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ISU researchers develop hybrid protein tools for gene cutting and editing
Date:8/30/2010

the DNA to make the cut.

Another study had similar results.

The concept has also been proven by Bogdanove and Dan Voytas, collaborator in genetics, development and cell biology at Iowa State, and director of the Center for Genome Engineering at the University of Minnesota, Twin Cities.

The TAL effector-nuclease approach improves on tools currently available for genome modification. It should be faster and less expensive to make TAL effector nucleases, and easier to design them to recognize specific DAN sequences, according to Yang.

Yang's findings recently appeared in the online version of the journal Nucleic Acids Research. Voytas' and Bogdanove's study also appeared recently in the journal Genetics.

Voytas and Bogdanove were also able to show that the TAL effector part of the hybrid protein can be customized to target new DNA sequences.


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Contact: Bing Yang
byang@iastate.edu
515-294-2968
Iowa State University
Source:Eurekalert  

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