Navigation Links
IADR/AADR publish study on obesity link to periodontitis
Date:10/31/2011

Alexandria, Va., USA - In a study titled "MicroRNA Modulation in Obesity and Periodontitis," lead author Romina Perri, University of North Carolina School of Dentistry, Oral Health Institute, conducted a pilot investigation to determine whether obesity or periodontal disease modified microRNA expression and whether there was any potential interaction between obesity and periodontitis that could involve microRNA modulation. This study is published in the Journal of Dental Research, the official publication of the International and American Associations for Dental Research (IADR/AADR).

In this investigation, total RNA was extracted from gingival biopsy samples collected from 20 patients in 4 groups (5 non-obese [BMI < 30kg/m2] participants with a healthy periodontium, 5 non-obese participants with periodontitis, 5 obese [BMI > 30kg/m2] participants with a healthy periodontium and 5 obese participants with periodontitis).

Two microRNA species (miR-18a,miR-30e) were up-regulated among obese individuals with a healthy periodontium. Two microRNA species (miR-30e,miR-106b) were up-regulated in non-obese subjects with periodontal disease and in the presence of periodontal disease and obesity, nine microRNAs were significantly up-regulated (miR-15a,miR-18a,miR-22,miR-30d,miR-30e,miR-103,miR-106b, miR-130a,miR-142-3p,miR-185 and miR-210). The authors conclude that the data are consistent with the concept that miRNA that are induced by chronic nutritional stress leading to obesity may also non-parsimoniously modulate inflammatory pathways within periodontal tissues and affect disease expression.

"The expression of specific microRNA species in obesity provides new insight into possible mechanisms of how risk factors might modify periodontal inflammation and may represent novel therapeutic targets," said JDR Editor-in-Chief William Giannobile.

A perspective article titled "Obesity, Inflammation and Oral Infections: are microRNA
'/>"/>

Contact: Ingrid L. Thomas
ithomas@iadr.org
703-299-8084
International & American Associations for Dental Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. IADR/AADR publish proceedings from Symposium on Tissue Injury and Pulp Regeneration
2. CHEO scientist advances biotherapeutics as published in Cancer Cell
3. Data publishing in Pensoft journals integrated with the Dryad Data Repository
4. Bulletin of the Atomic Scientists publishes Japanese translation of special Fukushima issue
5. Revolutionary changes to the Botanical Code published in 16 journals and 5 languages
6. Researchers publish study on neuronal RNA targeting
7. 2011 health conditions for travel to Mecca (Hajj) pilgrimage published
8. Open minded and open access: NeoBiota, a new publishing platform for invasion biologists
9. Pensoft Publishers launch a new mycological open-access journal
10. The first studies utilizing the Collaborative Cross mice are published in Genome Research
11. Mary Ann Liebert Inc. publishers reports upward trend in impact factors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... animal species for food or commercial food sale, has ... the decline of many species of primates and other ... than half of the species being consumed are birds, ... not only the meat made available for sale but ... by hunters and brought to villages for consumption, we ...
(Date:7/24/2014)... where electric cars ply silent freeways, solar panels blanket ... the earth, from howling winds and from the blazing ... it is technically and economically feasible to convert California,s ... energy. Published in Energy , the plan shows ... supply in California that could create tens of thousands ...
(Date:7/24/2014)... of researchers has developed a new nanoscale agent for ... for assessing the function and properties of the GI ... and treatment of gut diseases. , Illnesses ... and inflammatory bowel disease all occur in the intestine ... with diseases such as diabetes and Parkinson,s. , ...
Breaking Biology News(10 mins):Stanford study shows how to power California with wind, water and sun 2Stanford study shows how to power California with wind, water and sun 3Stanford study shows how to power California with wind, water and sun 4New imaging agent provides better picture of the gut 2
... The evolution of bird bills is related to climate according ... Brock University, Canada. By examining bill sizes of a ... found that birds with larger bills tend to be found ... smaller bills. The study led by Dr Matt Symonds ...
... , In what is believed to be the largest review of ... are more likely to clump faster than others, scientists at Johns ... which they say likely control that bodily function. "Our results ... produced from these genes, to develop tests that could help us ...
... The American Association for Cancer Research recognizes the first ... Act, which was signed into law by President Obama ... the Food and Drug Administration (FDA) to regulate the ... go into effect today include restrictions on youth access ...
Cached Biology News:Birds reduce their heating bills in cold climates 2Genetic septet in control of blood platelet clotting 2Genetic septet in control of blood platelet clotting 3AACR recognizes 1-year anniversary of tobacco law 2
(Date:7/24/2014)... MESA, Calif. , July 24, 2014  Now ... close to home. Rehealth Regenerative Therapies , located ... athletes and other physically active people a new health ... Regardless of age, countless patients suffer from ... sport activities, such as muscle tears, torn rotator cuff, ...
(Date:7/24/2014)... Quantum computers have yet to materialise. Yet, scientists ... making such computers faster. One such approach relies ... controlled by applying an electric field. A new ... coherently coupled quantum dots (TQDs) with electrical impulses ... for example, should TQDs be used as quantum ...
(Date:7/24/2014)... California (PRWEB) July 24, 2014 ... to advances in modeling lithium-ion battery storage capacity. ... benefit from a theoretical model created at ... University that predicts how carbon components will ... energy storage emphasizes the urgent need for higher-performance ...
(Date:7/24/2014)...  Neogen Corporation (Nasdaq: NEOG ) advised ... revenue from new rodenticide research are premature. In its ... July 22, 2014, Neogen,s CEO commented about several new ... "It was my intent Tuesday at our conference ... new type of rodenticide, but certainly not to give ...
Breaking Biology Technology:Stem Cells In Sports Injuries, Joints And Muscular Pain 2Stem Cells In Sports Injuries, Joints And Muscular Pain 3Getting More Life out of Lithium-ion Batteries 2Neogen comments on SenesTech 2
... 2010 Sequenom, Inc. (Nasdaq: SQNM ... describing results from the R&D "locked-assay" verification study ... for Molecular Medicine. (Logo:   ... entitled "Noninvasive Detection of Fetal Trisomy 21 by ...
... 2010 Dr. Russell L. Chapman, former President of ... the research and teaching of algal related science in ... Chairman of its Science Advisory Board including university outreach, ... one of the preeminent scholars in the field of ...
... Dec. 15, 2010 /PRNewswire-Asia-FirstCall/ -- China-Biotics, Inc. ("China-Biotics" or ... developer, manufacturer and distributor of probiotics products in China, ... Stockholders (the "Annual Meeting") will be held on Wednesday, ... Annual Meeting will be held at the Company,s executive ...
Cached Biology Technology:Sequenom Announces Publication Acceptance of Manuscript From Trisomy 21 R&D Verification Study 2Sequenom Announces Publication Acceptance of Manuscript From Trisomy 21 R&D Verification Study 3Dr. Russell L. Chapman Joins Aquatic Energy as the Chairman of its Science Advisory Board 2Dr. Russell L. Chapman Joins Aquatic Energy as the Chairman of its Science Advisory Board 3China-Biotics, Inc. to Hold 2010 Annual Meeting of Stockholders on March 9, 2011 2China-Biotics, Inc. to Hold 2010 Annual Meeting of Stockholders on March 9, 2011 3
... ESGRO Complete Derivation Kit is intended ... cells from delayed blastocysts in serum-free ... Clonal Grade ... Blastocyst Incubation Medium Trypsin Solution ...
streptavidin, Alexa Fluor® 750–allophycocyanin conjugate (Alexa Fluor® 750–allophycocyanin streptavidin) *1 mg/mL*...
Template and primers for preparation of internal control spots...
Biotin-OSu is used to label proteins, immunological agents, DNA and synthetic oligonucleotides. Biotin labeling is detected through enzymatically labeled avidin or streptavidin proteins that conforma...
Biology Products: