Navigation Links
ISG15: A novel therapeutic target to slow breast cancer cell motility
Date:1/11/2012

Interferon-stimulated gene 15 (ISG15), a ubiquitin like protein, is highly elevated in a variety of cancers including breast cancer. How the elevated ISG15 pathway contributes to tumorigenic phenotypes remains unclear and is the subject of a study published in the January 2012 issue of Experimental Biology and Medicine. Dr. Shyamal Desai and her co-investigators from the Louisiana State University School of Medicine in New Orleans, the University of Pennsylvania School of Medicine in Philadelphia, and the Robert Wood Johnson School of Medicine in New Jersey report that gene knock-down studies demonstrate that elevated ISG15 pathway results in disruption of the cytoskeletal architecture of breast cancer cells. ISG15 also inhibits degradation of cellular proteins involved in cell motility, invasion, and metastasis, promoting breast cancer cell migration.

Dr. Desai said "Using ISG15 and UbcH8 gene knocked-down approach, our recent published and unpublished results explicitly demonstrated that the ISG15 pathway inhibits the ubiquitin-mediated proteasome-dependent protein degradation in breast cancer cells. We were the first to recognize this antagonizing effect of ISG15 in cancer cells"; however, others are increasingly coming to the same conclusion in their observations that ISG15 conjugation stabilizes cellular proteins.

Dr. Arthur Haas said "Given the crucial role of the ubiquitin/26S proteasome pathway in normal cell homeostasis, one expects that ISG15-induced downregulation of the ubiquitin pathway must contribute to breast tumor cell viability. Concurrently, in this manuscript we demonstrate that ISG15 promotes breast cancer cell migration by inhibiting ubiquitin-mediated degradation of cellular proteins associated with cell motility, invasion and metastasis".

The authors report that the elevated ISG15 pathway results in disruption of the cytoskeletal architecture effecting actin polymerization and formation of focal adhe
'/>"/>

Contact: Dr. Shyamal D. Desai
sdesai@lsuhsc.edu
Society for Experimental Biology and Medicine
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. Researchers discover novel anti-viral immune pathway in the mosquito
2. Chinese herbal medicine may provide novel treatment for alcohol abuse
3. Autism may be linked to abnormal immune system characteristics and novel protein fragment
4. Novel device removes heavy metals from water
5. Barracuda babies: Novel study sheds light on early life of prolific predator
6. Scientist-novelist back with second book at cell biology meeting
7. University Hospitals Seidman Cancer Center tests novel drug that makes brain tumors glow hot pink
8. New study identifies novel role for PEA-15 protein in cancer growth
9. Novel monoclonal antibody offers potential treatment for tumors resistant to VEGF therapy
10. Benefit of novel drug in breast cancer seen in blood within weeks
11. Novel technique switches triple-negative breast cancer cells to hormone-receptor positive cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... May 22, 2013. Plastic additives known as phthalates ... everywhere: They turn up in flooring, plastic cups, ... the Centers for Disease Control and Preventionthe bodies ... have come under increasing scrutiny. A growing collection ... can leech from packaging and mix with food) ...
(Date:5/21/2013)... concept of "place" is increasingly being considered in ... have a new resource that can help them ... with the places in their lives. , ... new book co-edited by the Pacific Northwest Research ... human-centered approach to conservation. The book is published ...
(Date:5/21/2013)... USC have found that a class of pharmaceuticals can ... , The drugs, known as "TSPO ligands," are currently ... at the effects of TSPO ligand in young adult ... in aged mice when pathology was quite severe," said ... of Gerontology. "TSPO ligand reduced measures of pathology and ...
Breaking Biology News(10 mins):Study links chemicals widely found in plastics and processed food to elevated blood pressure in children and teens 2Drugs found to both prevent and treat Alzheimer's disease in mice 2
... antibody targeting a well known cell surface protein inhibited ... of the disease that did not respond to hormone ... UCLA Department of Urology and UCLA,s Jonsson Comprehensive Cancer ... N-cadherin, is up regulated or turned on in prostate ...
... This release is available in French . , Frank ... table would make people more aggressive, not less. After all, dont ... a game in hopes of pumping them up? And what about ... who dares take their meat away from them? Wouldnt that go ...
... Miss. A summit that,s both scientific conference and ... front lines of fighting obesity and related metabolic diseases ... sponsored by the University of Mississippi Medical Center and ... the Jackson Convention Complex. Obesity and related ...
Cached Biology News:UCLA researchers discover a potential target for therapy for patients with a deadly prostate cancer 2UCLA researchers discover a potential target for therapy for patients with a deadly prostate cancer 3Caveman behavioral traits might kick in at Thanksgiving table before eating 2Global Obesity Summit 2010 in Jackson addresses growing epidemic at ground zero 2Global Obesity Summit 2010 in Jackson addresses growing epidemic at ground zero 3Global Obesity Summit 2010 in Jackson addresses growing epidemic at ground zero 4Global Obesity Summit 2010 in Jackson addresses growing epidemic at ground zero 5
(Date:5/23/2013)... 23, 2013 Can economic incentives such ... motivate members of the public to increase their donations ... Johns Hopkins Carey Business School Assistant Professor Mario ... to a large body of recent research that supports ... 24, 2013, issue of Science that the World Health ...
(Date:5/23/2013)... May 23, 2013 The maker community ... types of inventions. They focus on learning practical skills ... community gravitate toward bringing their ideas to life via ... Movement, works on making projects using biology. Glowing Plant ... plants to make them glow with bioluminescence genes, and ...
(Date:5/23/2013)... EXTON, Pa. , May 23, 2013 /PRNewswire/ ... leading research and advisory firms for specialized biopharmaceutical ... gastroenterologists, hepatologists, and infectious disease specialists reported that ... warehousing patients (e.g., intentionally delaying treatment) in anticipation ... physicians than six months ago, when only 6 ...
(Date:5/23/2013)... 2013 Pressure BioSciences, Inc. (OTCQB: PBIO) ("PBI" ... host a teleconference to discuss its First Quarter 2013 ... teleconference information is provided below: Date: Thursday, ... (EDT) Dial-in: (800) 875-3456 (U.S.); (800) 648-0973 ... VS22823 For those unable to participate in ...
Breaking Biology Technology:Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 2Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 3Glowing Plant Releases Maker Kit, Enabling Anyone to Make a Glowing Plant at Home 2The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 2The Majority of Physicians that Treat Hepatitis C Virus (HCV) Have Begun "Warehousing" and Preparing Their HCV Patients for the Next Generation of HCV Treatments 3Pressure BioSciences, Inc. to Discuss First Quarter 2013 Financial Results and Provide Business Update 2
... Cardium Health, AirLogix, and Work/Life Innovations into Next Generation ... ... Company, BEDFORD, Mass., March 4 CaseNET, Inc., a provider ... of Centene Corporation (NYSE: CNC ), has selected,the CaseNET platform ...
... - Two new independent non-executive directors added to Board with ... ... Eutick, OAM appointed independent non-executive Chairman, BRISBANE, Australia, March ... the,appointment of John Lee and Robert Williamson to the Company,s ...
... SOUTH SAN FRANCISCO, Calif., March 4 Sunesis,Pharmaceuticals, ... developing novel anticancer therapeutics, will present data at ... by the Society of,Gynecologic Oncologists (SGO). This year,s ... Tampa Convention Center in Tampa, Fla., Interim ...
Cached Biology Technology:Nurtur(TM) Selects CaseNET to Enable Integrated Health and Life Management Capabilities 2Progen Expands Board of Directors 2Progen Expands Board of Directors 3Progen Expands Board of Directors 4Sunesis Pharmaceuticals to Present Interim Phase 2 Data for SNS-595 at the 39th Annual Meeting on Women's Cancer 2
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Rabbit anti-NFkB p105/p50 (Ser337) Class: Antibody Product Group: Signalling molecules and phospho-specific Antibody...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
Biology Products: