Navigation Links
ISG15: A novel therapeutic target to slow breast cancer cell motility
Date:1/11/2012

sions in breast cancer cells. Targeted knockdown of both ISG15 and UbcH8 resulted in reconstitution of the cytoskeletal architecture. Dr. Desai said "Disruption of cellular architecture is a hallmark of cancer. The ISG15 pathway is also elevated in a variety of tumors. Our results therefore reveal that the ISG15 pathway which is aberrantly elevated in tumors could disrupt cell architecture and contribute to breast cancer cell motility". "Because the cellular architecture is conserved and the ISG15 pathway is constitutively activated in tumor cells of different lineages, our observations in breast cancer must hold true for many other tumors".

If ISG15 confers motility to tumor cells in vivo, as suggested in this manuscript, then Dr. Desai concludes that "strategies to decrease ISGylation could provide a therapeutic advantage for patients diagnosed with metastatic tumors overexpressing the ISG15 pathway".

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said that "these intriguing studies by Desai and colleagues suggests that modulation of the ISG15 pathway may provide future therapeutic targets for breast cancer and other metastatic tumors".


'/>"/>
Contact: Dr. Shyamal D. Desai
sdesai@lsuhsc.edu
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover novel anti-viral immune pathway in the mosquito
2. Chinese herbal medicine may provide novel treatment for alcohol abuse
3. Autism may be linked to abnormal immune system characteristics and novel protein fragment
4. Novel device removes heavy metals from water
5. Barracuda babies: Novel study sheds light on early life of prolific predator
6. Scientist-novelist back with second book at cell biology meeting
7. University Hospitals Seidman Cancer Center tests novel drug that makes brain tumors glow hot pink
8. New study identifies novel role for PEA-15 protein in cancer growth
9. Novel monoclonal antibody offers potential treatment for tumors resistant to VEGF therapy
10. Benefit of novel drug in breast cancer seen in blood within weeks
11. Novel technique switches triple-negative breast cancer cells to hormone-receptor positive cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... of fairness did not evolve for the sake of ... benefits of continued cooperation, so say Frans de Waal, ... article about inequity aversion (IA), which is defined as ... published in Science . , Their conclusion ... studies to address their hypothesis that it is the ...
(Date:9/19/2014)... Sept. 19, 2014 Nxt-ID, Inc. (Nasdaq: NXTD ... focused on the growing m-commerce market, updates the "Wocket in Your ... the lightweight and light middleweight weight classes, Vinny Pazienza ... announced that Game of Thrones actor Ciaran Hinds ... Children star Katey Sagal have been cast in ...
(Date:9/18/2014)... - Washington State University researchers have developed a unique ... power waste cleanup in rural areas. , The ... an inexpensive and quick way to clean up waste ... while reducing pollution. , Professor Haluk Beyenal and ... Engineering and Architecture discuss the system in the online ...
Breaking Biology News(10 mins):Evolution of responses to (un)fairness 2Evolution of responses to (un)fairness 3NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3Researchers develop unique waste cleanup for rural areas 2
... MADISON, Wis. Certain lichens can break down the ... neurological disease fatal to wild deer and elk and spreading ... Survey research published today in the journal PLoS ONE ... by unusual, infectious proteins called prions. One of the best-known ...
... in an advance online publication in Nature Genetics ... which, combined with other approaches, may explain 40 to 50 ... a few years, proposes the study,s lead investigator. This approach, ... will potentially allow clinicians to "lift the hood on what ...
... HILL, MA (5/18/2011) Carbon found within ancient rocks has ... emergence of biological life on the planet billions of years ... from northern Canada has revealed the carbon-based minerals may be ... researchers report in the latest edition of the journal ...
Cached Biology News:Lichens may aid in combating deadly chronic wasting disease in wildlife 2New technique promises to 'lift the hood’ on autism 2New technique promises to 'lift the hood’ on autism 3New technique promises to 'lift the hood’ on autism 4Young graphite in old rocks challenges the earliest signs of life 2
(Date:9/22/2014)... , Sept. 22, 2014 Research and ... "Global and Chinese Microcrystalline Cellulose Industry Report 2014" ... and Chinese Microcrystalline Cellulose Industry Report 2014 is a ... the global microcrystalline cellulose industry with a focus on ... basic overview of the industry including definitions, classifications, applications ...
(Date:9/22/2014)... TORONTO , Sept. 22, 2014 ... (OTCBB:GNBT) today announced that it has entered into ... to which UHN,s Centre for Molecular Design and ... refinement project.  The goal of the project is ... the Company,s proprietary buccal insulin spray product, thereby ...
(Date:9/22/2014)... Washington, D.C (PRWEB) September 22, 2014 ... the top privately held biotechnology companies of 2014. ... of companies before selecting this year’s winners. Those ... private biotechnology companies in the industry. , ... a new group of Fierce 15 companies," said Carroll. ...
(Date:9/22/2014)... The US markets on Friday, September 19, ... Jones Industrial Average finished at 17,279.74, up 0.08% and ... S&P 500 finished the session 0.05% lower at 2,010.40. ... finished on a positive note. The S&P 500 Health ... 0.10%, with the index gaining 6.95% in the previous ...
Breaking Biology Technology:Global and Chinese Microcrystalline Cellulose Industry Report 2014 2Generex Collaborates with University Health Network for Buccal Insulin Project 2Generex Collaborates with University Health Network for Buccal Insulin Project 3Generex Collaborates with University Health Network for Buccal Insulin Project 4FierceBiotech Announces Annual “Fierce 15” Winners of 2014 2Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 2Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 3Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 4Stock Updates on Biotech Industry - Array BioPharma, Enzon Pharma, Alkermes, Amarin, and Synergy Pharma 5
... , SANTA ANA, Calif. , July ... with Prodimed, a company specializing in women,s health, located in ... distributing Prodimed,s extensive line of embryo transfer catheters, oocyte retrieval ... , Prodimed has a long ...
... PALO ALTO, Calif., July 21, Varian, Inc. (NasdaqGS: VARI) plans to release ... after 1:00 p.m. Pacific Time (PT) on Wednesday, July 29, 2009. A ... those quarterly results is scheduled to follow at 2:00 p.m. PT that ... can be accessed from Varian, Inc.,s Web site at www.varianinc.com ...
... ... Quantros Accreditation and Compliance Excellence Solution , ... San Francisco, CA (PRWEB) July 21, 2009 -- Quantros, a ... healthcare industry , announced today the highly positive results East Jefferson General Hospital (EJGH) ...
Cached Biology Technology:Quantros ACE Helps East Jefferson General Hospital Achieve Best-in-Class Performance 2Quantros ACE Helps East Jefferson General Hospital Achieve Best-in-Class Performance 3
... and reliable automation for today's drug ... laboratories. Staccato Mini-Workstations offer the minimal ... liquid handling and material management tasks. ... Caliper's time proven CLARA™ assay development ...
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
... high experimental throughput, minimum input of ... 4 up to 16 culture vessels ... users with proven fermentation results when ... fungi or any other microbial application. ...
Experion HighSens chips are the microfluidic chips used to perform high-sensitivity RNA analysis (picogram levels) with the Experion automated electrophoresis system. Each chip has the capacity to ru...
Biology Products: