Navigation Links
IADR/AADR publish study on obesity link to periodontitis
Date:10/31/2011

Alexandria, Va., USA - In a study titled "MicroRNA Modulation in Obesity and Periodontitis," lead author Romina Perri, University of North Carolina School of Dentistry, Oral Health Institute, conducted a pilot investigation to determine whether obesity or periodontal disease modified microRNA expression and whether there was any potential interaction between obesity and periodontitis that could involve microRNA modulation. This study is published in the Journal of Dental Research, the official publication of the International and American Associations for Dental Research (IADR/AADR).

In this investigation, total RNA was extracted from gingival biopsy samples collected from 20 patients in 4 groups (5 non-obese [BMI < 30kg/m2] participants with a healthy periodontium, 5 non-obese participants with periodontitis, 5 obese [BMI > 30kg/m2] participants with a healthy periodontium and 5 obese participants with periodontitis).

Two microRNA species (miR-18a,miR-30e) were up-regulated among obese individuals with a healthy periodontium. Two microRNA species (miR-30e,miR-106b) were up-regulated in non-obese subjects with periodontal disease and in the presence of periodontal disease and obesity, nine microRNAs were significantly up-regulated (miR-15a,miR-18a,miR-22,miR-30d,miR-30e,miR-103,miR-106b, miR-130a,miR-142-3p,miR-185 and miR-210). The authors conclude that the data are consistent with the concept that miRNA that are induced by chronic nutritional stress leading to obesity may also non-parsimoniously modulate inflammatory pathways within periodontal tissues and affect disease expression.

"The expression of specific microRNA species in obesity provides new insight into possible mechanisms of how risk factors might modify periodontal inflammation and may represent novel therapeutic targets," said JDR Editor-in-Chief William Giannobile.

A perspective article titled "Obesity, Inflammation and Oral Infections: are microRNAs the Missing Link?" was co-authored by Francesco D'Aiuto and Jean Suvan, University College London Eastman Dental Institute. In it, the authors suggest that these data could represent a mechanistic breakthrough in our understanding of the modulatory effects of obesity on periodontal tissue destruction, but caution reproducibility of these findings is needed in larger and well-characterized cohorts.


'/>"/>

Contact: Ingrid L. Thomas
ithomas@iadr.org
703-299-8084
International & American Associations for Dental Research
Source:Eurekalert

Related biology news :

1. IADR/AADR publish proceedings from Symposium on Tissue Injury and Pulp Regeneration
2. CHEO scientist advances biotherapeutics as published in Cancer Cell
3. Data publishing in Pensoft journals integrated with the Dryad Data Repository
4. Bulletin of the Atomic Scientists publishes Japanese translation of special Fukushima issue
5. Revolutionary changes to the Botanical Code published in 16 journals and 5 languages
6. Researchers publish study on neuronal RNA targeting
7. 2011 health conditions for travel to Mecca (Hajj) pilgrimage published
8. Open minded and open access: NeoBiota, a new publishing platform for invasion biologists
9. Pensoft Publishers launch a new mycological open-access journal
10. The first studies utilizing the Collaborative Cross mice are published in Genome Research
11. Mary Ann Liebert Inc. publishers reports upward trend in impact factors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... DAL ) customers now can use fingerprints instead of their boarding ... ... biometrics to board aircraft at Reagan Washington National Airport ... Delta,s biometric boarding pass experience that launched in May at the ... to allow eligible Delta SkyMiles Members who are enrolled in CLEAR to ...
(Date:6/14/2017)... June 15, 2017  IBM (NYSE: IBM ) is introducing ... event dedicated to developing collaboration between startups and global businesses, ... 15-17. During the event, nine startups will showcase the solutions ... various industries. France ... market, with a 30 percent increase in the number of ...
(Date:5/16/2017)... , May 16, 2017   Bridge Patient ... organizations, and MD EMR Systems , an ... partner for GE, have established a partnership to ... product and the GE Centricity™ products, including Centricity ... These new integrations will allow ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... PA (PRWEB) , ... October 10, 2017 , ... ... year’s recipients of 13 prestigious awards honoring scientists who have ... presented in a scheduled symposium during Pittcon 2018, the world’s leading conference and ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer ... first quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With ... with the challenge of how to continue to feed a growing nation. At the ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... line of medical marijuana products targeting the needs of consumers who are incorporating ... Kindred takes place in Phoenix, Arizona. , As operators of two successful Valley ...
(Date:10/7/2017)... ... October 06, 2017 , ... ... consulting for microscopy and surface analysis, Nanoscience Instruments is now expanding into ... a broad range of contract analysis services for advanced applications. Services will ...
Breaking Biology Technology: