Navigation Links
ISU researcher identifies key function in protein, cell transcription
Date:5/1/2009

AMES, Iowa -- When cells decide to make proteins, key building blocks of all organisms, they need to know where to start reading the instructions for assembling them.

An Iowa State University researcher has figured out a mechanism involved in marking where these instructions are located in a cell's DNA.

In the current edition of The Journal of Biological Chemistry, Michael Shogren-Knaak, assistant professor in biochemistry, biophysics and molecular biology, along with Shanshan Li, a graduate student in his lab, show how a protein, Gcn5, is involved in this process.

When a portion of the Gcn5 protein recognizes chemically modified proteins associated with DNA, called histones, this recognition facilitates further chemical modification of the histones.

This allows the information contained in that DNA, or genes, to be read more efficiently.

"This is very important in normal cell development from single cell organisms to us (humans)," said Shogren-Knaak.

Understanding how DNA is read should shed light on diseases where DNA is often inappropriately read.

"This is very likely to be significant for diseases like cancer," said Shogren-Knaak.

"Cancer is distinguished by containing a lots of genes that should be turned off but aren't, and by proteins that should be made but aren't," he said. "That leads to cells that grow in an uncontrolled and undesirable manner."


'/>"/>

Contact: Michael Shogren-Knaak
knaak@iastate.edu
515-294-9015
Iowa State University
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Researchers discover new strategies for antibiotic resistance
9. Researchers find new taste in fruit flies: carbonated water
10. Binghamton University researchers investigate evolving malaria resistance
11. Antioxidant to retard wrinkles discovered by Hebrew University researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/6/2017)... -- Delta ID Inc., a leader in consumer-grade iris scanning ... CES® 2017. Delta ID has collaborated with Gentex Corporation ... of iris scanning as a secure, reliable and convenient ... car, and as a way to elevate the security ... ID and Gentex will demonstrate (booth #7326 LVCC) a ...
(Date:1/3/2017)... LAS VEGAS , Jan. 3, 2017 ... announced the introduction of Onitor Track, an innovative biometric ... and men, showcasing this month at the 2017 Consumer ... . In the U.S., the World ... affect more than two-thirds of adults who are overweight ...
(Date:12/20/2016)... , Dec. 20, 2016 The ... sharing, rental and leasing is stoking significant interest ... radio frequency technology, Bluetooth low energy (BLE), biometrics ... as the next wave of wireless technologies in ... access system to advanced access systems opens the ...
Breaking Biology News(10 mins):
(Date:1/12/2017)... ... January 12, 2017 , ... Each year, Crain’s Detroit Business News ranks the ... evaluates the patent estate of a company, its impact and significance, and the likelihood ... the way in technologies that transform energy sources such as low dose X-ray and ...
(Date:1/12/2017)... ... January 12, 2017 , ... After ... Lisa Rosendahl’s doctors gave her only a few months to live. Now a ... that has stabilized Rosendahl’s disease and increased both the quantity and quality of ...
(Date:1/12/2017)... and Pune, India , January 12, 2017 ... Toxicity Testing Market by Type and End Users - Global Opportunity Analysis and Industry ... million by 2022 from $2,921 million in 2015, growing at a CAGR of 15.07% ... ... Allied Market Research Logo ...
(Date:1/11/2017)... Colo. (PRWEB) , ... January 11, 2017 , ... ... the journal Clinical Cancer Research show early promise of the investigational anti-cancer agent ... despite a median 5 previous treatment regimens. Twenty-seven percent of these heavily pretreated ...
Breaking Biology Technology: