Navigation Links
ISU researcher identifies key function in protein, cell transcription
Date:5/1/2009

AMES, Iowa -- When cells decide to make proteins, key building blocks of all organisms, they need to know where to start reading the instructions for assembling them.

An Iowa State University researcher has figured out a mechanism involved in marking where these instructions are located in a cell's DNA.

In the current edition of The Journal of Biological Chemistry, Michael Shogren-Knaak, assistant professor in biochemistry, biophysics and molecular biology, along with Shanshan Li, a graduate student in his lab, show how a protein, Gcn5, is involved in this process.

When a portion of the Gcn5 protein recognizes chemically modified proteins associated with DNA, called histones, this recognition facilitates further chemical modification of the histones.

This allows the information contained in that DNA, or genes, to be read more efficiently.

"This is very important in normal cell development from single cell organisms to us (humans)," said Shogren-Knaak.

Understanding how DNA is read should shed light on diseases where DNA is often inappropriately read.

"This is very likely to be significant for diseases like cancer," said Shogren-Knaak.

"Cancer is distinguished by containing a lots of genes that should be turned off but aren't, and by proteins that should be made but aren't," he said. "That leads to cells that grow in an uncontrolled and undesirable manner."


'/>"/>

Contact: Michael Shogren-Knaak
knaak@iastate.edu
515-294-9015
Iowa State University
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers identify proteins involved in new neurodegenerative syndrome
2. Texas researchers and educators head for Antarctica
3. MGH researchers describe new way to identify, evolve novel enzymes
4. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
5. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
6. U of MN researchers discover noninvasive diagnostic tool for brain diseases
7. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
8. Researchers discover new strategies for antibiotic resistance
9. Researchers find new taste in fruit flies: carbonated water
10. Binghamton University researchers investigate evolving malaria resistance
11. Antioxidant to retard wrinkles discovered by Hebrew University researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... NEW YORK , Jan. 24, 2017 /PRNewswire/ ... market study of the laboratory use of nuclear ... of 363 experienced end-users and profiled current practices, ... three years, as well as growth and opportunities. ... NMR, Instrument suppliers, NMR instruments, needs and innovation ...
(Date:1/21/2017)... , Jan 20, 2017 Research and ... Biometrics Market 2017-2021" report to their offering. ... The global voice recognition biometrics ... 2017-2021. The report covers the present scenario and ... 2017-2021. To calculate the market size, the report considers the revenue ...
(Date:1/18/2017)... ROCKVILLE, Md. , Jan. 18, 2017  In ... with respect to mergers and acquisitions (M&A), and Kalorama ... reasons for such acquisitions have been shifting. Generally, uncertainty ... and the U.S. has changed the acquisitions ... situation has resulted in companies buying partners outside of ...
Breaking Biology News(10 mins):
(Date:2/24/2017)... ... 24, 2017 , ... FireflySci, Inc is an explosive small business that continues ... goal of bringing their powerful cuvette and spectrophotometer calibration to the spectroscopy ... is going on as they add yet another mark on the global map. , ...
(Date:2/23/2017)... and NEW YORK , Feb. ... Lumeon , a leading digital health company, and ... provider of telemedicine and remote patient monitoring, announce ... telemedicine reimbursements.  DN Telehealth maximizes ... in real-time, extending consultations beyond a physical clinical ...
(Date:2/23/2017)... , Feb. 23, 2017  MIODx announced today ... two key immunotherapy technologies from the University of ... a method to monitor a patient for response ... and CTLA-4.  The second license extends the technology ... is likely to have an immune-related adverse event ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... ... (FDA) de novo clearance to begin marketing the SPEAC® System, the Brain Sentinel® ... adults at home or in healthcare facilities during periods of rest. A lightweight, ...
Breaking Biology Technology: