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Hypertension researcher encourages colleagues to expand their focus
Date:9/14/2013

elin B receptor plays a critical role in eliminating both acute and chronic salt loads by activating nitric oxide, a potent dilator of blood vessels, in the kidneys. In fact, the kidneys make more endothelin than any place in the body.

"We had no idea it was going to be this important in salt regulation," Pollock said. "The main point I want to make is that people studying hypertension, salt-sensitivity particularly, need to consider what is happening to the endothelin system when they are doing their research. There are only a handful of us who have been studying it with any real intensity."

Key questions include how the B receptor gets turned off. Interestingly, researchers already know that the angiotensin system shuts the receptor down when patients are on a low-salt diet. Do hypertensive patients on a low-salt diet also have their B receptors turned off? "It's a good question and another reason that targeting the renin-angiotensin-aldosterone system may not give you the whole answer," Pollock said.

The Lewis K. Dahl Memorial Lecture was established in 1988 by the Council for High Blood Pressure Research in honor of Dahl's pioneering work on the relations between salt, the kidney and hypertension, and for establishing the Dahl salt-sensitive rat, a major genetically based experimental model of hypertension. Pollock has been a fellow of the council since 2000.


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Contact: Toni Baker
tbaker@gru.edu
706-721-4421
Medical College of Georgia at Georgia Regents University
Source:Eurekalert

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