyme technology has influenced almost every sector of ...
(Date:7/30/2014)... , July 30, 2014  Orexigen Therapeutics, Inc. ... received the Day 180 List of Outstanding Issues (LOI) ... for Human Use (CHMP) for the NB32 Marketing Authorization ... SR) is an investigational drug candidate being evaluated for ... earlier Day 120 time point were adequately addressed by ...
Breaking Biology Technology:Leveraging ‘Big Data’ - Methodological Considerations in Health Services Research, New Webinar Hosted by Xtalks 2Wyle Wins NASA's Fully Integrated Lifecycle Mission Support Services Contract 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 2Global Market for Industrial Enzymes to Reach Nearly $7.1 Billion by 2018; Detergent Enzyme Market to Record Maximum Growth 3Orexigen Receives CHMP Day 180 List of Outstanding Issues 2Orexigen Receives CHMP Day 180 List of Outstanding Issues 3
... 2011 Arecor, the leading company ... and vaccines, is pleased to announce the appointment ... Howell will be responsible for the operations of ... Arecor,s upward growth curve ensuring the company continues ...
... Nov. 10, 2011 Avaxia Biologics, Inc. , ... act locally within the gastrointestinal tract, announced today that ... of a Series A angel-led financing. Cherrystone Angels of ... Boston Harbor Angels and other undisclosed individuals. Mr. Robert ...
... Discovery Laboratories, Inc. (Nasdaq: DSCO ), ... respiratory critical care, today reports financial results for the third ... of the SURFAXIN® and AFECTAIR™ programs.  The Company will host ... call details are below. Selected third quarter highlights ...
Cached Biology Technology:Arecor Appoints Dr. Sarah Howell as Chief Operating Officer 2Avaxia Biologics, Inc. Raises $2.2 Million in First Closing of Series A Financing to Advance Oral Antibodies for Inflammatory Bowel Disease 2Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 2Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 3Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 4Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 5Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 6Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 7Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 8Discovery Labs Reports Third Quarter Financial Results and Progress on Lead Programs 9
...
BD BioCoat Poly-D-Lysine 60 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of poly-D-lysine....
... 4000 incorporates the critical design features demanded ... biomarker research. The Series 4000 delivers improved ... biomarker discoveries to biomarker assays all on ... designed to fit into the research plans ...
Gelatin 100 mm Culture Dishes...
Biology Products: