Navigation Links
IRSF awards over $650,000 for Translational Rett Syndrome research
Date:8/18/2011

Cincinnati, (OH) - The International Rett Syndrome Foundation (IRSF) announced today that it is awarding over $650,000 to support eight cutting-edge projects that aim to accelerate translational research to develop treatments for Rett syndrome. IRSF is the world's largest private source of funding for biomedical and clinical Rett syndrome research. Since 1998, IRSF has cumulatively funded over $24M in high quality, peer-reviewed basic and translational research grants that have significantly advanced Rett syndrome research towards finding a cure.

IRSF's Translational Research grant program includes two types of awards, which are the Help Accelerate Rett Therapeutics (HeART) and the Advanced Neurotherapeutic Grant of Excellence (ANGEL) awards. The funding from these grant awards will provide for early and late stage translational research to treat and reverse Rett syndrome (RTT).

The awarded projects from the first round of applications to the Translational Research grant program are geared towards drug discovery and development efforts as well as preparing for later stages of translational research. These funded projects fall into four main categories: (1) the development and testing of potential therapeutic compounds in animal models of Rett syndrome, (2) the development of outcome measures in humans that will be used in future clinical studies, (3) the development of a method for treatment, and (4) the development of a stem cell-based experimental system to be used in high-throughput drug screens. Together, they are in alignment with the objectives of IRSF's Translational Research grant program.

Stephen Bajardi, the executive director of IRSF, commented, "IRSF is pleased with the quality of these research projects and the significant steps they represent in moving Rett syndrome translational research forward."

New Translational Research Awards

John M. Bissonnette, MD, Oregon Health Sciences University
Serotonin and small molecule treatment of respiratory disorders in a mouse model of Rett syndrome

Qiang Chang, PhD, of University of Wisconsin-Madison
Establishing Neurons Differentiated from an Isogenic Pair of Rett Syndrome iPSC lines as Cell-Based Assay for Future Drug Screens

Jenny Downs, PhD, Curtin University
Daily physical activity in girls and women with Rett syndrome: An important outcome for clinical trials

Steven J. Gray, PhD, University of North Carolina at Chapel Hill
Development of Optimized AAV Vectors for Intra-CSF Administration in Rett mice

Walter Kaufmann, MD, Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Development of a Behavioral Outcome Measure for Rett Syndrome

Lucas Pozzo-Miller, PhD, University of Alabama-Birmingham
IGF-1 and TrkB Agonists as BDNF Mimetics for the Reversal of Dendritic Spine Pathologies and Network Hyperexcitability in the Hippocampus of MeCP2 Mutant Mice

Jay R. Shapiro, MD, Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
Treatment of Osteoporosis in Murine Rett Syndrome Models: A Comparison of Zoledronic Acid vs. Teriparatide on Osteoblast Function, Gene Expression and Bone Mass

Huda Y. Zoghbi, MD, Baylor College of Medicine
Therapeutic intervention to modulate the GABAergic and cholinergic systems in animal models of Rett syndrome


'/>"/>

Contact: Kathryn Kissam
Kkissam@rettsyndrome.org
804-519-6231
International Rett Syndrome Foundation
Source:Eurekalert

Related biology news :

1. NIH doles out $3M in new innovator awards to 2 UC San Diego faculty
2. NIH awards Clemson bioengineer $1.5 million to improve durability of tissue heart valves
3. Entertainment Software Association Foundation awards grant to FAS for immune attack
4. Audience Selected as Silver Winner in This Years Wall Street Journal Technology Innovation Awards and Winner of the Semiconductors Category
5. NIAID announces 25 new awards to develop radiation countermeasures
6. Human Microbiome Project awards funds for technology development, data analysis and ethical research
7. University success at national engineering awards
8. New Systems Biology Awards enable detailed study of microbes
9. Soil Science Society of America presents awards in Houston
10. ASU researchers receive NIH awards for studies of malaria and emergent disease
11. NIH funds 16 Science Education Partnership Awards
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2017)... 1, 2017  Aware, Inc. (NASDAQ: AWRE), a leading ... Richard P. Moberg has resigned, effective March 3, ... Financial Officer and Treasurer of Aware citing a desire ... a member of the Board of Directors of Aware. ... Executive Officer and co-President, General Counsel has been named ...
(Date:2/26/2017)... DALLAS , Feb. 25, 2017  Securus ... justice technology solutions for public safety, investigation, corrections ... of Recidivism and Reentry. "Too often, ... State prisons and county jails are trying to ... of inmates and friends and family members. While significant ...
(Date:2/16/2017)... , Feb. 16, 2017  Genos, a community ... that it has received Laboratory Accreditation from the ... is presented to laboratories that meet stringent requirements ... scientifically rigorous processes. "Genos is committed ... laboratory practices. We,re honored to be receiving CAP ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... ... March 28, 2017 , ... Ecovia Renewables, Inc. announced today ... grant from the National Science Foundation (NSF). Under the award , Ecovia ... of BioGel™ biopolymer materials for hygiene applications, particularly for use in the absorbent ...
(Date:3/28/2017)... and WASHINGTON , March ... service provider, GENEWIZ, will launch single-cell sequencing during the American ... Walter E. Washington Convention Center in Washington, ... researchers to perform differential gene expression of thousands of ... Experts on-hand at ...
(Date:3/28/2017)... SAN DIEGO , March 28, 2017  Viking ... focused on the development of novel therapies for metabolic ... officer, Brian Lian , Ph.D., will deliver a ... Annual NASH Investor Conference, being held April 3, ... Details for this presentation are as ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... release of LabKey’s newest software solution, LabKey Biologics . Built in collaboration ... and biotech organizations, LabKey Biologics provides drug research teams tools for biological entity ...
Breaking Biology Technology: