Navigation Links
IOF-IFCC study summarizes fracture prediction strength of reference bone turnover markers
Date:3/4/2014

Nyon, Switzerland March 4, 2014

A new study by an International Osteoporosis Foundation (IOF) and International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) scientific working group summarizes the clinical performance of serum procollagen type I N propeptide (s-PINP) and serum C-terminal cross-linking telopeptide of type I collagen (s-CTX) in fracture risk prediction in untreated individuals in prospective cohort studies.

The current study follows a position paper published in 2011 by the IOF-IFCC Bone Marker Standards Working Group recommending the use of bone formation marker serum s-PINP and bone resorption marker serum s-CTX as reference markers to be used in future studies of fracture risk assessment.

In the study, ten potentially eligible publications were identified and six included in meta-analysis. The results showed a moderate but significant association between the bone turnover markers (BTMs) studied and the risk of future fractures not adjusted for bone mineral density (BMD). There was a significant association between s-PINP and the risk of fracture. The hazard ratio (HR) per standard deviation (SD) increase in s-PINP was 1.23 (95% CI: 1.09-1.39) for men and women combined unadjusted for bone mineral density. There was also a significant association between s-CTX and risk of fracture, HR per SD 1.18 (95% CI: 1.05-1.34) unadjusted for bone mineral density. For the outcome of hip fracture, the association between s-CTX and risk of fracture was slightly higher 1.23 (95% CI: 1.04-1.47).

"This is the first meta-analysis of BTMs which was made possible by standardising the expression of risk," said Working Group Co-Chair Professor Howard A. Morris, School of Pharmacy and Medical Sciences, University of South Australia. He added, "One strength of the study is that we were able to standardize the metric of predictive power. The metric used was the gradient of risk namely the increase in fracture hazard ratio between two individuals who differ by 1SD in BTM. This has the advantage of maximizing the use that can be made of publications that used differing indices of risk."

The fracture risk increased by approximately 20%, depending on the analyte and the outcome fracture that was studied. These gradients of risk are substantially lower than those reported for the use of femoral neck BMD in the prediction of fracture.

Professor John A. Kanis, IOF President and report author said, "More studies are required to better evaluate the independent role of BTMs in fracture risk prediction. The use of common reference BTMs in prospective cohort studies with the standardization of their measurements, as recommended by the IOF and the IFCC, will help address these important issues."


'/>"/>

Contact: Charanjit K. Jagait, Ph.D.
cjagait@iofbonehealth.org
41-229-940-102
International Osteoporosis Foundation
Source:Eurekalert

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Law that regulates shark fishery is too liberal: UBC study
3. New study will help protect vulnerable birds from impacts of climate change
4. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
5. BYU study: Using a gun in bear encounters doesnt make you safer
6. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
7. Pycnogenol (French maritime pine bark extract) shown to improve menopause symptoms in new study
8. Crystal structure of archael chromatin clarified in new study
9. EU-funded study underlines importance of Congo Basin for global climate and biodiversity
10. University of Houston study shows BP oil spill hurt marshes, but recovery possible
11. Study demonstrates cells can acquire new functions through transcriptional regulatory network
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... , March 28, 2017 The ... Hardware (Camera, Monitors, Servers, Storage Devices), Software (Video Analytics, ... Region - Global Forecast to 2022", published by MarketsandMarkets, ... 2016 and is projected to reach USD 75.64 Billion ... and 2022. The base year considered for the study ...
(Date:3/24/2017)... 24, 2017 The Controller General of Immigration from ... Abdulla Algeen have received the prestigious international IAIR Award for the ... Continue Reading ... ... Controller Abdulla Algeen (small picture on the right) have received the IAIR ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based ... to 2022", published by MarketsandMarkets, the market is expected to be worth USD ... 2022. Continue Reading ... ... ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... and LAGUNA HILLS, Calif. , Oct. ... Cancer Research, London (ICR) and University ... SKY92, SkylineDx,s prognostic tool to risk-stratify patients with multiple myeloma ... MUK nine . The University of Leeds ... partly funded by Myeloma UK, and ICR will perform the ...
(Date:10/10/2017)... ... 2017 , ... San Diego-based team building and cooking events company, Lajollacooks4u, has ... The bold new look is part of a transformation to increase awareness, appeal to ... period. , It will also expand its service offering from its signature gourmet cooking ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
(Date:10/9/2017)... DIEGO , Oct. 9, 2017  BioTech ... biological mechanism by which its ProCell stem cell ... critical limb ischemia.  The Company, demonstrated that treatment ... amount of limbs saved as compared to standard ... the molecule HGF resulted in reduction of therapeutic ...
Breaking Biology Technology: