Navigation Links
ISU plant pathologist updates science community on groundbreaking research
Date:10/11/2011

AMES, Iowa In the two years since Iowa State University's Adam Bogdanove, along with student Matthew Moscou, published their groundbreaking gene research in the cover story of the journal Science, researchers around the world have built on those findings to explore further breakthroughs.

Science has published another article by Bogdanove in the Sept. 30 issue that updates the scientific community on where the research has been since 2009 and where it is heading.

"In the past two years, an extraordinary number of things have happened in this field," said Bogdanove, a professor of plant pathology. "This is really pretty revolutionary."

Bogdanove's research published in 2009 uncovered how so-called TAL (Transcription Activator-like) effector proteins bind to different DNA locations, and how particular amino acids in each protein determine those locations -- called binding sites -- in a very straightforward way.

Knowing this, scientists are using the proteins to target and manipulate specific genes, something that was much more difficult to accomplish prior to this research.

That could lead to breakthroughs in understanding gene function and improving traits in livestock and plants, and even treating human genetic disorders, according to Bogdanove.

Bogdanove says in the two years since his and Moscou's work was published, nearly two dozen research papers have been published using this discovery.

"We are so excited about the potential of these proteins. Just in the past six months they have been used successfully in model organisms such as yeast, zebrafish, and C. elegans (a type of worm used to study development), and even in human stem cells. There is some really innovative stuff going on," he said.

Model organisms are used to understand particular biological functions.

Bogdanove collaborated on this Science article with Dan Voytas, a former member of the Iowa State University faculty and now director of the Center for Genome Engineering at the University of Minnesota.

Bogdanove cautions in the article that the power of the technologies based on TAL effectors raises legal, sociological and ethical questions about how their use should be regulated, but says that it may be just a matter of a few years before these proteins see real application in areas such as crop improvement and human medicine.


'/>"/>

Contact: Adam Bogdanove
ajbog@iastate.edu
515-294-3421
Iowa State University
Source:Eurekalert  

Related biology news :

1. Danforth Plant Science Center awarded major bioenergy grant from US Department of Energy
2. Pragues 88 nature reserves threatened by invasive plant species
3. Seed time-capsule will aid study of plant evolution amid environmental change
4. Breakthrough: A robot brain implanted in a rodent
5. Productivity of land plants may be greater than previously thought
6. New approach challenges old ideas about plant species and biomass
7. Amateur botanists discover a genuflecting plant in Brazil
8. ASPB convenes leaders to chart future of plant science research
9. Scientists solve long-standing plant biochemistry mystery
10. Restoring forests and planting trees on farms can greatly improve food security
11. Small bowel transplant, Crohns experts from around the world hosted by Georgetown
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
ISU plant pathologist updates science community on groundbreaking research
(Date:6/14/2017)... , June 15, 2017  IBM (NYSE: IBM ) ... international tech event dedicated to developing collaboration between startups and ... on June 15-17. During the event, nine startups will showcase ... value in various industries. France ... the international market, with a 30 percent increase in the ...
(Date:5/6/2017)... 2017 RAM Group , Singaporean ... breakthrough in biometric authentication based on a ... to perform biometric authentication. These new sensors are based ... by Ram Group and its partners. This sensor will ... chains and security. Ram Group is a next ...
(Date:4/17/2017)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... its 2016 Annual Report on Form 10-K on Thursday April 13, ... ... the Investor Relations section of the Company,s website at http://www.nxt-id.com ... http://www.sec.gov . 2016 Year Highlights: ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... September 22, 2017 , ... ... host a booth at premier packaging event PACK EXPO International in Las Vegas ... Machinery Manufacturers Institute (PMMI). , At this year’s PACK EXPO at the Last ...
(Date:9/21/2017)... ... 21, 2017 , ... Dr. Greg Leyer, Chief Scientific Officer of UAS Labs, ... presentation is at 12:10pm in the Probiotics Resource Center, Mandalay Bay Expo Hall. ... discuss how probiotics have shown impressive data in areas outside the gut including heart ...
(Date:9/21/2017)... ... September 21, 2017 , ... When a downtown Greenville portion ... swift and efficient thanks to the continuing efforts of members of the Reedy ... than 50 stakeholders, including officials from area counties and cities, Renewable Water Resources ...
(Date:9/20/2017)... ... 20, 2017 , ... Diversity focused business accelerator, The Refinery , announced ... to uncover the top technology-driven, women-led startups in Boston, MA, New Haven/Hamden, CT, and ... entrepreneurial events going on that week – in Boston, it will be part of ...
Breaking Biology Technology: