Navigation Links
ISU researcher identifies key function in protein, cell transcription
Date:5/1/2009

AMES, Iowa -- When cells decide to make proteins, key building blocks of all organisms, they need to know where to start reading the instructions for assembling them.

An Iowa State University researcher has figured out a mechanism involved in marking where these instructions are located in a cell's DNA.

In the current edition of The Journal of Biological Chemistry, Michael Shogren-Knaak, assistant professor in biochemistry, biophysics and molecular biology, along with Shanshan Li, a graduate student in his lab, show how a protein, Gcn5, is involved in this process.

When a portion of the Gcn5 protein recognizes chemically modified proteins associated with DNA, called histones, this recognition facilitates further chemical modification of the histones.

This allows the information contained in that DNA, or genes, to be read more efficiently.

"This is very important in normal cell development from single cell organisms to us (humans)," said Shogren-Knaak.

Understanding how DNA is read should shed light on diseases where DNA is often inappropriately read.

"This is very likely to be significant for diseases like cancer," said Shogren-Knaak.

"Cancer is distinguished by containing a lots of genes that should be turned off but aren't, and by proteins that should be made but aren't," he said. "That leads to cells that grow in an uncontrolled and undesirable manner."


'/>"/>

Contact: Michael Shogren-Knaak
knaak@iastate.edu
515-294-9015
Iowa State University
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Researchers discover new strategies for antibiotic resistance
9. Researchers find new taste in fruit flies: carbonated water
10. Binghamton University researchers investigate evolving malaria resistance
11. Antioxidant to retard wrinkles discovered by Hebrew University researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... 2017 Research and Markets has announced the ... to their offering. ... eye tracking market to grow at a CAGR of 30.37% during ... Market 2017-2021, has been prepared based on an in-depth market analysis ... and its growth prospects over the coming years. The report also ...
(Date:4/5/2017)... April 5, 2017  The Allen Institute for Cell ... Explorer: a one-of-a-kind portal and dynamic digital window into ... data, the first application of deep learning to create ... cell lines and a growing suite of powerful tools. ... these and future publicly available resources created and shared ...
(Date:4/3/2017)... , April 3, 2017  Data ... precision engineering platform, detected a statistically significant ... product prior to treatment and objective response ... the potential to predict whether cancer patients ... to treatment, as well as to improve ...
Breaking Biology News(10 mins):
(Date:7/26/2017)... ... July 26, 2017 , ... NLP ... the years of diagnostic excellence by Mayo Clinic and the experience in developing ... will be distributed through the Microsoft Azure platform and will focus on assisting ...
(Date:7/26/2017)... , July 26, 2017  Nurse practitioners play a ... the findings of a Merck Manuals survey released ... medical conference, revealed that most (88 percent) believe they spend ... treatments and prescriptions. ... Merck Manuals survey of 210 nurse ...
(Date:7/25/2017)... ... July 25, 2017 , ... ... and improve efficiency of livestock farming while reducing the use of antibiotics and ... intellectual property from Cornell University. , These new proprietary technologies expand the ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... US and Canada who have proven their superior service quality as rated by ... Staffing as an industry leader based on service quality ratings from their placed ...
Breaking Biology Technology: