Navigation Links
IRB Barcelona researchers discover mechanism that regulates steroid hormone production in Drosophila
Date:3/7/2013

Looking at the transformation of a fly larva into a pupa may help researchers to understand the molecular mechanisms that trigger puberty. A study conducted on the fruit fly, Drosophila melanogaster, by scientists at the Institute for Research in Biomedicine (IRB Barcelona) led by ICREA research professor Marco Miln, identifies an miRNA as key to the relationship between hormones that control growth and sexual maturity. According to Miln, "accelerated growth or obesity can provoke premature puberty in humans, harming their development and this is a growing problem in Western societies. Today, physicians know very little about the molecular mechanisms behind premature puberty, and Drosophila is providing us with our first hints." Current Biology, the reference journal for basic biology and part of the Cell family of journals, has published the study today online.

The study, whose first author, Laura Boulan, is a french PhD student within the "la Caixa" International PhD Programme at IRB Barcelona, pulled apart the phases of development in the fly to reveal a delicate dialogue between growth and maturity, and found that it is regulated by the activity of an miRNA called bantam. The team discovered that insulin, a hormone involved in metabolism and growth, reduces the levels of bantam present in the cells. Reduced levels of bantam lead to an increase in steroid hormones levels. "This increase in steroid hormones causes growth to stop," says Miln. Though the relationship between metabolism, growth and puberty is already known, this study has identified for the first time the molecular mechanism that determines this relationship and has pinpointed bantam as a key mediator in the dialogue between the hormones involved.

These findings may be relevant to human health if elements homologous to those found in flies can be identified in people. "Premature sexual maturity slows down growth, preventing adults from developing properly," says Bo
'/>"/>

Contact: Snia Armengou
armengou@irbbarcelona.org
34-934-037-255
Institute for Research in Biomedicine (IRB Barcelona)
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
2. Researchers discover gateway in nucleus has a second important job no one noticed before
3. Researchers explain a key developmental mechanism for the first time in plants
4. Researchers find molecular switch turning on self-renewal of liver damage
5. UGA researchers shed light on ancient origin of life
6. Researchers discover workings of brains GPS system
7. Researchers propose new solution to ensure biofuel plants dont become noxious weeds
8. Temple researchers discover key to heart failure, new therapies on horizon
9. Researchers discover gene that causes obesity in mice
10. U of M researchers utilize genetically corrected stem cells to spark muscle regeneration
11. Researchers id queens, mysterious disease syndrome as key factors in bee colony deaths
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
IRB Barcelona researchers discover mechanism that regulates steroid hormone production in Drosophila
(Date:7/9/2014)... to species, selection for traits that are attractive to ... enhances opportunities to mate, the tail of male peacocks ... of California, Riverside have now found that sexual selection ... are linked. Describing the life histories of more than ... researchers found that species with placentas tend to have ...
(Date:7/9/2014)... puzzle behind nature,s ability to split the water ... development of artificial photosynthesis for clean, green and ... collaboration of scientists led by researchers with the ... SLAC National Accelerator Laboratory. , Working at ... most powerful x-ray laser, the researchers were able ...
(Date:7/9/2014)... children with traumatic injuries have identified an immune ... develop a hospital-acquired infection. The study, led by ... in June in the journal Shock , ... lead to the clinical implementation of quick-turnaround immune ... immune system damage following critical illness or injury ...
Breaking Biology News(10 mins):Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4Postcards from the photosynthetic edge 2Postcards from the photosynthetic edge 3Immune function predicts infection risk among child trauma patients 2Immune function predicts infection risk among child trauma patients 3
... released the final "Integrated Science Assessment for Oxides of ... the scientific literature on the potential adverse human health ... nitrogen dioxide or NO2. There are significant new ... review document released in 1993. Oxides of ...
... The outlook for air quality in Beijing during the Olympics ... do to improve it. That,s the conclusion drawn ... pollution data collected regularly for the last five years by ... a regional component to the pollutants that cause unhealthy air ...
... Jericho may help a joint Israeli-Palestinian-German research group combat ... the Kuvin Center for the Study of Infectious and ... is leading the Israeli team, the bones, which were ... seventy years ago, will be tested for tuberculosis, leprosy, ...
Cached Biology News:URI researcher: China can't fully fix air quality problem for Olympics 2Excavated Jericho bones may help Israeli-Palestinian-German team combat tuberculosis 2Excavated Jericho bones may help Israeli-Palestinian-German team combat tuberculosis 3
(Date:1/15/2014)... Two champions of science, technology, engineering, and mathematics ... competition for middle and high school students designed to ... The competition presents students with real-world problems experienced by ... and Sciences is a program administered by the ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched ... tinnitus. Patients listen to sound therapy that is tailor-made ... weeks to months, their tinnitus volume decreases. , AudioNotch has ... and Notched White Noise. Now, AudioNotch is pleased to announce ...
(Date:1/14/2014)... a leading provider of strategic communications services to corporations and organizations ... the United States and Europe ... is returning to the firm,s Washington, D.C. ... than two years of service as Associate Commissioner for the Office ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 iLab Solutions, the ... as the new Director of Product Strategy. In this role, ... as iLab sub-teams to guide in the development of iLab ... provides the maximum possible benefit to the scientific community by ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... SHANGHAI, China, July 9 /Xinhua-PRNewswire/ -- WuXi PharmaTech ... research,and development outsourcing company with operations in China ... Trabue D. Bryans, Vice President,and General Manager of ... subsidiaries of WuXi PharmaTech (Cayman) Inc., has been ...
... ULURU Inc. (Amex: ULU ),today announced that ... on a recent development, Wednesday, July 9, 2008 at ... call, please dial (800) 357-0498 for,international callers dial (850) ... the initiation of the teleconference. If you are unable ...
... Biotech and pharmaceutical,firms are developing a ... the,complicated drug discovery process, reports Genetic Engineering ... on a combination,of high-throughput screening methods, miniaturization ... article in the July issue,( http://www.genengnews.com/articles/chitem.aspx?aid=2527 ) ...
Cached Biology Technology:WuXi AppTec VP and GM Invited to Join the AAMI Standards Board 2WuXi AppTec VP and GM Invited to Join the AAMI Standards Board 3ULURU Inc. Announces Update on Recent Development 2GEN Reports on Novel Hit-to-Lead Drug Discovery Strategies 2
... gasket slides/kit Gasket slide kit (1x 22K ... or Gasket slide kit ... disposable gasket slides offered in either 11K or 22K ... The gaskets are carefully fabricated and batch tested ...
... This CLS number is ... to easily match Cornings product ... yet, please order under the ... contact customer service for assistance. ...
... description: self locking design in ice/water ... new product number, created to easily ... no availability yet, please order under ... contact customer service for assistance. ID ...
... Oligo Microarray Kit (V2), 2 x ... characterize expression of many thousands of ... during important biological processes. Each microarray ... known ORFs from the S288C strain ...
Biology Products: